A5049757454- Pregnancy and preeclampsia studies
- Preterm Birth and Chorioamnionitis
- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Reproductive System and Pregnancy
- Birth, Development, and Health
- Pregnancy-related medical research
- Infant Development and Preterm Care
- Prenatal Screening and Diagnostics
- Maternal and fetal healthcare
- Cardiovascular Issues in Pregnancy
- Gestational Diabetes Research and Management
- Neonatal Health and Biochemistry
- Cerebral Palsy and Movement Disorders
- Family and Disability Support Research
- Neonatal and Maternal Infections
- Thyroid Disorders and Treatments
- IL-33, ST2, and ILC Pathways
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Autism Spectrum Disorder Research
- Assisted Reproductive Technology and Twin Pregnancy
- Anesthesia and Neurotoxicity Research
- Climate Change and Health Impacts
- Infant Nutrition and Health
Wayne State University
2016-2025
Woodward (United States)
2024
RTI International
2023
Brown University
2023
North Carolina State University
2023
Boston College
2023
Michigan United
2016-2021
University Medical Center Groningen
2019
University of Groningen
2019
Michigan State University
2005-2018
Problem Inflammation and infection play a major role in preterm birth. The purpose of this study was to (i) determine the prevalence clinical significance sterile intra-amniotic inflammation (ii) examine relationship between amniotic fluid (AF) concentrations high mobility group box-1 (HMGB1) interval from amniocentesis delivery patients with inflammation. Method AF samples obtained 135 women labor intact membranes were analyzed using cultivation techniques as well broad-range PCR mass...
Objective: The objectives of this study were to: (1) determine the amniotic fluid (AF) microbiology patients with preterm prelabor rupture membranes (PROM); and (2) examine relationship between intra-amniotic inflammation without microorganisms (sterile inflammation) adverse pregnancy outcomes in PROM.
Abstract The objectives of this study were: 1) to determine the amniotic fluid (AF) microbiology patients with diagnosis clinical chorioamnionitis at term using both cultivation and molecular techniques; 2) examine relationship between intra-amniotic inflammation without microorganisms placental lesions consistent acute AF infection. samples obtained by transabdominal amniocentesis from 46 women signs were analyzed techniques (for aerobic anerobic bacteria as well genital mycoplasmas)...
Problem The diagnosis of microbial invasion the amniotic cavity (MIAC) has been traditionally performed using traditional cultivation techniques, which require growth microorganisms in laboratory. Shortcomings culture methods include time required (days) for identification microorganisms, and that many microbes involved genesis human diseases are difficult to culture. A novel technique combines broad‐range real‐time polymerase chain reaction with electrospray ionization time‐of‐flight mass...
To determine the frequency and clinical significance of sterile microbial-associated intra-amniotic inflammation in asymptomatic patients with a sonographic short cervix.
Objectives. To test the hypothesis that law enforcement efforts to disrupt local drug markets by seizing opioids or stimulants are associated with increased spatiotemporal clustering of overdose events in surrounding geographic area. Methods. We performed a retrospective (January 1, 2020 December 31, 2021), population-based cohort study using administrative data from Marion County, Indiana. compared frequency and characteristics (i.e., stimulants) seizures changes fatal overdose, emergency...
Preterm prelabor rupture of membranes (preterm PROM) accounts for 30-40% spontaneous preterm deliveries and thus is a major contributor to perinatal morbidity mortality. An amniotic fluid (AF) interleukin-6 (IL-6) concentration key cytokine the identification intra-amniotic inflammation, patients at risk impending delivery adverse pregnancy complications. The conventional method determine IL-6 concentrations in AF an enzyme-linked immunosorbent assay (ELISA). However, this technique not...
Objective: Preterm birth is associated with 5–18% of pregnancies and the leading cause neonatal morbidity mortality. Amniotic fluid (AF) interleukin-6 (IL-6) a key cytokine for identification intra-amniotic inflammation, patients an elevated AF IL-6 are at risk impending preterm delivery. However, results conventional method measurement (enzyme-linked immunosorbent assay; ELISA) usually not available in time to inform care. The objective this study was determine whether point care (POC) test...
To evaluate cervical stiffness during pregnancy using ultrasound-derived elastography, a method used to estimate the average tissue displacement (strain) within defined region of interest when oscillatory compression is applied.Strain was calculated in two regions interest, endocervical canal and entire cervix, from three anatomical planes cervix: mid-sagittal plane for length measurement cross-sectional located at internal external os. Associations between strain values, ascertainment...
Objective: This study was conducted to examine the frequency and clinical significance of a positive Amnisure test in patients with preterm labor intact membranes by sterile speculum exam. Study design: A retrospective cohort performed including 90 who underwent tests prior amniocentesis (< 72 h); most (n = 64) also fetal fibronectin (fFN) tests. Amniotic fluid (AF) cultured for aerobic/anaerobic bacteria genital mycoplasmas assayed matrix metalloproteinase-8. Results: (1) prevalence 19%...
Abstract Recent studies indicate that clinical chorioamnionitis is a heterogeneous condition and only approximately one-half of the patients have bacteria in amniotic cavity, which often associated with intra-amniotic inflammation. The objective this study to characterize nature inflammatory response within cavity at term according presence or absence 1) 2) A retrospective cross-sectional case-control was conducted examine cytokine chemokine concentrations fluid (AF). Cases consisted women...
The diagnosis of clinical chorioamnionitis is based on a combination signs [fever, maternal or fetal tachycardia, foul-smelling amniotic fluid (AF), uterine tenderness and leukocytosis]. Bacterial infections within the cavity are considered most frequent cause an indication for antibiotic administration to reduce neonatal morbidity. Recent studies show that only 54% patients with at term have bacteria in AF evidence intra-amniotic inflammation. objective this study was examine performance...
Abstract We sought to determine whether cumulative evidence of perinatal inflammation was associated with increased risk in a “multi-hit” model neonatal white matter injury (WMI). This retrospective cohort study included very preterm (gestational ages at delivery <32 weeks) live-born singleton neonates delivered Hutzel Women’s Hospital, Detroit, MI, from 2006 2011. Four pathologists blinded clinical diagnoses and outcomes performed histological examinations according standardized...
Multiple sclerosis (MS) patients have been considered a higher-risk population for COVID-19 due to the high prevalence of disability and disease-modifying therapy use; however, there is little data identifying clinical characteristics MS associated with worse outcomes. Therefore, we conducted multicenter prospective cohort study looking at outcomes 40 confirmed COVID-19. Severity infection was based on hospital course, where mild course defined as patient not requiring admission, moderate...
Objective: To assess the diagnostic performance of transabdominal sonographic measurement cervical length in identifying patients with a short cervix. Methods: Cervical was measured 220 pregnant women using and transvaginal ultrasound (US). Reproducibility agreement between within both methods were assessed. The accuracy US for cases <25 mm evaluated. Results: Twenty-one out (9.5%) had by US. Only 43% (n = 9) cervix correctly identified In US, overestimated this parameter an average 8 (95%...
Acute atherosis is characterized by subendothelial lipid-filled foam cells, fibrinoid necrosis and perivascular lymphocytic infiltration. This lesion generally confined to non-transformed spiral arteries frequently observed in patients with preeclampsia. However, the frequency of acute great obstetrical syndromes unknown. The purpose this study was determine topographic distribution placentas placental bed biopsy samples obtained from women normal pregnancy those affected "great syndromes"....
Massive perivillous fibrin deposition (MPFD) and maternal floor infarction (MFI) are related placental lesions often associated with fetal death growth restriction. A tendency to recur in subsequent pregnancies has been reported. This study was conducted determine whether this complication of pregnancy could reflect antifetal rejection.Pregnancies MPFD were identified (n = 10). Controls consisted women uncomplicated who delivered at term without 175). Second-trimester plasma analyzed for...