A5044638985- COVID-19 Impact on Reproduction
- Antimicrobial Resistance in Staphylococcus
- COVID-19 Clinical Research Studies
- Kawasaki Disease and Coronary Complications
- Streptococcal Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Dermatology and Skin Diseases
- COVID-19 and healthcare impacts
- Bacterial Identification and Susceptibility Testing
- Otolaryngology and Infectious Diseases
- Antifungal resistance and susceptibility
- Nail Diseases and Treatments
- COVID-19 and Mental Health
- Urinary Tract Infections Management
- Pediatric Urology and Nephrology Studies
- Immunodeficiency and Autoimmune Disorders
- Clostridium difficile and Clostridium perfringens research
- Fungal Infections and Studies
- Nosocomial Infections in ICU
- Bacterial Genetics and Biotechnology
- Maternal and fetal healthcare
- Long-Term Effects of COVID-19
- Central Venous Catheters and Hemodialysis
- Viral gastroenteritis research and epidemiology
- DNA and Biological Computing
Weill Cornell Medicine
2020-2025
Presbyterian Hospital
2020-2025
Cornell University
2020-2025
NewYork–Presbyterian Hospital
2020-2023
New York Hospital Queens
2020-2022
Pediatrics and Genetics
2021
Columbia University Irving Medical Center
2017-2020
Columbia University
2018-2019
Davidson College
2009
<h3>Importance</h3> Descriptions of the coronavirus disease 2019 (COVID-19) experience in pediatrics will help inform clinical practices and infection prevention control for pediatric facilities. <h3>Objective</h3> To describe epidemiology, clinical, laboratory features patients with COVID-19 hospitalized at a children's hospital to compare these parameters between without severe disease. <h3>Design, Setting, Participants</h3> This retrospective review electronic medical records from...
<h3>Importance</h3> Accumulating evidence suggests that children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more likely to manifest mild symptoms and at a lower risk of developing disease compared adults. It remains unknown how the immune response in differs from adolescents <h3>Objective</h3> To investigate association age quantity quality SARS-CoV-2 antibody responses. <h3>Design, Setting, Participants</h3> This cross-sectional study used 31 426 test...
Abstract Background The Hamiltonian Path Problem asks whether there is a route in directed graph from beginning node to an ending node, visiting each exactly once. NP complete, achieving surprising computational complexity with modest increases size. This challenge has inspired researchers broaden the definition of computer. DNA computers have been developed that solve complete problems. Bacterial can be programmed by constructing genetic circuits execute algorithm responsive environment and...
Abstract Background Obtaining a urine culture (UCx) in the absence of urinary symptoms and inflammation has been shown to result misdiagnosis over treatment tract infections (UTIs) catheter-associated UTIs adults. Reflex UCx is diagnostic stewardship strategy reduce unnecessary by performing only if urinalysis (UA) meets criteria for infection. Although AAP recommendations reflex pediatrics, there are little data support this approach. We aimed assess potential impact on reducing children....
Staphylococcus aureus is the most common cause of skin and soft tissue infections, yet bacterial genetic changes associated with adaptation to human are not well characterized. S. strains isolated from patients chronic colonization intermittent infection were used determine staphylococcal genotypes or phenotypes skin. We demonstrate that polymorphisms in metabolic genes, particularly those involved tricarboxylic acid cycle, fumarate-succinate axis, generation terminal electron transporters,...
The emergence of the Omicron variant was accompanied by an acute increase in COVID-19 cases and hospitalizations New York City. An increased incidence COVID-19-associated croup children during wave has been recognized, suggesting that there may be other changes clinical symptoms severity. To better understand outcomes health care utilization infected with SARS-CoV-2 wave, we performed a cross-sectional study pediatric patients aged ≤18 years who were tested for emergency departments within...
BACKGROUND AND OBJECTIVES Multisystem inflammatory syndrome in children (MIS-C) is a severe hyperinflammatory illness occurring after acute respiratory coronavirus 2 infection. The optimal treatment of MIS-C unknown, although prior studies have indicated benefits intravenous immunoglobulin (IVIG) and glucocorticoids. We hypothesize that early with glucocorticoids associated shorter hospital length stay (LOS). METHODS This study multicenter retrospective cohort patients hospitalized over...
We describe 2 patients with coronavirus disease who had multiple clinical features suggestive of Kawasaki (KD). Both presented fever lasting &gt;5 days and were found to have rash, conjunctival injection, swollen lips. One patient also extremity swelling, whereas the other developed desquamation fingers. In both cases, laboratory results similar those seen in KD. These highly unusual but features, appeared respond favorably treatment. It remains unclear whether these true KD or...
Pregnancy increases the risk of severe illness due to coronavirus disease 2019 (COVID-19). Thus, prevention acute respiratory syndrome 2 (SARS-CoV-2) transmission in all obstetrical health care settings requires consistent implementation multiple evidence-based practices and consideration local epidemiology, regulations for COVID-19, guidance from Centers Disease Control Prevention Professional Societies. COVID-safe should be implemented patients, visitors/support persons, personnel include...
To reduce both inappropriate testing for and diagnosis of healthcare-onset (HO) Clostridioides difficile infections (CDIs).We performed a retrospective analysis C. from hospitalized children before (October 2017-October 2018) after (November 2018-October 2020) implementing restrictive computerized provider order entry (CPOE).Study sites included hospital A (a ∼250-bed freestanding children's hospital) B ∼100-bed within larger that are part the same multicampus institution.In October 2018, we...
Background: Neonatal intensive care units (NICU) outbreaks caused by methicillin-susceptible Staphylococcus aureus (MSSA) are less commonly reported than methicillin-resistant S. aureus. We report an unusual outbreak of MSSA skin and soft tissue infections (SSTIs) in a level IV NICU investigated whole genome sequencing (WGS) molecular typing. Methods: An investigation was initiated 56-single-bed after four patients developed SSTIs Week 1. Case-patients had positive cultures identified...
Background: Reflexive urine culturing, a strategy wherein cultures are only performed on samples with pyuria, is increasingly being used to reduce unnecessary cultures, healthcare costs, and inappropriate antibiotics. To support implementation of reflexive urine-culture order for pediatric patients aged <18 years, we assessed the proportion that would be avoided calculated sensitivity negative predictive value (NPV) ≥10 white blood cells (WBC) per high-powered field (HPF) threshold...
Abstract Background Children and adults have had different experiences during the COVID-19 pandemic, especially in context of new SARS-CoV-2 variants changing vaccine eligibility. We aimed to compare epidemiology testing, positivity, versus children over multiple pandemic waves a multi-hospital health system New York City. Methods analyzed RT-PCR testing data from 10/1/20 9/11/22 (0-21 years) ( &gt; 21 compared positivity rates 5 City: Wave 2 (10/1/20-6/30/21), 3 (7/1/21-12/1/21), 4...
Abstract Background Hospital-onset bacteremia (HOB) is a quality metric proposed by CDC. HOB caused methicillin-resistant Staphylococcal aureus (MRSA) reported to Centers for Medicare and Medicaid services through the National Healthcare Safety Network (NHSN), yet few studies have described HOB-MRSA epidemiology. Thus, we report epidemiology from 2020-2022 at our multi-hospital health system inform improvement initiatives. Methods We used data submitted NHSN prospectively identify LabID...