A5021269581- Pregnancy and preeclampsia studies
- Preterm Birth and Chorioamnionitis
- Birth, Development, and Health
- Pregnancy-related medical research
- Gestational Diabetes Research and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
- Neonatal Respiratory Health Research
- Maternal and Perinatal Health Interventions
- Reproductive System and Pregnancy
- Liver Disease Diagnosis and Treatment
- Maternal and fetal healthcare
- Ectopic Pregnancy Diagnosis and Management
- Pregnancy and Medication Impact
- Reproductive tract infections research
- Parvovirus B19 Infection Studies
- Cardiovascular Issues in Pregnancy
- Congenital Diaphragmatic Hernia Studies
- Bariatric Surgery and Outcomes
- Global Maternal and Child Health
- Ovarian cancer diagnosis and treatment
- Endometriosis Research and Treatment
- Congenital Heart Disease Studies
- Pelvic floor disorders treatments
- Maternal Mental Health During Pregnancy and Postpartum
Seoul National University
2016-2025
Seoul National University Hospital
2016-2025
New Generation University College
2011-2025
University of Pennsylvania
2020-2024
Keimyung University
2024
National University College
2024
Kyungpook National University Hospital
2020-2023
Beijing Obstetrics and Gynecology Hospital
2011-2019
Seonam University
2019
Boramae Medical Center
2011-2018
Endothelial dysfunction is defined as impairment of the balance between endothelium-dependent vasodilation and constriction. Despite evidence uric acid-induced endothelial dysfunction, a relationship with insulin resistance has not been clearly established. In this study, we investigated role vascular in dysfunction. Uric acid inhibited insulin-induced nitric oxide synthase (eNOS) phosphorylation NO production more substantially than endothelin-1 expression HUVECs, IC50 51.0, 73.6, 184.2,...
Low socioeconomic status can increase the risk of adverse pregnancy outcomes, but it remains unclear whether this negative association is attributed to inadequate prenatal care. Korea has been adopting a universal healthcare system. All Korean citizens must be enrolled National Health Insurance (NHI) or recipient Medical Aid (MA). In addition, government launched financial support system for antenatal care all pregnant women in 2008. Therefore, theory, there no barrier receive cares...
Objective. The Amnisure ROM™ test is approved for the diagnosis of rupture membranes (ROM). Yet, a fraction patients with positive have intact by sterile speculum examination. objective this study was to determine clinical significance finding.Methods. population consisted four groups nulliparous women at term: (1) not in labor without evidence ROM (n = 125); (2) negative test™ 56); (3) 25); and (4) 30). performed cases (Groups 1, 2 3).Results. more frequently than term (30.9% (25/81 women)...
Objective: This study was conducted to examine the frequency and clinical significance of a positive Amnisure test in patients with preterm labor intact membranes by sterile speculum exam. Study design: A retrospective cohort performed including 90 who underwent tests prior amniocentesis (< 72 h); most (n = 64) also fetal fibronectin (fFN) tests. Amniotic fluid (AF) cultured for aerobic/anaerobic bacteria genital mycoplasmas assayed matrix metalloproteinase-8. Results: (1) prevalence 19%...
Objective Much controversy still exists about maternal-to-infant transmission of human papillomavirus (HPV) infection, specifically the magnitude risk and route timing such vertical transmission. This prospective cohort study examines maternal HPV in each trimester pregnancy. Study design One hundred fifty three healthy pregnant women were followed longitudinally throughout pregnancy cervical swabs obtained postpartum for detection. Cord blood, neonatal nasopharyngeal aspirates, placental...
Abstract Background Previous studies showed that gestational diabetes mellitus (GDM) can be a risk factor for subsequent atherosclerotic cardiovascular disease. However, there is paucity of information regarding diverse outcomes in elderly women after GDM. In the current study, we examined whether with history GDM have an increased long-term overall outcomes. Methods Among UK participants, included 219,330 aged 40 to 69 years who reported at least one live birth. The new incidence was...
Pre-eclampsia (PE) is a pregnancy disorder that related to an enhanced immune response. Immune cell characteristics such as neutrophil or monocyte lymphocyte ratios (NLR, MLR) are known be kidney and liver dysfunction in hypertensive patients. Here, we aimed analyze the correlations between NLR, MLR platelet ratio (PLR) liver, renal coagulation functional parameters impacts of these profiles prognostic significance PE patients.Pre-delivery hematological biochemical 320 first-time pregnant...
Objective. To examine the frequency and risk factors of funisitis histologic chorioamnionitis in placentas term pregnant women who delivered after spontaneous onset labor.Methods. The was examined consecutive at with singleton pregnancies labor. Nonparametric statistics were used for data analysis.Results. (1) 6.7% (88/1316) 23.6% (310/1316), respectively; (2) Patients had significantly higher rates nulliparity, regional analgesia, operative vaginal delivery, longer duration labor rupture...
Background The objective of this study was to determine whether acute histologic chorioamnionitis is associated with adverse neonatal outcomes in late preterm infants who were born after PROM. Methodology/Principal Findings relationship between the presence and outcome examined patients PROM delivered singleton newborns 34 weeks 36 6/7 gestation. Nonparametric statistics used for data analysis. frequency 24% Newborns mothers had significantly higher rates (74% vs 51%; p<0.005) than those...
BACKGROUND: Extensive physiological and biological emphasis has been placed on pharmaceutical medicinal uses of mushrooms containing β-glucans, but their incorporation into processed functional foods is quite limited. Thus, low-grade Lentinus edodes were utilised to produce β-glucan-enriched materials (BGEMs), which evaluated as a high-fibre low-calorie substitute for wheat flour. RESULTS: The fractions obtained from contained 514 g kg−1 (1–3)-β-glucans with (1–6)-β-linked side chains the...
Background and objectives Although hemodynamic adaptation plays a crucial role in maintaining gestation, the clinical significance of midterm renal hyperfiltration (MRH) on pregnancy outcomes is unknown. Design, setting, participants, & measurements This was an observational cohort study. Women with singleton serum creatinine measurement during their second trimester were followed at two university hospitals Korea between 2001 2015. Those substantial function impairment or who delivered...
Here, we investigated whether cytokines in the cervicovaginal fluid (CVF) can be predictive markers of preterm birth (PTB). A multi-center prospective cohort study was conducted on 59 singleton pregnant women hospitalized for labor (PTL) and/or premature rupture membranes (pPROM) between 22 weeks and 36 6 days gestation from 2014 to 2015. The levels 13 inflammatory (macrophage protein [MIP]-1α, MIP-1β, tumor necrosis factor [TNF]-α, interleukin [IL]-1β, IL-6, IL-8, IL-17α, granulocyte colony...
Aims: The purpose of this study was to determine if a bedside test, the MMP-8 PTD Check™, can be value in antenatal identification funisitis. This test performed 15 min without any laboratory equipment.
Objective. The purpose of this study was to determine whether there is a relationship between the frequency meconium-stained amniotic fluid (MSAF) and duration labor in term singleton gestation.Methods. clinical characteristics women who delivered live newborns 2001 2006 were examined. cases involving neonates with major congenital anomalies excluded.Results. (1) MSAF pregnancies 18.4% (806/4376); (2) found only 2.8% (28/1008) by elective cesarean, but 23.1% (778/3368) after onset (p <...
Nonalcoholic fatty liver disease (NAFLD) is a well-recognized hepatic manifestation of metabolic in adults and has been associated with the development gestational diabetes (GDM). Hepatic insulin resistance can result increased release glucose (from gluconeogenesis) free acids (due to enhanced lipolysis), which lead turn fetal overgrowth. However, relationship between maternal factors (such as circulating levels triglycerides, [FFA], or adipokines) excessive birthweight NAFLD not carefully...
Abstract Problem The stability and dominance of Lactobacillus spp. in vaginal fluid are important for reproductive health. However, the characterization microbiota women with preterm labor (PTL) or premature rupture membranes (P‐PROM), its association birth (PTB) poorly understood. Method study We collected from at risk PTB (n = 58) five university hospitals Korea. performed a hierarchical clustering analysis classification according to abundance using Illumina MiSeq sequencing 16S rRNA gene...
The genetic risk for hypertensive disorders of pregnancy is linked with the development atherosclerotic cardiovascular disease. However, effects lifestyle and metabolic syndrome on disease have not been evaluated. Here, we assess long-term association between these factors in women pregnancy. We evaluate using a genome-wide polygenic score derived from large-scale GWAS. incidence evaluated according to risk, lifestyle, syndrome. Individuals very high 53.0% higher chance developing than those...
Abstract Background This study aims to identify early metabolomic biomarkers of gestational diabetes mellitus (GDM) and evaluate their association with hepatic steatosis. Methods We compared maternal serum profiles between women who developed GDM ( n = 118) matched controls during the first (10–14 weeks) second (24–28 trimesters using ultra-performance liquid chromatography coupled mass spectrometry. Mediation analysis was performed mediating role metabolic dysfunction-associated steatotic...
<title>Abstract</title> We hypothesized that incorporating postnatal dynamic factors would enhance the prediction accuracy of bronchopulmonary dysplasia in preterm infants. This retrospective cohort study included neonates born before 32 weeks gestation at Seoul National University Hospital between 2013 and 2022. The primary outcome was moderate or severe dysplasia. assessed both static perinatal risk factors, such as respiratory support type, inspired oxygen concentration, blood gas...
Previous studies reported that the clinical significance of intra-amniotic inflammation with a negative amniotic fluid (AF) culture is similar to microbiologically-proven AF infection. However, magnitude fetal inflammatory response in these two conditions different as gauged by umbilical cord C-reactive protein (CRP) concentrations. We undertook this study determine if frequency oligohydramnios conditions.The index (AFI) was measured 205 patients preterm premature rupture membranes (PROM)...