Luisa Klotz
A5015273008- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Peripheral Neuropathies and Disorders
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Polyomavirus and related diseases
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Sphingolipid Metabolism and Signaling
- Peroxisome Proliferator-Activated Receptors
- Immune cells in cancer
- Acute Lymphoblastic Leukemia research
- Immunodeficiency and Autoimmune Disorders
- Mycobacterium research and diagnosis
- Chronic Lymphocytic Leukemia Research
- Nuclear Receptors and Signaling
- Barrier Structure and Function Studies
- Long-Term Effects of COVID-19
- Cytokine Signaling Pathways and Interactions
- Childhood Cancer Survivors' Quality of Life
- IL-33, ST2, and ILC Pathways
- Cell Adhesion Molecules Research
University Hospital Münster
2016-2025
University of Münster
2016-2025
Max Delbrück Center
2022-2024
Charité - Universitätsmedizin Berlin
2021-2024
Heinrich Heine University Düsseldorf
2015-2024
Humboldt State University
2019-2024
Korea National Institute of Health
2024
Hudson Institute
2024
John Wiley & Sons (United States)
2024
Ruhr University Bochum
2018-2023
There is emerging evidence that the commensal microbiota has a role in pathogenesis of multiple sclerosis (MS), putative autoimmune disease CNS. Here, we compared gut microbial composition 34 monozygotic twin pairs discordant for MS. While there were no major differences overall profiles, found significant increase some taxa such as Akkermansia untreated MS twins. Furthermore, most notably, when transplanted to transgenic mouse model spontaneous brain autoimmunity, twin-derived induced...
T helper cells secreting interleukin (IL)-17 (Th17 cells) play a crucial role in autoimmune diseases like multiple sclerosis (MS). Th17 differentiation, which is induced by combination of transforming growth factor (TGF)-β/IL-6 or IL-21, requires expression the transcription retinoic acid receptor–related orphan receptor γt (RORγt). We identify nuclear peroxisome proliferator–activated γ (PPARγ) as key negative regulator human and mouse differentiation. PPARγ activation CD4+ selectively...
To analyze whether 1 of the 2 apheresis techniques, therapeutic plasma exchange (PE) or immunoadsorption (IA), is superior in treating neuromyelitis optica spectrum disorder (NMOSD) attacks and to identify predictive factors for complete remission (CR).This retrospective cohort study was based on registry German Neuromyelitis Optica Study Group, a nationwide network established 2008. It recruited patients with diagnosed according 2006 Wingerchuk criteria aquaporin-4...
Significance The importance of natural killer (NK) cells in the control autoimmunity has recently attracted considerable attention. current study revealed NK as additional players controlling T-cell activity CNS autoimmunity. NK-mediated multiple sclerosis (MS) is dysregulated and caused by impaired DNAX accessory molecule-1/CD155 interaction between CD4 + T cells. Therapeutic immune modulation IL-2 receptor with daclizumab, which just successfully passed a phase III relapsing-remitting MS,...
Multiple sclerosis (MS) is a chronic immune-mediated demyelinating disease of the CNS. Highlighted by success B-cell-depleting therapies such as monoclonal anti-CD20 antibodies rituximab, ocrelizumab, and ofatumumab, B cells have been shown to play central role in immunopathology disease. Yet, target antigens pathogenic B-cell response MS remain unclear. We combined polyclonal stimulation peripheral blood mononuclear with human proteome-wide protein microarray identify comparing samples from...
Although glucocorticoids (GC) represent the most frequently used immunosuppressive drugs, their effects are still not well understood. In our previous studies, we have shown that treatment of monocytes with GC does cause a global suppression monocytic effector functions, but rather induces differentiation specific anti-inflammatory phenotype. The role peroxisome proliferator-activated receptor (PPAR)-γ has been extensively studied during recent years. However, relationship between and PPAR-γ...
To evaluate the effect of dimethyl fumarate (DMF; Tecfidera, Biogen, Weston, MA) on CD4(+) and CD8(+) T cell subsets in patients with multiple sclerosis (MS).Peripheral lymphocyte subsets, including memory cells helper (TH) TH1, TH2, TH17, peripheral regulatory (pTreg) subpopulations were analyzed before 6 months after onset DMF treatment.CD4(+) preferentially decreased compared to naive populations. Within population, frequencies TH1 decreased, whereas those TH2 increased TH17 remained...
Abstract Background New-generation cell-based assays have demonstrated a robust association of serum autoantibodies to full-length human myelin oligodendrocyte glycoprotein (MOG-IgG) with (mostly recurrent) optic neuritis, myelitis, and brainstem encephalitis, as well neuromyelitis optica (NMO)-like or acute-disseminated encephalomyelitis (ADEM)-like presentations. However, only limited data are yet available on cerebrospinal fluid (CSF) findings in MOG-IgG-associated (MOG-EM; also termed...
To assess outcomes for patients treated with interferon beta-1b immediately after clinically isolated syndrome (CIS) or a short delay.Participants in BENEFIT (Betaferon/Betaseron Newly Emerging MS Initial Treatment) were randomly assigned to receive (early treatment) placebo (delayed treatment). After conversion definite multiple sclerosis (CDMS) 2 years, on could switch another treatment. Eleven years randomization, reassessed.Two hundred seventy-eight (59.4%) of the original 468 (71.3%...
Aberrant immune responses represent the underlying cause of central nervous system (CNS) autoimmunity, including multiple sclerosis (MS). Recent evidence implicated crosstalk between coagulation and immunity in CNS autoimmunity. Here we identify factor XII (FXII), initiator intrinsic cascade kallikrein-kinin system, as a specific cell modulator. High levels FXII activity are present plasma MS patients during relapse. Deficiency or pharmacologic blockade renders mice less susceptible to...
Abstract Neuroinflammation is often associated with blood-brain-barrier dysfunction, which contributes to neurological tissue damage. Here, we reveal the pathophysiology of Susac syndrome (SuS), an enigmatic neuroinflammatory disease central nervous system (CNS) endotheliopathy. By investigating immune cells from blood, cerebrospinal fluid, and CNS SuS patients, demonstrate oligoclonal expansion terminally differentiated activated cytotoxic CD8 + T (CTLs). Neuropathological data derived both...
Inhibition of a mitochondrial enzyme during multiple sclerosis treatment modulates antigen-specific T cell responses in an affinity-dependent fashion.
Significance The role of metabolic processes during T cell activation has been increasingly acknowledged, and recent data suggest an impact immunometabolism on function cell-mediated autoimmunity. factors regulating in cells are not clear, however. We identify the nuclear receptor Nur77 as central regulator immunometabolism, controlling oxidative phosphorylation aerobic glycolysis activation. Functionally, restricts murine human proliferation limits inflammation autoimmune conditions animal...
BackgroundWe aim to evaluate serum neurofilament light chain (sNfL), indicating neuroaxonal damage, as a biomarker at diagnosis in large cohort of early multiple sclerosis (MS) patients.MethodsIn multicentre prospective longitudinal observational cohort, patients with newly diagnosed relapsing-remitting MS (RRMS) or clinically isolated syndrome (CIS) were recruited between August 2010 and November 2015 22 centers. Clinical parameters, MRI, sNfL levels (measured by single molecule array)...
Background: The Association of British Neurologists (ABN) 2015 guidelines suggested classifying multiple sclerosis therapies according to their average relapse reduction. We sought classify newer (cladribine, ocrelizumab, ofatumumab, ozanimod) based on these guidelines. Materials & methods: Therapies were classified by using direct comparative trial results as per ABN and generating classification probabilities for each therapy comparisons versus placebo in a network meta-analysis...