A5001742006- Preterm Birth and Chorioamnionitis
- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- COVID-19 Impact on Reproduction
- Reproductive System and Pregnancy
- Reproductive tract infections research
- Neonatal Respiratory Health Research
- Maternal and Perinatal Health Interventions
- Neonatal and Maternal Infections
- Ectopic Pregnancy Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Maternal Mental Health During Pregnancy and Postpartum
- Ultrasound Imaging and Elastography
- Urinary Tract Infections Management
- Wnt/β-catenin signaling in development and cancer
- Prenatal Screening and Diagnostics
- Gestational Diabetes Research and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Hyperthermia Applications
- Cardiovascular Issues in Pregnancy
- Parasitic infections in humans and animals
- Legal Rights and Human Rights
- Hedgehog Signaling Pathway Studies
- Neuroscience of respiration and sleep
Beaumont Hospital, Royal Oak
2020-2024
Oakland University
2018-2024
Corewell Health
2024
Cranbrook Academy of Art
2024
Michigan State University
2022-2023
Sparrow Hospital
2023
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2017-2022
National Institutes of Health
2019-2022
Botsford Hospital
2022
Wayne State University
2016-2022
Problem The immune cellular composition of amniotic fluid is poorly understood. Herein, we determined: 1) the immunophenotype cells during second and third trimester in absence intra‐amniotic infection/inflammation; 2) whether T ILCs display different phenotypical characteristics to that peripheral cells; 3) are altered women with infection/inflammation. Method Study Amniotic samples (n = 57) were collected from 15 40 weeks gestation without Samples infection/inflammation also included 9)....
Problem Neutrophils are capable of performing phagocytosis, a primary mechanism for microbial killing. Intra‐amniotic infection is characterized by an influx neutrophils into the amniotic cavity. Herein, we investigated whether fluid could phagocytize bacteria found in cavity women with intra‐amniotic infection. Methods Amniotic from were visualized transmission electron microscopy (n=6). The phagocytic activity and/or inflammation (n=10) or peripheral healthy individuals (controls, n=3) was...
Clinical chorioamnionitis at term is considered the most common infection-related diagnosis in labor and delivery units worldwide. The syndrome affects 5-12% of all pregnancies a leading cause maternal morbidity mortality as well neonatal death sepsis. objectives this study were to determine (1) amniotic fluid microbiology using cultivation molecular microbiologic techniques; (2) diagnostic accuracy clinical criteria used identify patients with intra-amniotic infection; (3) relationship...
Intrahepatic cholestasis of pregnancy is seldom associated with significant vitamin K deficiency. We report a case 16-year-old primigravid patient at 24 weeks and 3 days gestation who presented pruritus, hematuria, preterm labor. Laboratory work-up showed severe coagulopathy Prothrombin Time (PT) 117.8 seconds, International Normalized Ratio (INR) 10.34, elevated transaminases suggestive intrahepatic pregnancy. Her serum level was undetectable (<0.1 nMol/L). Initial therapy consisted...
Background Nonovert disseminated intravascular coagulation (DIC) is a subclinical hemostatic dysfunction that has not yet reached the decompensation stage. The detection of pregnant patients at this stage may assist in identification those who will develop severe obstetrical hemorrhage, as it one leading causes for preventable maternal mortality. Currently, nonovert DIC diagnosed by scoring system based on nonpregnant patients, originally generated International Society Thrombosis and...
Background . Thrombosis of one the umbilical arteries can be associated with adverse pregnancy outcomes such as stillbirth and severe intrauterine growth restriction (IUGR). Case A 21-year-old gravida 1 patient, a history 3-vessel cord at 20 weeks, presented 29 weeks single artery. The estimated fetal weight measurements 26 31 were 27th percentile, 26th less than 5th respectively. At 33 amniotic fluid index became abnormal 2.3 cm heart tracing revealed spontaneous prolonged decelerations,...
Objective Cervical remodeling is an important component in determining the pathway of parturition; therefore, assessing changes cervical tissue composition may provide information about cervix’s status beyond measurement length. Photoacoustic imaging a non-invasive ultrasound-based technology that captures acoustic signals emitted by components response to laser pulses. This optical allows for determination collagen-to-water ratio (CWR). The purpose this study was compare CWR evaluated using...
Background: Chronic and excessive alcohol misuse results in neuroadaptive changes the brain. The complex nature of behavioral, psychological, emotional, neuropathological characteristics associated with alcoholism is likely a reflection network proteins that are affected by alcohol‐induced gene expression patterns specific brain regions. At molecular level, however, knowledge remains limited regarding alterations protein levels chronic abuse. Thus, novel techniques allow comprehensive...
SARS-CoV-2 infection triggers a significant maternal inflammatory response. There is dearth of information regarding whether at admission for delivery or vaccination an response in the fetus. This study aims evaluating fetal to compared control group. Design, Participants, Setting, and Methods: A prospective cohort was performed with total 61 pregnant women who presented single medical center (William Beaumont Hospital, Royal Oak, MI). All mothers were tested using polymerase chain reaction...
<b><i>Background:</i></b> We discuss the ethical decision points in a case report that describes novel COL1A1 mutation associated to Osteogenesis Imperfecta type II, but with non-lethal outcome. <b><i>Case:</i></b> A 33-year-old female underwent 21-week ultrasound revealed short bowed femurs and humeri old fractures tibias fibulas. Amniotic fluid testing (c.1840G&#x3e;A; p.Gly614Arg). OI Type II diagnosis was made. previously reported of...
<b><i>Introduction:</i></b> X-linked recessive mutations predominantly affect male fetuses with milder or no abnormalities in female siblings. Most reports show only one affected member the family. We are reporting a family hydrocephalus, stenosis of aqueduct Sylvius, dysgenesis corpus callosum, and Xp22.33 microduplication. <b><i>Case Presentation:</i></b> Eighteen-year-old patient was evaluated for her 2 pregnancies; first fetus severe...
ABSTRACT Whether the human placenta is a sterile organ under debate. Yet, infection of amniotic cavity, including placenta, causally linked to preterm birth. This study compares bacterial profiles term and placentas through culture 16S rRNA gene sequencing amnion, amnion-chorion interface, subchorion, villous tree, basal plate, while accounting for patient identity, mode delivery, presence/absence labor, potential background DNA contamination. As no evidence placental microbiota in pregnancy...
Cesarean scar pregnancy (CSP) is a very serious complication of prior cesarean delivery. The major risks associated with CSP are uncontrolled hemorrhage and uterine rupture, potentially leading to future infertility. Management remains obstetric challenge without well-defined therapeutic procedure. Dilation & curettage commonly used procedure for the treatment CSP. However, it can be ineffective often leads definite Therefore, we present case successful use an alternative procedure, Myosure®...
INTRODUCTION: Uncontrolled diabetes is a risk factor for cesarean delivery. Identifying and stratifying associated factors failed induction of labor (IOL) may improve counseling intrapartum care. This study aims at determining maternal fetal that would predict the occurrence IOL in diabetic mothers. METHODS: retrospective 2,172 mothers who underwent single university medical center between January 2013 December 2021. Maternal neonatal characteristics were obtained. Among studied ethnicity,...
INTRODUCTION: Maternal diabetes is associated with shoulder dystocia that places the newborn and mother at high risk of morbidity complications. In diabetic population, obstetricians lack definitive predictive factors may improve counseling, preparation, management before delivery. This study evaluates prenatal maternal fetal would predict prior to delivery in mothers. METHODS: a cross-sectional case–control 63 mothers 200 without delivered single medical center between January 2013 December...
Hydatid disease, also known as echinococcosis, is a zoonotic parasitic infection caused by the larvae of Echinococcus tapeworm. It endemic in various regions worldwide, particularly rural areas countries southern South America, Central Asia, China, parts Africa, Mediterranean, and Middle East. The disease primarily affects liver (60-70% cases) lungs (10-25% cases), but it can involve any organ, including brain, bones, rarely pelvic region, seen our case report. typically follows an...
The bladder and urine have historically been considered sterile, especially in the context of clinical assessment. Yet, enhanced culture techniques advances DNA sequencing surveys revealed a low microbial biomass microbiota bladders most healthy individuals. Yet very few studies investigated urinary pregnant women, who are at increased risk tract infections (UTIs) that can lead to pregnancy complications such as spontaneous preterm birth. To better understand potential role during pregnancy,...
Introduction . Incarcerated uterus is a rare complication of pregnancy, usually associated with retroversion. Case A 26-year-old woman presents at 19 4/7 weeks for evaluation short cervix and placenta previa. On ultrasound scan, the was considered previa not visualized. The identified by pelvic examination presumptive diagnosis done. patient followed up closely remained asymptomatic. Retrospective analysis images showed retroverted an elongated compressed towards anterior vaginal wall. At 26...
Invasive group A streptococci infections in pregnancy have historically led to severe maternal and neonatal morbidity mortality. We are reporting a rare novel case of successful treatment third-trimester infection with early, aggressive intervention maintenance the term.A 35 year old woman initially presented fever, flu-like symptoms, preterm contractions at 34 weeks gestation. She demonstrated signs early stages septic shock, ultimately attributed bacteremia. Early, allowed continue until...