A5011726013- Pregnancy and preeclampsia studies
- Preterm Birth and Chorioamnionitis
- Reproductive System and Pregnancy
- Birth, Development, and Health
- Pregnancy-related medical research
- Neonatal Respiratory Health Research
- Maternal and fetal healthcare
- Gestational Diabetes Research and Management
- Prenatal Screening and Diagnostics
- Congenital Heart Disease Studies
- Neonatal and Maternal Infections
- Adipokines, Inflammation, and Metabolic Diseases
- Congenital Diaphragmatic Hernia Studies
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular Issues in Pregnancy
- Fetal and Pediatric Neurological Disorders
- Reproductive tract infections research
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and Medication Impact
- COVID-19 Impact on Reproduction
- Ectopic Pregnancy Diagnosis and Management
- Maternal and Perinatal Health Interventions
- Adipose Tissue and Metabolism
- Fatty Acid Research and Health
- Neonatal and fetal brain pathology
Pontificia Universidad Católica de Chile
2014-2024
Sociedad de Biología de Chile
2023
Wayne State University
2006-2022
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2012-2022
National Institutes of Health
2011-2022
Complejo Asistencial Sótero del Río
2013-2022
Eunice Kennedy Shriver Center
2008-2022
Icesi University
2022
United States Department of Health and Human Services
2007-2021
Sunnybrook Health Science Centre
2018
Abstract Motivation: Gene expression class comparison studies may identify hundreds or thousands of genes as differentially expressed (DE) between sample groups. Gaining biological insight from the result such experiments can be approached, for instance, by identifying signaling pathways impacted observed changes. Most existing pathway analysis methods focus on either number DE in a given (enrichment methods), correlation and samples (functional scoring methods). Both approaches treat simple...
Background Preterm delivery causes substantial neonatal mortality and morbidity. Unrecognized intra-amniotic infections caused by cultivation-resistant microbes may play a role. Molecular methods can detect, characterize quantify independently of traditional culture techniques. However, molecular studies that define the diversity abundance invading amniotic cavity, evaluate their clinical significance within causal framework, are lacking. Methods Findings In parallel with culture, we used...
Introduction. Accumulating evidence suggests that an imbalance between pro-angiogenic (i.e., vascular endothelial growth factor (VEGF) and placental (PlGF)) anti-angiogenic factors soluble VEGF receptor-1 (sVEGFR-1, also referred to as sFlt1)) is involved in the pathophysiology of preeclampsia (PE). Endoglin a protein regulates effects transforming β, its form has recently been implicated PE. The objective this study was determine if changes maternal plasma concentration these angiogenic...
The role played by microbial invasion of the amniotic cavity (MIAC) in preterm pre-labor rupture membranes (pPROM) is inadequately characterized, part because reliance on cultivation-based methods.Amniotic fluid from 204 subjects with pPROM was analyzed both cultivation and molecular methods a retrospective cohort study. Broad-range group-specific polymerase chain reaction (PCR) assays targeted small subunit ribosomal DNA (rDNA), or other gene sequences, bacteria, fungi, archaea. Results...
Objective: The objectives of this study were to: (1) determine the amniotic fluid (AF) microbiology patients with preterm prelabor rupture membranes (PROM); and (2) examine relationship between intra-amniotic inflammation without microorganisms (sterile inflammation) adverse pregnancy outcomes in PROM.
An imbalance between angiogenic and anti-angiogenic factors has been proposed as central to the pathophysiology of preeclampsia (PE). Indeed, patients with PE those delivering small-for-gestational age (SGA) neonates have higher plasma concentrations soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) form endoglin (s-Eng), well lower (VEGF) placental (PlGF) than do normal pregnancies. Of note, this observed before clinical presentation or delivery an SGA neonate. The objective...
Objective: Preeclampsia (PE) has been classified into early- and late-onset disease. These two phenotypic variants of PE have proposed to a different pathophysiology. However, the gestational age cut-off define “early” vs. “late” varied among studies. The objective this investigation was determine prevalence lesions consistent with maternal underperfusion placenta in patients as function age.
Abstract The objectives of this study were: 1) to determine the amniotic fluid (AF) microbiology patients with diagnosis clinical chorioamnionitis at term using both cultivation and molecular techniques; 2) examine relationship between intra-amniotic inflammation without microorganisms placental lesions consistent acute AF infection. samples obtained by transabdominal amniocentesis from 46 women signs were analyzed techniques (for aerobic anerobic bacteria as well genital mycoplasmas)...
Changes in the maternal plasma concentrations of angiogenic (placental growth factor (PlGF) and vascular endothelial (VEGF)) anti-angiogenic factors (sEng receptor-1 (sVEGFR-1)) precede clinical presentation preeclampsia. This study was conducted to examine role PlGF, sEng, sVEGFR-1 early pregnancy midtrimester identification patients destined develop
Preterm parturition is a syndrome caused by multiple etiologies. Although intra-amniotic infection causally linked with intrauterine inflammation and the onset of preterm labor, other patients have labor in absence demonstrable infection. It now clear that may be elicited activation Damage-Associated Molecular Patterns (DAMPs), which include pathogen-associated molecular patterns (PAMPs) as well "alarmins" (endogenous molecules signal tissue cellular damage). A prototypic alarmin...
The co-presence of histoincompatible fetal and maternal cells is a characteristic human placental inflammation. Villitis unknown etiology (VUE), destructive inflammatory lesion villous placenta, characterized by participation Hofbauer (placental macrophages) T cells. In contrast to acute chorioamnionitis infection-related origin, the fundamental immunopathology VUE unknown. This study was performed investigate transcriptome determine whether associated with systemic and/or response(s)....