A5048492117- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Omental and Epiploic Conditions
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Intraperitoneal and Appendiceal Malignancies
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Cancer Immunotherapy and Biomarkers
- Asthma and respiratory diseases
- COVID-19 Clinical Research Studies
- Neonatal Respiratory Health Research
- Antifungal resistance and susceptibility
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- Eosinophilic Esophagitis
- Fungal Infections and Studies
- Monoclonal and Polyclonal Antibodies Research
- Genetic factors in colorectal cancer
- History of Education in Spain
- Influenza Virus Research Studies
- Immunodeficiency and Autoimmune Disorders
- CAR-T cell therapy research
University of Alabama at Birmingham
2015-2024
Instituto Politécnico Nacional
2007-2015
Center for Research and Advanced Studies of the National Polytechnic Institute
2009-2015
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the urgent need for effective prophylactic vaccination to prevent spread of severe acute respiratory syndrome 2 (SARS-CoV-2). Intranasal is an attractive strategy COVID-19 as nasal mucosa represents first-line barrier SARS-CoV-2 entry. current intramuscular vaccines elicit systemic immunity but not necessarily high-level mucosal immunity. Here, we tested a single intranasal dose our candidate adenovirus type 5-vectored vaccine...
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the urgent need for effective preventive vaccination to reduce burden and spread of severe acute respiratory syndrome (SARS) 2 (SARS-CoV-2) in humans. Intranasal is an attractive strategy prevent COVID-19 as nasal mucosa represents first-line barrier SARS-CoV-2 entry before viral lung. Although vaccine development rapidly progressing, current intramuscular vaccines are designed elicit systemic immunity without conferring...
Intestinal cDC1 drive the generation of FoxP3 + CD8 T regs to maintain tolerance epithelial-derived self-antigen.
Multiple mechanisms restrain inflammation in neonates, most likely to prevent tissue damage caused by overly robust immune responses against newly encountered pathogens. Here, we identify a population of pulmonary dendritic cells (DCs) that express intermediate levels CD103 (CD103
The coronavirus disease 2019 (COVID-19) pandemic has illustrated the critical need for effective prophylactic vaccination to prevent spread of severe acute respiratory syndrome 2 (SARS-CoV-2). Intranasal is an attractive approach preventing COVID-19 as nasal mucosa site initial SARS-CoV-2 entry and viral replication prior aspiration into lungs. We previously demonstrated that a single intranasal administration candidate adenovirus type 5-vectored vaccine encoding receptor-binding domain...
Lymph nodes (LNs) have evolved to maximize antigen (Ag) collection and presentation as well lymphocyte proliferation differentiation-processes that are spatially regulated by stromal cell subsets, including fibroblastic reticular cells (FRCs) follicular dendritic (FDCs). Here, we showed naïve neonatal mice poorly organized LNs with few B T undetectable FDCs, whereas adult numerous large FDC networks. Interestingly, immunization on the day of birth accelerated accumulation recruitment into...
Variability in the developing antibody repertoire is focused on third complementarity determining region of H chain (CDR-H3), which lies at center antigen binding site where it often plays a decisive role binding. The power VDJ recombination and N nucleotide addition has led to common conception that sequence CDR-H3 unrestricted its variability random composition. Under this view, immune response solely controlled by somatic positive negative clonal selection mechanisms act individual B...
Tumors that metastasize in the peritoneal cavity typically end up omental adipose tissue, a particularly immune-suppressive environment includes specialized adipose-resident regulatory T cells (Treg). Tregs rapidly accumulate omentum after tumor implantation and potently suppress antitumor immunity. However, it is unclear whether these are recruited from circulation or derived preexisting by clonal expansion. Here we show tumor-bearing omenta predominantly have thymus-derived...
Airways infection with Mycobacterium tuberculosis (Mtb) is contained mostly by T cell responses, however, Mtb has developed evasion mechanisms which affect antigen presenting (APC) maturation/recruitment delaying the onset of Ag-specific responses. Hypothetically, bypassing natural routes delivering antigens directly to APCs may overcome pathogen’s naturally evolved mechanisms, thus facilitating induction protective immune We generated a murine monoclonal fusion antibody (α-DEC-ESAT) deliver...
Inducible Bronchus Associated Lymphoid Tissue (iBALT) is an ectopic lymphoid tissue that develops in the early postnatal period and associated with severe forms of chronic lung diseases, including obstructive pulmonary disease, rheumatoid hypersensitivity pneumonitis asthma, suggesting iBALT may exacerbate these clinical conditions by promoting larger or faster immune responses lung. However, despite link between pathology formation, role pathogenesis remains unknown. Here we tested whether...
Cytotoxic cellular responses are crucial for clearing intracellular pathogens and generating host resistance. Experimental pulmonary tuberculosis is associated with an early delay in T cell elevated lung bacterial burden during chronic infection. In this study we quantified the vivo cytotoxicity mycobacterial from two pertinent tissues groups of mice infected each a strain different virulence. None strains induced cytotoxic (day 14) Interestingly, at 21 60 days post-infection, Mycobacterium...
To ascertain the in vivo role of mycobacterial lipids phthiocerol dimycocerosates (PDIM) experimental murine tuberculosis (Tb), airways infection was used to compare parental virulent clinical isolate MT103 with its mutant fadD26, lacking PDIM. Lungs were assessed as Tb-target organ and mediastinal lymph nodes corresponding lymphoid tissue, order quantify: major T-cell subsets (CD4+/CD8+/gammadelta+) their activation kinetics, bacillary burden, cytotoxicity against inoculated target cells...
Actinic Prurigo (AP) is a chronic pruritic dermatosis of unknown cause affecting sun exposed skin in defined ethnic groups with characteristic MHC alleles. However, the cutaneous dendritic cells have not been assessed.To assess situ epidermal Langerhans Cell (LC) status Prurigo.Fresh samples from three AP patients were used to evaluate LC, comparing lesional and non-lesional sites each subject.AP attending Dermatology Department at Hospital M. Gea-Gonzalez Mexico city.Lesional taken subject...