A5000933899- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- HER2/EGFR in Cancer Research
- Calpain Protease Function and Regulation
- Cancer Treatment and Pharmacology
- Nerve injury and regeneration
- Chemotherapy-related skin toxicity
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
Virginia Commonwealth University
2022-2023
Small molecules directly targeting the voltage-gated sodium channel (VGSC) Na
Transmembrane Ca v 2.2 (N-type) voltage-gated calcium channels are genetically and pharmacologically validated, clinically relevant pain targets. Clinical block of (e.g., with Prialt/Ziconotide) or indirect modulation [e.g., gabapentinoids such as Gabapentin (GBP)] mitigates chronic but is encumbered by side effects abuse liability. The cytosolic auxiliary subunit collapsin response mediator protein 2 (CRMP2) targets to the sensory neuron membrane regulates their function via an...
Background: Prior work suggests that patients with vitamin D insufficiency may have a higher risk of chemotherapy-induced peripheral neuropathy (CIPN) from paclitaxel. The objective this study was to validate as CIPN factor. Methods: We used data and samples the prospective phase III SWOG S0221 (ClinicalTrials.gov identifier: NCT00070564 ) trial compared paclitaxel-containing chemotherapy regimens for early-stage breast cancer. quantified pretreatment 25-hydroxy-vitamin in banked serum using...