A5101610261- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Titanium Alloys Microstructure and Properties
- Orthopaedic implants and arthroplasty
- Facial Trauma and Fracture Management
- Plant Stress Responses and Tolerance
- Diabetes Management and Research
- CRISPR and Genetic Engineering
- Additive Manufacturing Materials and Processes
- Virus-based gene therapy research
- Transgenic Plants and Applications
- Photosynthetic Processes and Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Plant tissue culture and regeneration
- Growth Hormone and Insulin-like Growth Factors
- Diabetes Management and Education
- Thin-Film Transistor Technologies
- Alzheimer's disease research and treatments
- Plant biochemistry and biosynthesis
- Pituitary Gland Disorders and Treatments
- Diabetes Treatment and Management
- GDF15 and Related Biomarkers
- Plant Molecular Biology Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
Chonnam National University
2014-2024
Chung-Ang University
2015-2024
Chonnam National University Hospital
2023
Korea Basic Science Institute
2014-2023
Seoul St. Mary's Hospital
2023
Catholic University of Korea
2023
Eulji University
2022
Massachusetts Institute of Technology
2022
Yonsei University
2006-2021
University of Colorado Anschutz Medical Campus
2020-2021
Metastatic cancers have historically been difficult to treat. However, metastatic tumors found high levels of reactive oxygen species such as hydrogen peroxide (H2O2), supporting the hypothesis that a prodrug could be activated by intracellular H2O2 and lead potential antimetastatic therapy. In this study, 7 was designed H2O2-mediated boronate oxidation, resulting in activation fluorophore for detection release therapeutic agent, SN-38. Drug from investigated monitoring fluorescence after...
The aim of this study was to analyze the available knowledge about potential association between dyslipidemia and severity coronavirus disease 2019 (COVID-19) as reported in previous published systematic reviews.
IGF-1 receptor (IGF-1R) signaling is implicated in cardiac hypertrophy and longevity. However, the role of IGF-1R age-related remodeling only partially understood. We therefore sought to determine whether deletion cardiomyocytes might delay development aging-associated myocardial pathologies by examining 2-year-old male cardiomyocyte-specific knockout (CIGF1RKO) mice. Aging was associated with induction expression hearts. Cardiomyocytes hypertrophied age wild-type (WT) In contrast,...
Described here is the development of gadolinium(III) texaphyrin-platinum(IV) conjugates capable overcoming platinum resistance by 1) localizing to solid tumors, 2) promoting enhanced cancer cell uptake, and 3) reactivating p53 in platinum-resistant models. Side side comparative studies these Pt(IV) clinically approved platinum(II) agents previously reported platinum(II)-texaphyrin demonstrate that present are more stable against hydrolysis nucleophilic attack. Moreover, they display high...
Viruslike particles (VLPs) fabricated using wireframe DNA origami are emerging as promising vaccine and gene therapeutic delivery platforms due to their programmable nature that offers independent control over size shape, well site-specific functionalization. As materials biodegrade in the presence of endonucleases, specifically DNase I II, utility for targeting cells, tissues, organs depends on stability vivo. Here, we explore minor groove binders (MGBs) specific endonuclease inhibitors...
Preparation of a revised simulated body fluid (R-SBF) with ion concentrations, including those Cl{sup -} and HCO{sub 3}{sup -}, equal to the human blood plasma was attempted. Ion concentrations prepared SBF were confirmed be plasma. The unchanged at least for 4 weeks, when R-SBF sealed in polystyrene container stored 36.5 C. is believed produce apatite composition structure bone apatite, thereby being useful vitro assessment bioactivity material biomimetic synthesis bonelike apatite. (orig.)
Ascorbate is an essential antioxidant substance for humans. Due to the lack of ascorbate biosynthetic enzyme, a human must intake from food source. Tomato one most widely consumed fruits, thus elevation content in tomato fruits will improve their nutritional value. Here we characterized Solanum lycopersicum ASCORBATE PEROXIDASE 4 (SlAPX4) as gene specifically induced during fruit ripening. In tomatoes, accumulates yellow stage then decreases later stages To investigate whether SlAPX involved...
Dynamic kinetic resolutions (DKRs) of secondary alcohols by lipase–ruthenium or subtilisin–ruthenium combo-catalysis were successfully accomplished in an ionic liquid, [BMIM]PF6 ([BMIM] = 1-butyl-3-methylimidazolium), the presence acyl donor to provide (R)- (S)-esters high optical purities good yields. Ionic liquid as solvent was essential for successful performance DKRs at room temperature since its use enhanced activity racemizing ruthenium catalyst.
Background: The aim of the present study was to investigate serum levels endothelial progenitor cells (EPCs) in type 2 diabetic patients without documented ischemic disease and association between EPCs atherosclerotic plaque formation carotid artery. Methods Results: A clinic-based, prospective conducted. total 73 subjects were enrolled this after cardiac magnetic resonance imaging ankle-brachial index measurements exclude with disease. Plaque artery measured on ultrasonography. Circulating...
Thiazolidinediones, such as rosiglitazone or pioglitazone, are anti-diabetic agents that have been expected to show a beneficial effect in Alzheimer's disease (AD) because of their anti-inflammatory effect. However, these failed significant on AD recent clinical trials. Here, we suggest low-dose treatment, and not the conventional doses, has an amyloid β (Aβ)-clearing by increasing LRP1, Aβ outward transporter blood-brain barrier. Rosiglitazone up-regulated LRP1 mRNA protein expression...
The apoptotic effects of shikonin (5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione) on the human colon cancer cell line SNU-407 were investigated in this study. Shikonin showed dose-dependent cytotoxic activity against cells, with an estimated IC₅₀ value 3 µM after 48 h treatment. induced apoptosis, as evidenced by body formation, sub-G₁ phase and DNA fragmentation. death activating mitogen-activated protein kinase family members, process was mediated activation...
Obesity and type 2 diabetes are major public health issues worldwide, contributing to increased cardiovascular morbidity mortality. The proportions of people with obesity and/or have recently reaching epidemic levels in Asia [1]. Although pharmacologic modality is the mainstay treatment diabetes, remedies using plants (e.g., garlic, psyllium, green tea) stimulated a new interest research [2]. Green tea (Camellia sinensis) one world's most popular beverages, especially Asian countries...
Inflammation plays an important role in coronary artery disease from the initiation of endothelial dysfunction to plaque formation final rupture plaque. In this study, we investigated potential pathophysiological and clinical relevance novel cytokines secreted various cells including adipocytes, cells, inflammatory predicting (CAD) asymptomatic subjects with type 2 diabetes mellitus.We enrolled a total 70 diabetic patients without documented history cardiovascular disease, determined serum...
Background: The atherogenic effects of hypothyroidism on lipid metabolism could result, in part, from the reduced clearance remnant lipoproteins. In this study, we investigated expression hepatic low-density lipoprotein receptor–related protein 1 (LRP1), a receptor for lipoproteins, and effect 3,3′,5-triiodo-L-thyronine (T3) treatment LRP1 expression. Methods: C57BL/6 mice were fed normal diet (control group) or low-iodine supplemented with 0.15% propylthiouracil (PTU/LI 4 weeks. Mice PTU/LI...
Type 1 diabetes is associated with more severe glycemic variability and frequent hypoglycemia than type 2 diabetes. Glycemic poor control diabetic complications. In this study, we demonstrate the clinical usefulness of serum 1,5-anhydroglucitol (1,5-AG) for assessing changes in excursion Seventeen patients were enrolled study. A continuous glucose monitoring system (CGMS) was applied twice at a 2-week interval to evaluate variability. The assays, including 1,5-AG, glycated albumin hemoglobin...
The objective of this study was to carry out a large population-based understand the factors associated with hypoglycemia-related hospitalizations among older Korean adults diabetes mellitus. This analyzed data from subset 2013 Health Insurance and Review Assessment service-Adult Patient Sample. A total 307,170 subjects, comprising 41.7% men 58.3% women, had Hypertension (80.8%) most common comorbidity, dyslipidemia (59.0%) ischemic heart disease (21.3%) were also prevalent. Approximately...