A5010886480- Genetic Associations and Epidemiology
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Gestational Diabetes Research and Management
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Genomics and Rare Diseases
- Diabetes and associated disorders
- Pregnancy and preeclampsia studies
- Liver Disease Diagnosis and Treatment
- Bariatric Surgery and Outcomes
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Nutrition, Genetics, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Diabetes Management and Education
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Genetic Syndromes and Imprinting
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Genetics and Neurodevelopmental Disorders
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
Seoul National University
2016-2025
Seoul National University Hospital
2016-2025
New Generation University College
2009-2024
Broad Institute
2020-2024
Massachusetts General Hospital
2023-2024
Seonam University
2018-2024
Soonchunhyang University Hospital
2023
Asan Medical Center
2023
National University College
2023
Daegu University
2023
The number of people with metabolic syndrome is increasing worldwide, and changes in socioenvironmental factors contribute to this increase. Therefore, investigation its components South Korea, where rapid have occurred recent years, would be foundational setting up an effective strategy for reducing trend.We compared the prevalence pattern among participants Korean National Health Nutrition Examination Surveys 1998, 2001, 2005, 2007. In each survey, stratified, multistage,...
The dysregulation of adipokines is closely associated with the pathogenesis insulin resistance and type 2 diabetes. Retinol-binding protein-4 (RBP4), a new adipokine, was recently reported to provide link between obesity resistance. Here, we examined relation plasma RBP4 concentrations various metabolic parameters in humans.An enzyme-linked immunosorbent assay developed measure human concentrations, which were then compared related subjects normal glucose tolerance (NGT; n = 57), impaired...
Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals with type 2 diabetes (T2D) and 24,440 non-diabetic control participants from 5 ancestries. We identify gene-level associations rare (with minor allele frequencies less than 0.5%) in 4 genes at exome-wide significance, including a series more 30 SLC30A8 alleles conveys protection against T2D, 12 gene sets, those...
Knowledge regarding the genetic risk loci for gestational diabetes mellitus (GDM) is still limited. In this study, we performed a two-stage genome-wide association analysis in Korean women. stage 1 genome scan, 468 women with GDM and 1,242 nondiabetic control were compared using 2.19 million genotyped or imputed markers. We selected 11 further genotyping 2 samples of 931 case 783 subjects. The joint effect plus studies was analyzed by meta-analysis. also investigated known type variants GDM....
// Seungbok Lee 1, * , Ha Young Park 2, So Kang 3 Seok Jin Kim 4 Jinha Hwang 2 Seungho 7 Soo Heon Kwak 5 Kyong 5, 6 Hae Yong Yoo Won Seog 4, Jong-Il 8, Hyeh Ko 3, 1 Genomic Medicine Institute (GMI), Medical Research Center, Seoul National University, Seoul, Korea Department of Biomedical Sciences, University Graduate School, Pathology, Samsung Sungkyunkwan School Medicine, Division Hematology-Oncology, Internal Hospital, Molecular and Biopharmaceutical Convergence Science Technology College...
Women with a history of gestational diabetes mellitus (GDM) are at increased risk type 2 (T2DM). However, the time to progression differs individually.We investigated clinical and genetic factors that associated T2DM early or late post partum after GDM pregnancy.This was hospital-based prospective cohort study enrolled women.A total 843 subjects were followed for development T2DM. Clinical during pregnancy, months partum, annually thereafter. genotyped 21 known T2DM-associated variants,...
Abstract Aims Proprotein convertase subtilisin/kexin type-9 (PCSK9), a molecular determinant of low-density lipoprotein (LDL) receptor (LDLR) fate, has emerged as promising therapeutic target for atherosclerotic cardiovascular diseases. However, the precise mechanism by which PCSK9 regulates internalization and lysosomal degradation LDLR is unknown. Recently, we identified adenylyl cyclase-associated protein 1 (CAP1) human resistin whose globular C-terminus structurally similar to C-terminal...
Abstract The prevalence of youth-onset type 2 diabetes (T2D) and childhood obesity has been rising steadily 1 , producing a growing public health concern that disproportionately affects minority groups . genetic basis T2D its relationship to other forms are unclear 3 Here we report detailed characterization by analysing exome sequences common variant associations for 3,005 individuals with 9,777 adult control participants matched ancestry, including both males females. We identify monogenic...
Objective Vaspin is visceral adipose-tissue-derived adipokine, which has an insulin-sensitizing effect in obese type 2 diabetic rodent models. As adipokines may serve as a link between adiposity and atherosclerosis, we investigated whether plasma vaspin concentrations were associated with the metabolic syndrome coronary atherosclerosis. Design Methods We measured fasting levels 81 subjects 241 age- sex-matched control without using enzyme-linked immunosorbent assay. Multi-detector row...
Abstract Thyroid cancer is the most common in Korea. Several susceptibility loci of differentiated thyroid (DTC) were identified by previous genome-wide association studies (GWASs) Europeans only. Here we conducted a GWAS and replication study Koreans using total 1,085 DTC cases 8,884 controls, validated these results expression quantitative trait (eQTL) analysis clinical phenotypes. The robust associations observed NRG1 gene (rs6996585, P =1.08 × 10 −10 ) this SNP was also associated with...
OBJECTIVE This study evaluated the efficacy of a smartphone-based, patient-centered diabetes care system (mDiabetes) for type 2 that contains comprehensive modules glucose monitoring, diet, physical activity, and clinical decision support system. RESEARCH DESIGN AND METHODS We conducted 24-week, multicenter, randomized controlled trial with adult patients inadequately diabetes. The were randomly assigned to mDiabetes group or paper logbook (pLogbook) group. primary end point was difference...
Abstract Background Previous studies showed that gestational diabetes mellitus (GDM) can be a risk factor for subsequent atherosclerotic cardiovascular disease. However, there is paucity of information regarding diverse outcomes in elderly women after GDM. In the current study, we examined whether with history GDM have an increased long-term overall outcomes. Methods Among UK participants, included 219,330 aged 40 to 69 years who reported at least one live birth. The new incidence was...
While the triglyceride-glucose (TyG) index is a measure of insulin resistance, its association with cardiovascular disease (CVD) has not been well elucidated. We evaluated TyG for prediction CVDs in prospective large communitybased cohort.Individuals 40 to 70 years old were prospectively followed median 15.6 years. The was calculated as Ln [fasting triglycerides (mg/dL)×fasting glucose (mg/dL)/2]. included any acute myocardial infarction, coronary artery or cerebrovascular disease. used Cox...