A5000051455- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Influenza Virus Research Studies
- IL-33, ST2, and ILC Pathways
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Asthma and respiratory diseases
- Histone Deacetylase Inhibitors Research
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Epigenetics and DNA Methylation
- Tuberculosis Research and Epidemiology
- Calcium signaling and nucleotide metabolism
- SARS-CoV-2 and COVID-19 Research
- Ion Channels and Receptors
- CAR-T cell therapy research
- Immunodeficiency and Autoimmune Disorders
- Wnt/β-catenin signaling in development and cancer
- Adenosine and Purinergic Signaling
- Omental and Epiploic Conditions
- Ovarian cancer diagnosis and treatment
- Eosinophilic Esophagitis
- Hematopoietic Stem Cell Transplantation
University of Alabama at Birmingham
2016-2025
Center for Rheumatology
2013-2025
Newcastle University
2024
St. Vincent's Birmingham
2023
O'Neal Comprehensive Cancer Center
2021
Emory University
2018
University of Rochester Medical Center
2009-2016
Trudeau Institute
2002-2015
Randall University
2015
University of Rochester
2008-2012
A diverse T cell repertoire is essential for a vigorous immune response to new infections, and decreasing diversity has been implicated in the age-associated decline CD8 immunity. In this study, using well-characterized mouse influenza virus model, we show that although comparable numbers of cells are elicited lung airways young aged mice after de novo infection, majority exhibit profound shifts epitope immunodominance restricted TCR responding cells. preferential reactivity viral epitopes...
Bronchus-associated lymphoid tissue (BALT) was originally described as a mucosal organ in the lungs of some species. However, while naive mice and humans typically lack BALT, pulmonary infection leads to development inducible BALT (iBALT), which is located peribronchial, perivascular, interstitial areas throughout lung. Here we investigated whether iBALT forms patients with variety lung diseases. We show that can be found suffering from multiple diseases, well-developed most prevalent...
Current influenza vaccines elicit Abs to the hemagglutinin and neuraminidase envelope proteins. Due antigenic drift, these must be reformulated annually include proteins predicted dominate in following season. By contrast, vaccination with conserved nucleoprotein (NP) elicits immunity against multiple serotypes (heterosubtypic immunity). NP is generally thought convey protection primarily via CD8 effector mechanisms. However, significant titers of anti-NP are also induced, yet involvement...
One third of the world's population is infected with Mycobacterium tuberculosis (Mtb). Although most people remain asymptomatic, they have a 10% lifetime risk developing active (TB). Thus, current challenge to identify immune parameters that distinguish individuals latent TB from those TB. Using human and experimental models Mtb infection, we demonstrated organized ectopic lymphoid structures containing CXCR5+ T cells were present in Mtb-infected lungs. In addition, found infection models,...
Significance Ectopic clusters of immune cells that mimic the structure and function secondary lymphoid organs are defined as tertiary (TLOs). They have been observed at sites chronic inflammation for decades, but their formation remained enigmatic. TLOs thought to contribute disease pathogenesis by promoting autoreactive lymphocyte survival autoantibody production. In this study we identify a novel role cytokine IL-22 in TLO development biology. We provide evidence expression within is...
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the urgent need for effective prophylactic vaccination to prevent spread of severe acute respiratory syndrome 2 (SARS-CoV-2). Intranasal is an attractive strategy COVID-19 as nasal mucosa represents first-line barrier SARS-CoV-2 entry. current intramuscular vaccines elicit systemic immunity but not necessarily high-level mucosal immunity. Here, we tested a single intranasal dose our candidate adenovirus type 5-vectored vaccine...
Intranasal vaccination should block SARS-CoV-2 transmission at the source
With increasing age, the ability to produce protective antibodies in response immunization declines, leading a reduced efficacy of vaccination elderly. To examine effect age on cognate function CD4 T cells, we have used novel adoptive transfer model that allows us compare identical numbers antigen-specific naive cells from young and aged TCR transgenic (Tg) donors. Upon donor hosts, there was significantly expansion germinal center (GC) differentiation B cell population after immunization....