A5100389568- Hair Growth and Disorders
- melanin and skin pigmentation
- Dermatology and Skin Diseases
- Dermatologic Treatments and Research
- Skin Protection and Aging
- Cancer and Skin Lesions
- Acne and Rosacea Treatments and Effects
- Skin and Cellular Biology Research
- Autoimmune Bullous Skin Diseases
- RNA regulation and disease
- Cutaneous Melanoma Detection and Management
- Genetic and rare skin diseases.
- Psoriasis: Treatment and Pathogenesis
- Adipose Tissue and Metabolism
- Cutaneous lymphoproliferative disorders research
- Advancements in Transdermal Drug Delivery
- Chemotherapy-related skin toxicity
- Nail Diseases and Treatments
- Immune Response and Inflammation
- Pancreatic function and diabetes
- Hedgehog Signaling Pathway Studies
- Wnt/β-catenin signaling in development and cancer
- Pancreatic and Hepatic Oncology Research
- Wound Healing and Treatments
- Drug-Induced Adverse Reactions
Ministry of Health
2025
Sibu Hospital
2025
University of Maryland, Baltimore
2020-2024
Chungnam National University
2015-2024
Harvard University
2024
Anne Arundel Medical Center
2022-2024
Seoul Veterans Hospital
2018-2024
Brooklyn Hospital Center
2010-2023
Chungnam National University Hospital
2011-2023
University of California, San Francisco
2019-2023
We have studied mechanisms by which leptin overexpression, reduces body weight via anorexic and thermogenic actions, induces triglyceride depletion in adipocytes nonadipocytes. Here we show that alters pancreatic islets the mRNA of genes encoding enzymes free fatty acid metabolism uncoupling protein-2 (UCP-2). In animals infused with a recombinant adenovirus containing cDNA, levels mRNAs mitochondrial peroxisomal oxidation rose 2- to 3-fold, whereas an enzyme esterification declined from...
Recently, autologous platelet-rich plasma (PRP) has attracted attention in various medical fields, including plastic and orthopedic surgery dermatology, for its ability to promote wound healing. PRP been tested during facelift hair transplantation reduce swelling pain increase density.To investigate the effects of on growth using vivo vitro models.PRP was prepared double-spin method applied dermal papilla (DP) cells. The proliferative effect activated DP cells measured. To understand...
Autologous platelet-rich plasma has attracted attention in various medical fields recently, including orthopedic, plastic, and dental surgeries dermatology for its wound healing ability. Further, it been used clinically mesotherapy skin rejuvenation.In this study, the effects of activated (aPRP) platelet-poor (aPPP) have investigated on remodelling extracellular matrix, a process that requires activation dermal fibroblasts, which is essential rejuvenation aged skin.Platelet-rich (PRP) (PPP)...
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the urgent need for effective prophylactic vaccination to prevent spread of severe acute respiratory syndrome 2 (SARS-CoV-2). Intranasal is an attractive strategy COVID-19 as nasal mucosa represents first-line barrier SARS-CoV-2 entry. current intramuscular vaccines elicit systemic immunity but not necessarily high-level mucosal immunity. Here, we tested a single intranasal dose our candidate adenovirus type 5-vectored vaccine...
Hyperleptinemia causes disappearance of body fat without a rise in free fatty acids (FFA) or ketones, suggesting that leptin can deplete adipocytes releasing FFA. To test this, we measured FFA and glycerol released from obtained normal lean Zucker diabetic rats (+/+) incubated for 0, 3, 6, 24 h either 20 ng/ml recombinant 100 nm norepinephrine (NE). Whereas NE increased both release +/+ rats, parallel increase release. In obese (fa/fa) with defective receptors, release, but had no effect on...
Overaccumulation of lipids in nonadipose tissues obese rodents may lead to lipotoxic complications such as diabetes. To assess the pathogenic role lipogenic transcription factor, sterol regulatory element binding protein 1 (SREBP-1), we measured its mRNA liver and islets obese, leptin-unresponsive fa / Zucker diabetic fatty rats. Hepatic SREBP-1 was 2.4 times higher than lean +/+ controls, primarily because increased SREBP-1c expression. enzymes ranged from 2.4- 4.6-fold triacylglycerol (TG)...
Obesity is associated with both insulin resistance and hyperinsulinemia. Initially hyperinsulinemia compensates for the thereby maintains normal glucose homeostasis. also increased tissue triglyceride (TG) content. To determine whether might be secondary to TG, we studied correlations between TG content of skeletal muscle, liver, pancreas plasma insulin, [insulin] × [glucose], β-cell function in four rat models widely varying fat content: obese Zucker diabetic fatty rats, free-feeding lean...
Abstract Programmed death-1 (PD-1) and its ligand PD-L1 are checkpoint molecules which regulate immune responses. Little is known about their functions in T cell migration there contradictory data roles regulatory (Treg) function. Here we show activated Tregs CD4 effector cells (Teffs) use PD-1/PD-L1 CD80/PD-L1, respectively, to transendothelial across lymphatic endothelial (LECs). Antibody blockade of Treg PD-1, Teff CD80 (the alternative for PD-L1), or LEC impairs vitro vivo. signals...
Bonding characteristics of low-dielectric-constant (low-k) fluorine-incorporated silicon oxide (SiOF) and carbon-incorporated (SiOC) films prepared by plasma enhanced chemical vapor deposition were investigated Fourier transform infrared spectroscopy (FTIR). The frequency Si–O stretching vibration mode in SiOF film shifted to higher wave number (blueshift) with the increase fluorine incorporation, while that SiOC lower (redshift) as carbon content increased. In N2-annealed film, slightly...
The physiologic function of the progressive hyperleptinemia diet-induced obesity is unknown. However, that lipotoxicity in nonadipose tissues congenitally unleptinized obese rodents far greater than hyperleptinemic has suggested an antilipotoxic role. To test this hypothesis, mice with severe lipotoxic cardiomyopathy, induced transgenically by cardiomyocyte-specific overexpression acyl CoA synthase (ACS) gene, were made treatment recombinant adenovirus containing leptin cDNA. Normoleptinemic...
Leptin was overexpressed in the liver of normal Wistar rats by infusing recombinant adenovirus containing cDNA encoding leptin. Plasma leptin levels rose to 12-24 ng/ml (vs. <2 control rats), and food intake body weight fell. Visible fat disappeared within 7 days. insulin fell <50% association with hypoglycemia, suggesting enhanced sensitivity. Although beta-cells appeared histologically normal, pancreases were unresponsive perfusion stimulatory glucose arginine. Since islet triglyceride...
Background: Aquaporins (AQPs) are a family of water transporting proteins present in many mammalian epithelial and endothelial cell types.Among the AQPs, AQP3 is known to be water/glycerol transporter expressed human skin.Objective: The relationship between expression level transpidermal loss (TEWL) lesional peri-lesional skin psoriasis-affected patients, hydration psoriasis was investigated.Methods: healthy control determined using immunohistochemical immunofluroscence staining.TEWL were...
Highlights•Alpha toxin activates the inflammasome, preventing bacterial clearance•NLRP3 activation, not downstream cytokine production, leads to impaired defense•Macrophage NLRP3 activation sequesters mitochondria away from internalized S. aureus•Mitochondrial ROS is required for caspase-1 and killing in macrophagesSummaryClinical severity of Staphylococcus aureus respiratory infection correlates with alpha (AT) expression. AT inflammasome; deletion Nlrp3, or neutralization, protects mice...
Background Vitamin D plays an important role in the immune system, and its deficiency has been implicated various skin diseases, including atopic dermatitis psoriasis. Acne is a common inflammatory disease; however, association with vitamin remains unclear. Objectives We evaluated levels patients acne to determine effect of supplementation. Methods This study included 80 healthy controls. Serum 25-hydroxyvitamin (25(OH)D) were measured, demographic data collected. D-deficient treated oral...
4520 Background: In aBTC, GemCis is the standard of care as 1 st -line treatment. Immunotherapies have shown early promising efficacy in some BTC patients (pts). We assessed D (anti-PD-L1) ± T (anti-CTLA-4) and 1L pts, including an extensive biomarker analysis (NCT03046862). Methods: Pts were first enrolled cohort (BMC) to receive cycle Gem 1000 mg/m 2 + Cis 25 on D1 & D8, followed by 1120 mg 75 mg, Q3W until disease progression (PD). Subsequent pts allocated (3 combo [3C]) or D+T (4...
A novel and efficient method for the production of enantiomerically pure (R)-(-)-hydroxycarboxylic acids by in vivo depolymerization microbial polyester polyhydroxyalkanoates (PHAs) was developed. Using this method, several model compounds, (R)-(-)-3-hydroxyalkanoic acids, consisting 4 to 12 carbon atoms, (R)-(-)-3-hydroxy-5-phenylvaleric acid, could be prepared. In particular, (R)-(-)-3-hydroxybutyric acid efficiently prepared method. By providing environmental condition which cells possess...