A5107171941- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Plant biochemistry and biosynthesis
- RNA Research and Splicing
- Cholesterol and Lipid Metabolism
- Histone Deacetylase Inhibitors Research
- Steroid Chemistry and Biochemistry
- Adipose Tissue and Metabolism
- Cytokine Signaling Pathways and Interactions
- Neuropeptides and Animal Physiology
- RNA Interference and Gene Delivery
- Genomics, phytochemicals, and oxidative stress
- Liver Disease and Transplantation
- Signaling Pathways in Disease
- Epigenetics and DNA Methylation
- Connective Tissue Growth Factor Research
- Ginseng Biological Effects and Applications
- Nail Diseases and Treatments
- Microbial Natural Products and Biosynthesis
- Synthesis and Reactivity of Heterocycles
- Moyamoya disease diagnosis and treatment
- Fungal Biology and Applications
- Alzheimer's disease research and treatments
Chonnam National University
2016-2025
Chonnam National University Hwasun Hospital
2018-2025
Chonnam National University Hospital
2023-2024
Korea Research Institute of Bioscience and Biotechnology
1997-2022
Yeouido St. Mary's Hospital
2022
Catholic University of Korea
2022
Koh Young Technology (South Korea)
2019
Kyungnam University
2014
Ewha Womans University
2010
University of Pavia
2003
Argonaute is the primary mediator of metazoan miRNA targeting (MT). Among currently identified >1,500 human RNA-binding proteins (RBPs), there are only a handful RBPs known to enhance MT and several others reported suppress MT, leaving global impact on elusive. In this study, we have systematically analyzed transcriptome-wide binding sites for 150 evaluated quantitative effect individual efficacy. contrast previous studies, show that most significantly affect all those MT-regulating function...
Abstract IL-6 is a major causative factor of inflammatory disease. Although and its signaling pathways are promising targets, orally available small-molecule drugs specific for have not been developed. To discover antagonists, we screened our in-house chemical library identified LMT-28, novel synthetic compound, as candidate blocker. The activity, mechanism action, direct molecular target LMT-28 were investigated. A reporter gene assay showed that suppressed activation STAT3 induced by IL-6,...
Alzheimer's disease (AD) is the most common neurodegenerative characterized by formation of amyloid beta (Aβ) or tau protein aggregates, hallmark cognitive decline. MicroRNAs (miRNAs) have emerged as critical factors in neurogenesis and synaptic functions central nervous system. Recent studies reported alterations miRNA expression patients with AD. However, miRNAs associated AD varied patient groups experimental models, suggesting need for a comparative study to identify commonly...
Heart failure is a leading cause of death and often accompanied by activation quiescent cardiac myofibroblasts, which results in fibrosis. In this study, we aimed to identify novel circular RNAs that regulate We applied transverse aortic constriction (TAC) for 1, 4, 8 weeks mice. RNA sequencing datasets were obtained from fibroblasts isolated use Langendorff apparatus then further processed selection criteria such as differential expression conservation species. CircSMAD4 was upregulated TAC...
(1) Background: MicroRNA-129 (miR-129) participates in tumor progression and chemoresistance various cancer types. In this study, the role of miR-129-3p, main mature form miR-129, chemoradiotherapy resistance head neck was evaluated. (2) Methods: RT-PCR, western blotting, cell proliferation assays, apoptosis invasion migration assays were used. (3) Results: miR-129-3p overexpression suppressed proliferation, invasion, SNU1041, SCC15, SCC25 human HNSCC lines. Additionally, it induced enhanced...
Circular RNAs (circRNAs) are generally formed by back splicing and expressed in various cells. Vascular calcification (VC), a common complication of chronic kidney disease (CKD), is often associated with cardiovascular disease. The relationship between circRNAs VC has not yet been studied. Inorganic phosphate (Pi) was used to treat rat vascular smooth muscle cells induce VC. were identified analyzing RNA sequencing (RNA-seq) data, their expression change during validated. selected circRNAs,...
Vascular calcification, the ectopic deposition of calcium in blood vessels, develops association with various metabolic diseases and atherosclerosis is an independent predictor morbidity mortality associated these diseases. Herein, we report that reduction microRNA-27a-3p (miR-27a-3p) causes increase activating transcription factor 3 (ATF3), a novel osteogenic factor, vascular smooth muscle cells. Both microRNA (miRNA) mRNA microarrays were performed rat cells, reciprocally regulated pairs...
Alzheimer’s disease (AD) stands as the most prevalent neurodegenerative disorder, characterized by a multitude of pathological manifestations, prominently marked aggregation amyloid beta. Recent investigations have revealed compelling association between excessive adiposity and glial activation, further correlating with cognitive impairments. Additionally, alterations in levels insulin-like growth factor 1 (IGF-1) been reported individuals metabolic conditions accompanied memory dysfunction....
Cardiac hypertrophy occurs in response to increased hemodynamic demand and can progress heart failure. Identifying the key regulators of this process is clinically important. Though it thought that phosphorylation histone deacetylase (HDAC) 2 plays a crucial role development pathological cardiac hypertrophy, detailed mechanism by which remains unclear. Here, we performed immunoprecipitation peptide pull-down assays characterize functional complex HDAC2. Protein phosphatase (PP) A was...
High fat diet can lead to metabolic diseases such as obesity and diabetes known be chronic inflammatory with high prevalence worldwide. Recent studies have reported cognitive dysfunction in obese patients is caused by a diet. Accordingly, called "type 3 diabetes" or "diabetic dementia". Although dysregulation of protein-coding genes has been extensively studied, profiling noncoding RNAs including long (lncRNAs) circular (circRNAs) not yet. Therefore, the objective this study was obtain...
Abstract Vascular calcification is characterized by the accumulation of hydroxyapatite crystals, which a result aberrant mineral metabolism. Although many clinical studies have reported its adverse effects on cardiovascular morbidity, molecular mechanism vascular calcification, especially involvement long noncoding RNAs (lncRNAs), not yet reported. From transcriptomic analysis, we discovered hundreds lncRNAs differentially expressed in rat smooth muscle cells (VSMCs) treated with inorganic...
Vascular calcification (VC), or calcium deposition inside the blood vessels, is common in patients with atherosclerosis, cardiovascular disease, and chronic kidney disease. Although several treatments are available to reduce calcification, incidence of VC continues rise. Recently, there have been reports describing regulation circular RNAs (circRNAs) various diseases. However, role circRNAs has not yet fully explored. Here, we investigated function circSmoc1-2, one generated from Smoc1 gene,...
Previously, we reported that phosphorylation of histone deacetylase 2 (HDAC2) and the resulting activation causes cardiac hypertrophy. Through further study specific binding partners phosphorylated HDAC2 their mechanism regulation, can better understand how hypertrophy develops. Thus, in present study, aimed to elucidate function one such partner, heat shock protein 70 (HSP70).Primary cultures rat neonatal ventricular cardiomyocytes H9c2 cardiomyoblasts were used for vitro cellular...
Although binge alcohol-induced gut leakage has been studied extensively in the context of reactive oxygen species-mediated signaling, it was recently revealed that post-transcriptional regulation plays an essential role as well. Ethanol (EtOH)-inducible cytochrome P450-2E1 (CYP2E1), a key enzyme EtOH metabolism, promotes hepatic steatosis and inflammatory liver disease, at least part by mediating changes intestinal permeability. For instance, elevated permeability to endotoxins have shown be...