A5103080178- Cancer and Skin Lesions
- Nail Diseases and Treatments
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Urticaria and Related Conditions
- Tumors and Oncological Cases
- RNA Research and Splicing
- Cutaneous lymphoproliferative disorders research
- Cell Adhesion Molecules Research
- Drug-Induced Adverse Reactions
- Nonmelanoma Skin Cancer Studies
- Autoimmune Bullous Skin Diseases
- Cytokine Signaling Pathways and Interactions
- Dermatology and Skin Diseases
- Cellular Mechanics and Interactions
- Chemotherapy-related skin toxicity
- Skin Diseases and Diabetes
- Psoriasis: Treatment and Pathogenesis
- Fungal Infections and Studies
- Histiocytic Disorders and Treatments
- Consumer Perception and Purchasing Behavior
- RNA regulation and disease
- Skin Protection and Aging
- Skin and Cellular Biology Research
- Dermatologic Treatments and Research
Seoul National University
2006-2024
Soonchunhyang University
2012-2023
Institute for Basic Science
2020-2022
The University of Texas Southwestern Medical Center
2015-2019
Johns Hopkins Medicine
2015
Johns Hopkins University
2015
Soon Chun Hyang University Cheonan Hospital
2014
Yonsei University
2010-2011
Soonchunhyang University Hospital
2010
Molecular Oncology (United States)
2005
Precise regulation of microRNA (miRNA) expression is critical for diverse physiologic and pathophysiologic processes. Nevertheless, elucidation the mechanisms through which miRNA regulated has been greatly hindered by incomplete annotation primary (pri-miRNA) transcripts. While a subset miRNAs are hosted in protein-coding genes, majority pri-miRNAs transcribed as poorly characterized noncoding RNAs that 10's to 100's kilobases length low abundance due efficient processing endoribonuclease...
Although numerous long noncoding RNAs (lncRNAs) have been identified, our understanding of their roles in mammalian physiology remains limited. Here, we investigated the physiologic function conserved lncRNA Norad vivo. Deletion mice results genomic instability and mitochondrial dysfunction, leading to a dramatic multi-system degenerative phenotype resembling premature aging. Loss tissue homeostasis Norad-deficient animals is attributable augmented activity PUMILIO proteins, which act as...
The growth of normal cells is arrested when they come in contact with each other, a process known as inhibition. Contact inhibition lost during tumorigenesis, resulting uncontrolled cell growth. Here, we investigated the role tetraspanin transmembrane 4 superfamily member 5 (TM4SF5) and tumorigenesis. We found that TM4SF5 was overexpressed human hepatocarcinoma tissue. expression clinical samples hepatocellular carcinoma lines correlated enhanced p27Kip1 cytosolic stabilization well...
Abstract Small, compact genomes confer a selective advantage to viruses, yet human cytomegalovirus (HCMV) expresses the long non-coding RNAs (lncRNAs); RNA1.2, RNA2.7, RNA4.9, and RNA5.0. Little is known about function of these lncRNAs in virus life cycle. Here, we dissected functional molecular landscape HCMV lncRNAs. We found that occupy ~ 30% 50–60% total poly(A)+viral transcriptome, respectively, throughout three abundantly expressed lncRNAs, appear be essential all infection states....
Although binge alcohol-induced gut leakage has been studied extensively in the context of reactive oxygen species-mediated signaling, it was recently revealed that post-transcriptional regulation plays an essential role as well. Ethanol (EtOH)-inducible cytochrome P450-2E1 (CYP2E1), a key enzyme EtOH metabolism, promotes hepatic steatosis and inflammatory liver disease, at least part by mediating changes intestinal permeability. For instance, elevated permeability to endotoxins have shown be...
Psoriasis is a chronic inflammatory skin disease characterized by epidermal hyperproliferation, aberrant differentiation of keratinocytes, and dysregulated immune responses. WW domain-containing oxidoreductase (WWOX) non-classical tumor suppressor gene that regulates multiple cellular processes, including proliferation, apoptosis, migration. This study aimed to explore the possible role WWOX in pathogenesis psoriasis. Immunohistochemical analysis showed expression was increased keratinocytes...
Lichen planus pigmentosus-inversus is a rare variant of lichen pigmentosus.The eruption occurs mainly in the flexural regions and presents with brownish macules patches.Here we describe case 31-year-old Korean woman who presented hyperpigmented lesions over her antecubital popliteal area groin.Physical examination revealed multiple patches on intertriginous without pruritis, histologic findings showed regressive pattern planus.These clinical histological were consistent diagnosis...
Abstract Spreading of SNU16mAd gastric carcinoma cells was previously shown to be regulated via a signaling network from transforming growth factor β1 (TGFβ1) integrins signaling, through mediation protein kinase C δ (PKCδ). However, in the previous study, roles PKCδ appeared complicated. In this study clarify spreading cells, we questioned if PKC activation phorbol 12‐myristate 13‐acetate (PMA) treatment could mimic TGFβ1 effects. An acute PMA increased phosphorylations focal adhesion (FA)...
Abstract SARS-CoV-2 is an RNA virus whose success as a pathogen relies on its ability to repurpose host RNA-binding proteins (RBPs) form own interactome. Here, we developed and applied robust ribonucleoprotein capture protocol uncover the We report 109 factors that directly bind RNAs including general antiviral such ZC3HAV1, TRIM25, PARP12. Applying RNP another coronavirus HCoV-OC43 revealed evolutionarily conserved interactions between viral proteins. Network transcriptome analyses...
Dear Editor: Here, we report the case of a 78-year-old healthy woman who presented with 7.5×8-cm erythematous eschar-like crusted indurated plaque and pustules purulent discharges on chicken-pecked scar right forearm that developed 2 month prior to her visit (Fig. 1). The patient was diagnosed type diabetes hypertension 12 years earlier. She afebrile otherwise healthy. Fig. 1 Erythematous forearm. Skin biopsy performed, including staining hematoxylin eosin, Gomori...