A5014685203- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- COVID-19 Clinical Research Studies
- Anesthesia and Neurotoxicity Research
- Family and Patient Care in Intensive Care Units
- Respiratory Support and Mechanisms
- Kawasaki Disease and Coronary Complications
- Infectious Encephalopathies and Encephalitis
- Sepsis Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Infant Development and Preterm Care
- Thermal Regulation in Medicine
- Optical Imaging and Spectroscopy Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Innovative Teaching Methods
- Innovations in Medical Education
- Nosocomial Infections in ICU
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Non-Invasive Vital Sign Monitoring
- E-Learning and COVID-19
- Bioinformatics and Genomic Networks
- Opioid Use Disorder Treatment
Columbia University
2017-2025
Columbia College
2024
Royal College of Physicians
2024
Chungnam National University
2024
Morgan Stanley Children's Hospital
2017-2024
Columbia University Irving Medical Center
2018-2024
Children's Hospital of Philadelphia
2018-2022
Centers for Disease Control and Prevention
2022
NewYork–Presbyterian Hospital
2007-2022
New York Hospital Queens
2007-2022
The disease caused by severe acute respiratory syndrome coronavirus 2, known as 2019, has resulted in a global pandemic. Reports are emerging of new hyperinflammatory related to 2019 children and adolescents. Centers for Disease Control Prevention designated this multisystem inflammatory children. Our objective was develop clinical inpatient protocol the evaluation, management, follow-up patients with syndrome.
Summary Purpose: Optical recording of intrinsic signals provides the highest combined spatial and temporal resolution with broad sampling for measuring cerebral blood volume (CBV) hemoglobin oxygenation in cortex. Few opportunities arise to apply this laboratory method record spontaneous seizures unanesthetized human brain during neurosurgery. We report such a rare opportunity man recurrent focal epilepsy arising from cavernous malformation. Methods: recorded optical (IOS) cortex...
Importance Neurological manifestations during acute SARS-CoV-2–related multisystem inflammatory syndrome in children (MIS-C) are common hospitalized patients younger than 18 years and may increase risk of new neurocognitive or functional morbidity. Objective To assess the association severe neurological a hospital admission with morbidities at discharge. Design, Setting, Participants This prospective cohort study from 46 centers 10 countries included who were for SARS-CoV-2 MIS-C between...
Interictal spikes (IISs) represent burst firing of a small focal population hypersynchronous, hyperexcitable cells. Whether cerebral blood flow (CBF) is adequate to meet the metabolic demands this dramatic increase in membrane excitability unknown. Positron emission tomography, single photon computed and functional magnetic resonance imaging studies have shown increases CBF hypometabolism, thus indicating likelihood perfusion. We measured tissue oxygenation rat model IIS using oxygen...
BACKGROUND AND OBJECTIVES Multisystem inflammatory syndrome in children (MIS-C) is a severe hyperinflammatory illness occurring after acute respiratory coronavirus 2 infection. The optimal treatment of MIS-C unknown, although prior studies have indicated benefits intravenous immunoglobulin (IVIG) and glucocorticoids. We hypothesize that early with glucocorticoids associated shorter hospital length stay (LOS). METHODS This study multicenter retrospective cohort patients hospitalized over...
The spatiotemporal dynamics of neurovascular coupling during epilepsy are not well understood, and there little data from studies the human brain. We investigated changes in total hemoglobin (Hbt) oxygenation patients undergoing surgery with intraoperative intrinsic optical spectroscopy (IOS) triggered afterdischarges (ADs). found an early (approximately 0.5 secs) focal dip oxygenation, arising precisely stimulated gyrus that lasted for 11.5+/-10.0 secs, approximately length AD (10.4+/-4.4...
To evaluate neurodevelopmental and mental disorders after PICU hospitalization in children requiring invasive mechanical ventilation for severe respiratory illness.Retrospective longitudinal observational cohort.Texas Medicaid Analytic eXtract data from 1999 to 2012.Texas Medicaid-enrolled greater than or equal 28 days old less 18 years hospitalized a primary illness, without major chronic conditions predictive of abnormal neurodevelopment.We examined rates International Classification...
Debriefing after pediatric rapid response team activations (RRT-As) in a tertiary care children's hospital was identified to occur only sporadically. The lack of routine debriefing RRT-As as missed learning opportunity.We implemented formal program and assessed staff attitudes toward experiences with RRT-As.Real-time feedback for pediatrics residents captured clinical data each RRT-A from July 2014 June 2016. on physiology, communication, anticipation deterioration introduced 2015. To assess...
Postgraduate medical education in clinical settings poses many challenges secondary to the large volume of knowledge be acquired, competing responsibilities, and fatigue. To address these challenges, a microlearning curriculum using flipped classroom methodologies was created facilitate mastering fundamental physiology formulas by pediatric critical care medicine fellows. Forty were distilled into 5-minute sessions. Fellows provided weekly formula encouraged self-study prior face-to-face...
BACKGROUND: Some studies have found surgery and anesthesia in children to be associated with neurodevelopmental deficits, but specific reasons for this association not been fully explored. This study evaluates intraoperative mean arterial pressure (MAP) during a single ambulatory procedure subsequent mental disorder diagnoses. METHODS: A retrospective observational was performed including ≥28 days <18 years of age electronic anesthetic records between January 1, 2009, April 30, 2017, at...
SummaryDiagnosis for rare genetic diseases often relies on phenotype-driven methods, which hinge the accuracy and completeness of disease phenotypes in underlying annotation knowledgebase. Existing knowledgebases are manually curated with additional annotations found published case reports. Despite their potential, real-world data such as electronic health records (EHRs) have not been fully exploited to derive annotations. Here, we present open (OARD), a real-world-data-derived resource...
There have been numerous reports of neurologic manifestations identified in hospitalized patients infected with SARS-CoV-2, the virus that causes COVID-19. Here, we identify spectrum associated symptoms and diagnoses, define time course their development, examine readmission rates mortality risk posthospitalization a multiethnic urban cohort.We occurrence new diagnoses among laboratory-confirmed SARS-CoV-2 infection New York City. A retrospective cohort study was performed on 532 cases...
Objectives To map the literature regarding assessment of neurocognitive outcomes in PICU survivors. Secondary objectives were to identify gaps and provide data for development a Core Outcome Measures Set domain. Methods Planned, priori analysis was performed from an over-all scoping review Post-Intensive Care Syndrome-pediatrics (PICS-p) functional outcomes. English-language databases registries 1970 2017 searched by medical librarian manuscripts reporting on Post Intensive (PICS-p)....
Abstract Extracorporeal membrane oxygenation (ECMO) is deployed to support children with severe respiratory failure. Unlike neonatal and cardiac ECMO populations, childhood survivors are rarely studied as a distinct population, leading gaps in our understanding of their experiences. This study aimed describe the family patient experiences functional outcomes survivors. Retrospective, mixed-methods, single center cohort who required for failure pediatric intensive care unit survived discharge...
Delirium is an under-recognized problem in critically ill children. Although delirium common adults hospitalized with COVID-19, the relationship between pediatric COVID-19 and has not been described. To address this gap, we characterized children different manifestations of investigated associations among demographic, disease, treatment factors. We hypothesized that multisystem inflammatory syndrome (MIS-C) would be associated a higher incidence given its underlying pathophysiology hyperinflammation.
<title>Abstract</title> Patients admitted to pediatric Intensive Care Unit (PICU) due bronchiolitis have unpredictable length of stay (LOS). The aim this study is observe the difference in relationship between pulse rate variability (PRV) and heart (HRV) for patients with PICU its association LOS. first 12 hours physiologic data after admission were used analysis. Electrocardiogram (ECG) photoplethysmography (PPG) divided into non-overlapping 5-minute segments, R-peak PPG-peak obtained...