A5030222404- Pancreatic function and diabetes
- Gestational Diabetes Research and Management
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Reproductive Biology and Fertility
- Bariatric Surgery and Outcomes
- Adipose Tissue and Metabolism
- Animal Genetics and Reproduction
- Diet, Metabolism, and Disease
- Diabetes Management and Research
- Pregnancy and preeclampsia studies
- Diabetes and associated disorders
- Nutrition and Health in Aging
- Metabolism, Diabetes, and Cancer
- Pluripotent Stem Cells Research
- Sperm and Testicular Function
- Birth, Development, and Health
- Diet and metabolism studies
- Ovarian function and disorders
- Tissue Engineering and Regenerative Medicine
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease and Transplantation
- Pancreatic and Hepatic Oncology Research
- Neurotransmitter Receptor Influence on Behavior
Seoul National University Bundang Hospital
2015-2025
Seoul National University
2015-2025
Armed Forces Capital Hospital
2025
New Generation University College
2023-2024
Ruhr University Bochum
2024
St. Josef-Hospital
2024
Katholisches Klinikum Bochum
2024
Universitätsmedizin Greifswald
2024
Hallym University Dongtan Sacred Heart Hospital
2024
National University College
2023
Intermittent fasting (IF), a periodic energy restriction, has been shown to provide health benefits equivalent prolonged or caloric restriction. However, our understanding of the underlying mechanisms IF-mediated metabolic is limited. Here we show that isocaloric IF improves homeostasis against diet-induced obesity and dysfunction primarily through adipose thermogenesis in mice. IF-induced require fasting-mediated increases vascular endothelial growth factor (VEGF) expression white tissue...
Abstract Aims To evaluate whether sodium‐glucose cotransporter‐2 (SGLT2) inhibition reduces cellular senescence in the kidney and to investigate molecular pathways involved renoprotective effect. Materials methods Dapagliflozin (1 mg/kg), glimepiride (2.5 mg/kg) or vehicle was administered daily via oral gavage for 8 weeks db/db mice. Expression levels of ageing marker genes (p21, p16, p53) oxidative stress were measured using real‐time RT‐PCR, immunohistochemistry, Western blot analysis....
Lactation benefits women’s metabolic health by improving pancreatic β cell mass and function through serotonin production in cells.
We investigated the effect of metabolic dysfunction-associated fatty liver disease (MAFLD) on future mortality and cardiovascular (CVD) using a prospective community-based cohort study.Individuals from two cohorts who were 40 to 70 years old prospectively followed for 16 years. MAFLD was defined as high index (FLI ≥60) plus one following conditions: overweight/obesity (body mass ≥23 kg/m2), type 2 diabetes mellitus, or ≥2 risk abnormalities. Nonalcoholic (NAFLD) FLI ≥60 without any secondary...
While the triglyceride-glucose (TyG) index is a measure of insulin resistance, its association with cardiovascular disease (CVD) has not been well elucidated. We evaluated TyG for prediction CVDs in prospective large communitybased cohort.Individuals 40 to 70 years old were prospectively followed median 15.6 years. The was calculated as Ln [fasting triglycerides (mg/dL)×fasting glucose (mg/dL)/2]. included any acute myocardial infarction, coronary artery or cerebrovascular disease. used Cox...
<h3>Background and Objectives:</h3> For diagnostic lumbar medial-branch blocks, fluoroscopic guidance is considered mandatory, but this technique comes with radiation exposure. The clinical feasibility of the ultrasound-guided block has been demonstrated. We evaluated success rate validity new method by use fluoroscopy controls in patients previously diagnosed facet joint-mediated pain. <h3>Methods:</h3> In 20 patients, 101 blocks were performed under ultrasound guidance. target point was...
Kisspeptin (Kp) is best known as a multifunctional peptide with roles in reproduction, the cardiovascular system and cancer. In present study expression of kisspeptin hierarchy elements (KISS1, GNRH1 LHB) their receptors (KISS1R, GNRHR LHCGR, respectively) porcine ovary cumulus-oocyte complexes (COCs) were investigated, its effects on vitro maturation (IVM) oocytes subsequent ability to sustain preimplantation embryo competence after parthenogenetic electrical activation. Kp expressed...
Quercetin (QT) and taxifolin (TF) are structurally similar plant-derived flavonoids that have antioxidant properties act as free radical scavengers. The objective of this study was to investigate effects QT TF on nuclear maturation porcine oocytes. Effects at 0, 1, 10, 50 μg/mL oocyte (polar body extrusion) were investigated. After incubation for 44 h, there no significant differences between the treatment control groups except in group which significantly lower (59.2%, p<0.05) than other...
The effect of weight gain on the development type 2 diabetes after gestational mellitus (GDM) is not fully understood in Asian women who have a relatively low body mass index (BMI). We investigated postpartum longitudinal BMI change Korean with history GDM. study included hospital-based, multicenter, prospective cohort median follow-up 4.0 years. A total 418 previous GDM or impaired glucose tolerance were recruited and underwent an oral test at 6 weeks annually thereafter. risk was analyzed...
Abstract Ambulatory blood pressure (BP) monitoring is recommended to improve the management of hypertension. Here, we investigated accuracy BP estimated using a wearable cuff-less device, InBodyWATCH, compared with measured manual sphygmomanometer. Thirty-five adults were enrolled (age 57.1 ± 17.9 years). The was InBodyWATCH an individualized estimation based on neural network model. Three paired sets BPs from two devices correlation analysis and Bland–Altman plots ( n = 105 readings)....
Sarcopenia is an independent risk factor not only for advanced-stage non-alcoholic fatty liver disease (NAFLD) but also mortality. We investigated the association of sarcopenia and/or NAFLD with mortality among Korean general population.Individuals aged 35-75 years without any history cancer, ischaemic heart disease, stroke, or secondary causes chronic were selected from National Health and Nutrition Examination Surveys 2008 to 2015. Their data until December 2018 retrieved Death Registry....
Although oxidative stress is the main pathophysiology of development diabetic neuropathy, oral administration antioxidants has given disappointing results. Here, we hypothesized that local delivery would provide protective effects on Schwann cells due to high concentration lesions. We prepared alpha-tocopherol (ATF)-loaded liposomes and tested their skin penetration after sonication. An in vitro study using IMS-32 was conducted determine level reactive oxygen species (ROS) scavenging...
Abstract Background This study aims to identify early metabolomic biomarkers of gestational diabetes mellitus (GDM) and evaluate their association with hepatic steatosis. Methods We compared maternal serum profiles between women who developed GDM ( n = 118) matched controls during the first (10–14 weeks) second (24–28 trimesters using ultra-performance liquid chromatography coupled mass spectrometry. Mediation analysis was performed mediating role metabolic dysfunction-associated steatotic...
The association of low vitamin D status with mild cognitive impairment (MCI), a preclinical condition that can lead to dementia, has not yet been fully explored. Our aim was investigate the between and future risk MCI dementia in older adults.We conducted population-based prospective study as part Korean Longitudinal Study on Health Aging. Four hundred twelve elderly participants who completed evaluations function metabolic parameters 2005-2006 2010-2011 were analysed.The rate development or...