A5049368373- Omental and Epiploic Conditions
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- History of Education in Spain
- Mathematical Biology Tumor Growth
- Intraperitoneal and Appendiceal Malignancies
- IL-33, ST2, and ILC Pathways
- Amoebic Infections and Treatments
- CAR-T cell therapy research
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- Endometriosis Research and Treatment
- Eosinophilic Esophagitis
Agency for Science, Technology and Research
2025
University of Alabama at Birmingham
2022-2024
Multiple mechanisms restrain inflammation in neonates, most likely to prevent tissue damage caused by overly robust immune responses against newly encountered pathogens. Here, we identify a population of pulmonary dendritic cells (DCs) that express intermediate levels CD103 (CD103
ABSTRACT Neoadjuvant immunotherapy seeks to harness the primary tumor as a source of relevant antigens enhance systemic anti-tumor immunity through improved immunological surveillance. Despite having revolutionized treatment patients with high-risk early-stage triple-negative breast cancer (TNBC), significant portion remain unresponsive and succumb metastatic recurrence post-treatment. Here, we found that optimally scheduled neoadjuvant administration anti-4-1BB monotherapy was able...
Tumors that metastasize in the peritoneal cavity typically end up omental adipose tissue, a particularly immune-suppressive environment includes specialized adipose-resident regulatory T cells (Treg). Tregs rapidly accumulate omentum after tumor implantation and potently suppress antitumor immunity. However, it is unclear whether these are recruited from circulation or derived preexisting by clonal expansion. Here we show tumor-bearing omenta predominantly have thymus-derived...
<div>Abstract<p>Tumors that metastasize in the peritoneal cavity typically end up omental adipose tissue, a particularly immune-suppressive environment includes specialized adipose-resident regulatory T cells (Treg). Tregs rapidly accumulate omentum after tumor implantation and potently suppress antitumor immunity. However, it is unclear whether these are recruited from circulation or derived preexisting by clonal expansion. Here we show tumor-bearing omenta predominantly have...
Supplementary Data from Circulating Tregs Accumulate in Omental Tumors and Acquire Adipose-Resident Features
<div>Abstract<p>Tumors that metastasize in the peritoneal cavity typically end up omental adipose tissue, a particularly immune-suppressive environment includes specialized adipose-resident regulatory T cells (Treg). Tregs rapidly accumulate omentum after tumor implantation and potently suppress antitumor immunity. However, it is unclear whether these are recruited from circulation or derived preexisting by clonal expansion. Here we show tumor-bearing omenta predominantly have...
Supplementary Data from Circulating Tregs Accumulate in Omental Tumors and Acquire Adipose-Resident Features
Abstract The omentum, a visceral adipose tissue, is frequent site of metastasis for gastric and ovarian cancers. Advanced cancer almost always metastasizes to the omentum. Currently available therapies do not control tumor growth long-term there recurrence metastasis. In mice, cells injected intraperitoneally implant in omentum grow progressively despite tumor-specific CD8 T cells. lack effective immunity due part, rapid Treg recruitment which provides an immunosuppressive environment...