A5074406808- Cannabis and Cannabinoid Research
- Additive Manufacturing and 3D Printing Technologies
- Neurotransmitter Receptor Influence on Behavior
- Gas Sensing Nanomaterials and Sensors
- Boron and Carbon Nanomaterials Research
- Advancements in Battery Materials
- Neuroscience and Neuropharmacology Research
- Graphene research and applications
- Pain Mechanisms and Treatments
- Electrochemical sensors and biosensors
- Analytical Methods in Pharmaceuticals
- Conducting polymers and applications
- AI in cancer detection
- Supercapacitor Materials and Fabrication
- Hemoglobinopathies and Related Disorders
- MXene and MAX Phase Materials
- Quantum Dots Synthesis And Properties
- Perovskite Materials and Applications
- Advanced battery technologies research
- Electrocatalysts for Energy Conversion
- Iron Metabolism and Disorders
- Fuzzy Logic and Control Systems
- Nanoplatforms for cancer theranostics
- Sleep and Wakefulness Research
- Fullerene Chemistry and Applications
Armed Forces Hospital
2024-2025
University of Samarra
2020-2025
Virginia Commonwealth University
2015-2024
Imam Ja’afar Al-Sadiq University
2022-2024
Shobhit University
2024
University of Tabuk
2024
Imam Sadiq University
2023-2024
University of Liverpool
2024
Jain University
2024
Walton Centre
2024
Abstract Cannabinoid CB 2 receptor (CB R) agonists are investigated as therapeutic agents in the clinic. However, their molecular mode-of-action is not fully understood. Here, we report discovery of LEI-102, a R agonist, used conjunction with three other CBR ligands (APD371, HU308, and CP55,940) to investigate selective activation by binding kinetics, site-directed mutagenesis, cryo-EM studies. We identify key residues for activation. Highly lipophilic HU308 endocannabinoids, but more polar...
The use of biodegradable materials in 3D printing has gained attention due to its potential addressing environmental concerns the manufacturing industry. This paper aims explore current state research and development sustainable using materials. found that materials, such as bioplastics, are being increasingly used an eco-friendly alternative traditional Various types have been tested, including Polylactic Acid (PLA), cellulose-based starch-based One main advantages is reduce carbon...
3D printing has rapidly evolved and matured in recent years, with a key factor being the improvement materials. This paper compares performance applications of various materials, including plastics, metals, ceramics, biomaterials. Plastics remain most widely used material due to their low cost ease printing, while metals are gaining popularity superior mechanical properties. However, advancements ceramic biomaterials have opened up new possibilities for industries such as aerospace,...
The endogenous cannabinoid 2-arachidonoylglycerol (2-AG) plays an important role in a variety of physiologic processes, but its rapid breakdown by monoacylglycerol lipase (MAGL) results short-lived actions. Initial MAGL inhibitors were limited poor selectivity and low potency. In this study, we tested JZL184 [4-nitrophenyl 4-[bis(2<i>H</i>-1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidine-1-carboxylate] MJN110 [2,5-dioxopyrrolidin-1-yl 4-(bis(4-chlorophenyl)methyl)piperazine-1-carboxylate],...
Although paclitaxel effectively treats various cancers, its debilitating peripheral neuropathic pain side effects often persist long after treatment has ended. Therefore, a compelling need exists for the identification of novel pharmacologic strategies to mitigate this condition. As inhibitors monoacylglycerol lipase (MAGL), primary hydrolytic enzyme endogenous cannabinoid, 2-arachidonyolglycerol, produces antinociceptive in numerous rodent models pain, we investigated whether (i.e., JZL184...
The first generation of CB1 positive allosteric modulators (e.g., ZCZ011) featured a 3-nitroalkyl-2-phenyl-indole structure. Although small number drugs include the nitro group, it is generally not regarded as being "drug-like", and this particularly true for aliphatic groups. There are very few case studies where an appropriate bioisostere replaced group that had direct role in binding. This may be indicative difficulty replicating its binding interactions. Herein, we report design...
Pipes are manufactured primarily through the extrusion process. One of material processes in recent digital manufacturing is additive manufacturing’s fusion deposition modeling. made from various materials such as metal and plastic/polymers, main challenge has been selecting pipe for customized application. For creation water-passing tubes, this research chosen appropriate carbon-reinforced polymers that can be used with filament polyether ether ketone (PEEK) polyethylene terephthalate...
The field of 3D printed electronics has been rapidly growing in recent years, with the potential to revolutionize industries such as healthcare, aerospace, and consumer electronics. Polymer printing emerged a promising technique for fabricating electronic devices due its versatility, scalability, cost-effectiveness. However, there are several challenges that need be addressed order fully unlock polymer This research paper discusses current state art this field, highlighting proposing...
Rheumatoid arthritis (RA) is a multifaceted autoimmune disorder characterized by chronic inflammation and joint destruction. Recent research has elucidated the intricate interplay between gut microbiota RA pathogenesis, underscoring role of microbiota‐derived metabolites as pivotal contributors to disease development progression. The human microbiota, comprising vast array microorganisms their metabolic byproducts, plays crucial in maintaining immune homeostasis. Dysbiosis this microbial...