A5074131210- Pregnancy and preeclampsia studies
- Preterm Birth and Chorioamnionitis
- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
- Neonatal Respiratory Health Research
- Pregnancy-related medical research
- Birth, Development, and Health
- Ectopic Pregnancy Diagnosis and Management
- Gestational Diabetes Research and Management
- Reproductive System and Pregnancy
- Cardiovascular Issues in Pregnancy
- Maternal and Perinatal Health Interventions
- Fetal and Pediatric Neurological Disorders
- Congenital Diaphragmatic Hernia Studies
- Maternal and fetal healthcare
- Congenital Anomalies and Fetal Surgery
- Neonatal and fetal brain pathology
- Congenital Heart Disease Studies
- Parvovirus B19 Infection Studies
- Neonatal and Maternal Infections
- Pregnancy and Medication Impact
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Urological Disorders and Treatments
Seoul National University
2016-2025
New Generation University College
2005-2025
Seoul National University Hospital
2013-2024
Institute of Reproductive Medicine
2010-2019
Kangwon National University
2015
Inha University Hospital
2015
Asan Medical Center
2010
Yale University
2007
Society for Maternal-Fetal Medicine
2007
Objective: Antibiotic administration is a standard practice in preterm premature rupture of membranes (PROM). Specific anti-microbial agents often include ampicillin and/or erythromycin. Anaerobes and genital mycoplasmas are frequently involved PROM, but not adequately covered by antibiotics routinely used clinical practice. Our objective was to compare outcomes PROM treated with antibiotic versus new combination more effective against these bacteria.Study design: A retrospective study...
In Brief OBJECTIVE: To compare the accuracy of an immunoassay to measure levels placental alpha-microglobulin-1 in cervicovaginal secretions with that conventional clinical assessment for diagnosis rupture membranes. METHODS: A prospective observational study was performed consecutive patients signs or symptoms membranes at Seoul National University Hospital from March 2005 February 2006. Initial evaluation included both standard and immunoassay. Rupture diagnosed if fluid seen leaking...
Objective: Acute histologic chorioamnionitis (HCA) is associated with an increased risk of perinatal mortality and morbidity. The purpose this study was to determine the relationship between intensity intra-amniotic inflammation (IAI) severity acute HCA in preterm gestation.Methods: IAI presence examined 412 patients singleton gestations who delivered within 120 h transabdominal amniocentesis. concentration amniotic fluid (AF) matrix metalloproteinase (MMP)-8 assayed IAI. defined as...
Abstract Background Previous studies showed that gestational diabetes mellitus (GDM) can be a risk factor for subsequent atherosclerotic cardiovascular disease. However, there is paucity of information regarding diverse outcomes in elderly women after GDM. In the current study, we examined whether with history GDM have an increased long-term overall outcomes. Methods Among UK participants, included 219,330 aged 40 to 69 years who reported at least one live birth. The new incidence was...
Abstract Somatic cells accumulate genomic alterations with age; however, our understanding of mitochondrial DNA (mtDNA) mosaicism remains limited. Here we investigated the genomes 2,096 clones derived from three cell types across 31 donors, identifying 6,451 mtDNA variants heteroplasmy levels ≳0.3%. While majority these were unique to individual clones, suggesting stochastic acquisition age, 409 (6%) shared multiple embryonic lineages, indicating their origin in fertilized eggs. The...
Objective: The purpose of this study was to determine whether concentrations C-reactive protein (CRP) in umbilical cord plasma at birth were elevated neonates with sepsis, an inflammatory lesion the (funisitis) or who born mothers microbial invasion amniotic cavity. Methods: Umbilical collected from 313 singleton preterm (20-35 weeks gestation). results fluid culture performed within 5 days birth, occurrence congenital neonatal sepsis and presence funisitis assessed. Amniocentesis 152...
BACKGROUND: Vascular endothelial growth factor (VEGF) is known to play a pivotal role in the development of endometriosis. This study was performed investigate whether VEGF gene 5’-untranslated region polymorphism associated with susceptibility advanced stage METHODS: comprised 215 women endometriosis, 219 control without and 70 fertile women. Following extraction genomic DNA, genotyping −460 C/T +405 C/G polymorphisms were by polymerase chain reaction (PCR) restriction fragment length...
Background The objective of this study was to determine whether acute histologic chorioamnionitis is associated with adverse neonatal outcomes in late preterm infants who were born after PROM. Methodology/Principal Findings relationship between the presence and outcome examined patients PROM delivered singleton newborns 34 weeks 36 6/7 gestation. Nonparametric statistics used for data analysis. frequency 24% Newborns mothers had significantly higher rates (74% vs 51%; p<0.005) than those...