A5014245166- Down syndrome and intellectual disability research
- Family and Disability Support Research
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Epilepsy research and treatment
- COVID-19 and Mental Health
- Genetics and Neurodevelopmental Disorders
- Cerebral Palsy and Movement Disorders
- Autism Spectrum Disorder Research
- Pharmacological Effects and Toxicity Studies
- Child and Adolescent Psychosocial and Emotional Development
- Digital Mental Health Interventions
- Global Public Health Policies and Epidemiology
- Mycobacterium research and diagnosis
- Ion channel regulation and function
- Immune Response and Inflammation
- Skin Protection and Aging
- Mental Health Treatment and Access
- Infant Development and Preterm Care
- Genomics and Rare Diseases
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Schizophrenia research and treatment
- Global Health and Surgery
- Immune Cell Function and Interaction
Berea College
2017-2025
University of Maryland, Baltimore
2021-2025
Galgotias University
2023
Central Institute of Medicinal and Aromatic Plants
2023
Indian Institute of Technology Delhi
2023
Indian Institute of Sugarcane Research
2022
Narayana Dental College and Hospital
2021
Narayan Medical College and Hospital
2020
Enam Medical College & Hospital
2020
Emory University
2020
Abstract Current immunosuppressants effectively suppress adaptive and innate immune responses, but their broad, antigen-non-specific effects often result in significant complications. Here, we conducted a systematic investigation of drug on gut microbiome, metabolic pathways, lymphoid architecture lymphocyte trafficking four major classes including tacrolimus, prednisone, mycophenolate mofetil (MMF), Fingolimod (FTY). We show that induced progressive alterations the microbiome where initial...
Abstract Programmed death-1 (PD-1) and its ligand PD-L1 are checkpoint molecules which regulate immune responses. Little is known about their functions in T cell migration there contradictory data roles regulatory (Treg) function. Here we show activated Tregs CD4 effector cells (Teffs) use PD-1/PD-L1 CD80/PD-L1, respectively, to transendothelial across lymphatic endothelial (LECs). Antibody blockade of Treg PD-1, Teff CD80 (the alternative for PD-L1), or LEC impairs vitro vivo. signals...
To evaluate sodium channel genes as candidates for epilepsy susceptibility and their role in therapeutic efficacy, we screened coding single-nucleotide polymorphism of SCN1A p. Thr 1067 Ala or c.3184 A-->G (rs2298771) SCN2A p.Arg19Lys c.56 G-->A (rs17183814) north Indian patients.The genotyping was performed 160 control subjects 336 patients with epilepsy, whom 117 were drug resistant 219 responsive. Therapeutic monitoring phenytoin, carbamazepine, phenobarbital valproate also 20% the to...
Abstract The beneficial effects attributed to Bifidobacterium are largely their immunomodulatory capabilities, which likely be species- and even strain-specific. However, strain-specificity in direct indirect immune modulation remain uncharacterized. We have shown that B. pseudolongum UMB-MBP-01, a murine isolate strain, is capable of suppressing inflammation reducing fibrosis vivo. To ascertain the mechanism driving this activity determine if it specific we compared porcine tropic strain...
In epilepsy, in spite of the best possible medications and treatment protocols, approximately one-third patients do not respond adequately to anti-epileptic drugs. Such interindividual variations drug response are believed result from genetic candidate genes belonging multiple pathways.In present pharmacogenetic analysis, a total 402 epilepsy were enrolled. Of them, 128 diagnosed as drug-resistant 274 having drug-responsive epilepsy. We selected 10 gene polymorphisms three major classes,...
Background . The coexistence of psychiatric disorders in people with intellectual disability (ID) is common. This study determined the prevalence children ID Barwani, India. Method A total 262 were evaluated for using diagnostic criteria outlined International Classification Diseases (ICD-10). Results Psychiatric appeared participants at following rates: attention deficit hyperactivity disorder (ADHD), 6.5%; autism, 4.2%; anxiety, 2.7%; bipolar disorder, 1.1%; delusional 0.8%; depression,...
Intellectual disability (ID) is a global public health concern. Prevalence of ID and its association with age other demographic factors required for planning purposes in India.This study analyzed the age-adjusted prevalence rural urban populations correlation children adults.Disability data published report (2002) National Sample Survey Organization were analyzed, using Z-test to measure differences prevalence. Spearman rho was calculated determine strength direction association, regression...
Regulatory T cell (Treg) lymphatic migration is required for resolving inflammation and prolonging allograft survival. Focusing on Treg interactions with endothelial cells (LECs), we dissect mechanisms functional consequences of transendothelial (TEM). Using three genetic mouse models pancreatic islet transplantation, show that lymphotoxin (LT) αβ LEC LTβ receptor (LTβR) signaling are efficient suppressive function to prolong Inhibition LT increases conversion Foxp3loCD25lo exTregs. In a...
Abstract In epilepsy, there is a tendency towards recurrent unprovoked seizures. Seizures result due to the excessive electrical misfiring in brain between neurons and disturbance neurotransmitter release. Several gene products affect behavior of these by regulating neurotransmission via several mechanisms. One such gene, Synapsin‐2 ( SYN2) , involved synaptogenesis also reported regulate We hypothesized that SYN2 its polymorphisms could process epileptogenesis therapeutic response humans....
The Indian population suffers with significant burden of mental illness. prevalence rate and its association age other demographic indicators are needed for planning purpose.This study attempted to calculate age-wise illness rural urban settings, age.Data published in National Sample Survey Organization (2002) report on disability is used the analysis. Spearman correlation strength association, z-test difference prevalence, regression statistics predicting used.Overall have 14.9/1000 It...
Abstract Intrinsic metabolism shapes the immune environment associated with suppression and tolerance in settings such as organ transplantation cancer. However, little is known about metabolic activities an immunosuppressive environment. In this study, we employed metagenomic, metabolomic, immunological approaches to profile early effects of immunosuppressant drug tacrolimus, antibiotics, or both gut lumen circulation using a murine model. Tacrolimus induced rapid profound alterations within...
Background. Despite ongoing improvements to regimens preventing allograft rejection, most cardiac and other organ grafts eventually succumb chronic vasculopathy, interstitial fibrosis, or endothelial changes, graft failure. The events leading rejection are still poorly understood the gut microbiota is a known driving force in immune dysfunction. We previously showed that dysbiosis profoundly influences outcome of vascularized allografts subsequently identified biomarker species associated...
Background: Management of behavioral problems in children with intellectual disabilities (ID) is a great concern resource-poor areas India. This study attempted to analyze the efficacy intervention provided settings. Objective: was aimed examine outcome management ID poor rural region Materials and Methods: We analyzed data from 104 between 3 18 years old who received interventions for clinical or community setting. The assessment scale Indian mental retardation (BASIC-MR) used quantify...
The longevity of people with intellectual disabilities is increasing in developing nations. However, nations lack a proper system care for aging persons disabilities. Until now the has been provided by parents and relatives home environment countries, but this scenario also changing; therefore, there strong need to explore plan population which feasible replicable. National Trust an autonomous body Government India developed comprehensive adults In article, discussed using socioecological...