A5018712941- Multiple Sclerosis Research Studies
- Long-Term Effects of COVID-19
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- COVID-19 and Mental Health
- Infectious Encephalopathies and Encephalitis
- COVID-19 Clinical Research Studies
- Radiation Dose and Imaging
- Kawasaki Disease and Coronary Complications
- Ultrasound in Clinical Applications
- Autoimmune Neurological Disorders and Treatments
- Ultrasound and Hyperthermia Applications
- Mitochondrial Function and Pathology
- Bacterial Infections and Vaccines
- Traumatic Brain Injury and Neurovascular Disturbances
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Retinal and Optic Conditions
- Autoimmune and Inflammatory Disorders Research
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Acute Lymphoblastic Leukemia research
- Herpesvirus Infections and Treatments
- Pediatric Pain Management Techniques
- Thyroid Disorders and Treatments
Sanofi (United States)
2025
Columbia University Irving Medical Center
2015-2024
Barro Colorado Island
2024
RELX Group (United States)
2023
Columbia University
2016-2023
NewYork–Presbyterian Hospital
2012-2022
Centers for Disease Control and Prevention
2022
New York Hospital Queens
2012-2022
Multiple Sclerosis Center of Atlanta
2022
Texas Health Dallas
2021
The radiologically isolated syndrome (RIS) represents the earliest detectable pre-clinical phase of multiple sclerosis (MS). This study evaluated impact therapeutic intervention in preventing first symptom manifestation at this stage disease spectrum.We conducted a multi-center, randomized, double-blinded, placebo-controlled involving people with RIS. Individuals without clinical symptoms typical MS but incidental brain MRI anomalies consistent central nervous system (CNS) demyelination were...
Throughout the course of multiple sclerosis, gradually progressive neurologic impairment can occur, which has been called disability accrual. Current disease-modifying therapies for sclerosis have limited effects on accrual unrelated to relapses, is thought be partially caused by chronic, nonresolving neuroinflammation within central nervous system. Tolebrutinib an oral, brain-penetrant Bruton's tyrosine kinase inhibitor that targets myeloid cells (including microglia) and B in both...
Investigating the potential of myelin repair strategies in multiple sclerosis (MS) requires an understanding dynamics during lesion evolution. The objective this study is to longitudinally measure water fraction (MWF), MRI biomarker myelin, new MS lesions and identify factors that influence their subsequent content. Twenty-three patients were scanned with whole-brain Fast Acquisition Spiral Trajectory T2prep (FAST-T2) MWF mapping at baseline median follow-up 6 months. Eleven healthy controls...
Importance Neurological manifestations during acute SARS-CoV-2–related multisystem inflammatory syndrome in children (MIS-C) are common hospitalized patients younger than 18 years and may increase risk of new neurocognitive or functional morbidity. Objective To assess the association severe neurological a hospital admission with morbidities at discharge. Design, Setting, Participants This prospective cohort study from 46 centers 10 countries included who were for SARS-CoV-2 MIS-C between...
Background Steps towards the development of diagnostic criteria are needed for children with radiologically isolated syndrome to identify at risk clinical demyelination. Objectives To evaluate 2005 and 2016 MAGNIMS magnetic resonance imaging dissemination in space multiple sclerosis, both alone oligoclonal bands cerebrospinal fluid added, as predictors a first event consistent central nervous system demyelination syndrome. Methods We analysed an international historical cohort 61 (≤18...
The development of accurate prognoses in multiple sclerosis is difficult, as the disease characterized by heterogeneous patterns brain abnormalities that relate an unclear way to future impairments. Here, we use a statistical modeling approach determine if baseline pattern connectome disruption due T2-FLAIR lesions could predict patient's processing speed, measured using Symbol Digits Modality Test scores. Imaging data, demographics and scores were collected from 61 early relapsing remitting...
<h3>BACKGROUND AND PURPOSE:</h3> Quantitative assessment of clinical and pathologic consequences white matter abnormalities in multiple sclerosis is critical understanding the pathways disease. This study aimed to test whether gray atrophy was related connecting identify patterns imaging biomarker that were patient processing speed. <h3>MATERIALS METHODS:</h3> Image data Symbol Digit Modalities Test scores collected from a cohort patients with early sclerosis. The Network Modification Tool...
<strong>Background:</strong> Ataxia with vitamin E deficiency (AVED) is an autosomal recessive disorder that usually presents ataxia, areflexia, and proprioceptive vibratory sensory loss. Dystonia has been reported rarely. <strong>Case Report:</strong> An 11-year-old female presented dystonic head tremor cervical bilateral arm dystonia. Her 14-year-old older brother had generalized One year later, the developed dysarthria, limb dysmetria, gait ataxia. Compound heterozygous mutations in...
Abstract Objective To report initial results of a planned multicenter year‐long prospective study examining the risk and impact COVID‐19 among persons with neuroinflammatory disorders (NID), particularly multiple sclerosis (MS). Methods In April 2020, we deployed online questionnaires to individuals in their home environment assess prevalence potential factors suspected NID (PwNID) change neurological care. Results Our cohort included 1115 participants (630 NID, 98% MS; 485 reference) as 30...
Fingolimod is an oral medication approved for the treatment of relapsing multiple sclerosis (MS). It unique compared with other disease-modifying therapies MS in that it first agent and has a novel mechanism action. In clinical trials postmarket use, demonstrates clear therapeutic efficacy. However, associated certain risks including cardiac concerns. The recent reports events potentially drug prompted regulatory agencies review use fingolimod USA Europe. After completion their review, US...
<h3>Objective</h3> To test the association between physical function and social environment in multiple sclerosis (MS), we quantified personal networks. <h3>Methods</h3> In this cross-sectional study, analyzed data from 2 academic MS centers, with center 1 serving as a discovery group extension group. We performed meta-analysis of centers to extend analysis. used responses questionnaire map structure health habits participants9 networks well NIH Patient-Reported Outcomes Measurement...