A5059134563- Metabolism, Diabetes, and Cancer
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- Acute Myeloid Leukemia Research
- Cardiac Fibrosis and Remodeling
- Muscle Physiology and Disorders
- Connexins and lens biology
- Cardiomyopathy and Myosin Studies
- Histone Deacetylase Inhibitors Research
- Advanced Glycation End Products research
- Mitochondrial Function and Pathology
- Retinal Diseases and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Diabetes and associated disorders
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
Chung-Ang University
2015-2025
Chung-Ang University Hospital
2001-2024
Seoul National University
2023
Kyungpook National University Hospital
2023
New Generation University College
2023
Bridge University
2023
Chonnam National University
2012-2019
Chonnam National University Hwasun Hospital
2018
University of Utah
2007-2017
Korea Institute of Science and Technology
2015
The receptors for IGF-I (IGF-IR) and insulin (IR) have been implicated in physiological cardiac growth, but it is unknown whether IGF-IR or IR signaling are critically required. We generated mice with cardiomyocyte-specific knockout of (CIGF1RKO) compared them receptor (CIRKO) response to 5 wk exercise swim training. Cardiac development was normal CIGF1RKO mice, the hypertrophic prevented. In contrast, despite reduced baseline heart size, CIRKO hearts preserved. Exercise increased content...
AimsDiet-induced obesity is associated with increased myocardial fatty acid (FA) utilization, insulin resistance, and cardiac dysfunction. The study was designed to test the hypothesis that impaired glucose utilization accounts for initial changes in FA metabolism.
IGF-1 receptor (IGF-1R) signaling is implicated in cardiac hypertrophy and longevity. However, the role of IGF-1R age-related remodeling only partially understood. We therefore sought to determine whether deletion cardiomyocytes might delay development aging-associated myocardial pathologies by examining 2-year-old male cardiomyocyte-specific knockout (CIGF1RKO) mice. Aging was associated with induction expression hearts. Cardiomyocytes hypertrophied age wild-type (WT) In contrast,...
Nanostructured conducting polypyrrole and poly(N-methylpyrrole) were successfully synthesized by simply adding monomers into a magnetic ionic liquid, bmim[FeCl4]. In this process, self-organized polymer nanostructures such as particles tubes formed without with field. The shape of nanoparticles at room temperature was almost spherical their size ranging around 60 nm relatively narrow distribution. conductivity pelletized 101−2 S/cm. From the N-methylpyrrole monomer, more attractive...
Pathological cardiac hypertrophy may be associated with reduced expression of glucose transporter 4 (GLUT4) in contrast to exercise-induced hypertrophy, where GLUT4 levels are increased. However, mice cardiac-specific deletion (G4H −/− ) have normal function the unstressed state. This study tested hypothesis that is required for myocardial adaptations hemodynamic demands. G4H and control littermates were subjected either a pathological model left ventricular pressure overload [transverse...
Abstract The insulin-like growth factor 1 receptor (IGF-1R) signaling in cardiomyocytes is implicated physiological hypertrophy and myocardial aging. Although fibroblasts account for a small amount of the heart, they are activated when heart damaged to promote cardiac remodeling. However, role IGF-1R still unknown. In this study, we investigated roles IGF-1 during agonist-induced fibrosis evaluated molecular mechanisms cultured fibroblasts. Using an experimental model with angiotensin...
Although increased levels of myocardial receptor activator nuclear factor (NF)-κB ligand (RANKL) have been reported in heart failure, the role this pathway mediating activation inflammatory pathways during remodelling is less well understood. This study sought to determine RANKL regulating cytokine expression. A marked increase expression occurred as early 6h following transverse aortic constriction (TAC) mouse hearts and persisted at 3 17 days. An tumour necrosis factor-α (TNF-α),...
Although thyroid-stimulating hormone (TSH) is known to be a major regulator of thyroid biosynthesis and growth, insulin-like growth factor 1 (IGF-1) required for mediating thyrocyte in concert with TSH vitro. We generated mice thyrocyte-selective ablation IGF-1 receptor (TIGF1RKO) explore the role signaling on function growth. In 5-wk-old TIGF1RKO mice, serum thyroxine (T4) concentrations were decreased by 30% 43% down-regulation monocarboxylate transporter 8 (MCT8), which involved T4...
Circular RNAs (circRNAs) are generally formed by back splicing and expressed in various cells. Vascular calcification (VC), a common complication of chronic kidney disease (CKD), is often associated with cardiovascular disease. The relationship between circRNAs VC has not yet been studied. Inorganic phosphate (Pi) was used to treat rat vascular smooth muscle cells induce VC. were identified analyzing RNA sequencing (RNA-seq) data, their expression change during validated. selected circRNAs,...
BACKGROUNDThe Committee of the Korean Diabetes Association on Epidemiology Mellitus performed a nationwide survey about current status glycemic control and diabetic complications in 2006. METHODS: The study included 5,652 patients recruited from rosters endocrinology clinics 13 tertiary hospitals Korea. Age, gender, height, weight, waist circumference blood pressure were investigated by standard method. Fasting postprandial 2 hour glucose, glycosylated hemoglobin (HbA1c), lipid profiles,...
Abstract Vascular calcification is characterized by the accumulation of hydroxyapatite crystals, which a result aberrant mineral metabolism. Although many clinical studies have reported its adverse effects on cardiovascular morbidity, molecular mechanism vascular calcification, especially involvement long noncoding RNAs (lncRNAs), not yet reported. From transcriptomic analysis, we discovered hundreds lncRNAs differentially expressed in rat smooth muscle cells (VSMCs) treated with inorganic...
Aberrant neovascularization is a leading cause of blindness in several eye diseases, including age-related macular degeneration and proliferative diabetic retinopathy. The identification key regulators pathological ocular has been subject extensive research great therapeutic interest. Here, we explored the previously unrecognized role cKIT its ligand, SCF (stem cell factor), process. Approach Results: Compared with normoxia, hypoxia, crucial driver neovascularization, caused to be highly...
One of the histopathologic hallmarks early diabetic retinopathy is loss pericytes. Evidences suggest that pericyte in vivo mediated by apoptosis. However, underlying cause apoptosis not fully understood. This study investigated influence methylglyoxal (MGO), a reactive alpha-dicarbonyl compound glucose metabolism, on apoptotic cell death bovine retinal Analysis internucleosomal DNA fragmentation ELISA showed MGO (200 to 800 microM) induced concentration-dependent manner. Intracellular oxygen...
Obesity and type 2 diabetes are major public health issues worldwide, contributing to increased cardiovascular morbidity mortality. The proportions of people with obesity and/or have recently reaching epidemic levels in Asia [1]. Although pharmacologic modality is the mainstay treatment diabetes, remedies using plants (e.g., garlic, psyllium, green tea) stimulated a new interest research [2]. Green tea (Camellia sinensis) one world's most popular beverages, especially Asian countries...