Charlene Thomas
A5084724722- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- BRCA gene mutations in cancer
- Medical Imaging Techniques and Applications
- Alzheimer's disease research and treatments
- Genetic Associations and Epidemiology
- Cancer Immunotherapy and Biomarkers
- COVID-19 and healthcare impacts
- Ovarian cancer diagnosis and treatment
- Genomics and Rare Diseases
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Pregnancy and preeclampsia studies
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
- Mass Spectrometry Techniques and Applications
- Genetic factors in colorectal cancer
- Urinary and Genital Oncology Studies
- Adrenal Hormones and Disorders
- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- COVID-19 Impact on Reproduction
- Neuroinflammation and Neurodegeneration Mechanisms
- Diversity and Career in Medicine
- Congenital Diaphragmatic Hernia Studies
Weill Cornell Medicine
2017-2025
Cornell University
2017-2025
University Hospital Llandough
2024
Presbyterian Hospital
2020-2024
New York Hospital Queens
2021-2024
NewYork–Presbyterian Hospital
2020-2024
Molecular Biology Consortium
2023
Cardiff University
2009-2022
Creative Commons
2021
Institute of Population and Public Health
2021
Background Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought identify new genes, using an alternative gene-wide analytical approach tests patterns of association within in the powerful genome-wide dataset International Genomics Project Consortium, comprising over 7 m genotypes from 25,580 cases and 48,466 controls. Principal Findings In addition...
Abstract Background Late‐onset Alzheimer's disease (AD) is heritable with 20 genes showing genome‐wide association in the International Genomics of Project (IGAP). To identify biology underlying disease, we extended these genetic data a pathway analysis. Methods The ALIGATOR and GSEA algorithms were used IGAP to associated functional pathways correlated gene expression networks human brain. Results identified an excess curated biological enrichment association. Enriched areas included immune...
Importance A nonadjuvanted bivalent respiratory syncytial virus (RSV) prefusion F (RSVpreF [Pfizer]) protein subunit vaccine was newly approved and recommended for pregnant individuals at 32 0/7 to 36 6/7 weeks’ gestation during the 2023 2024 RSV season; however, clinical data are lacking. Objective To evaluate association between prenatal vaccination status perinatal outcomes among patients who delivered season. Design, Setting, Participants This retrospective observational cohort study...
BackgroundThe coronavirus disease 2019 pandemic has resulted in unprecedented challenges for the oncology community. For people living with cancer, treatments are interrupted, surgeries cancelled, and regular evaluations rescheduled. People cancer their physicians must balance plausible fears of treatment consequences delaying care.ObjectiveWe aim to evaluate experience women ovarian during pandemic.Study DesignWomen a current or previous diagnosis completed an online survey focusing on...
PURPOSE Novel therapies are needed to extend survival in metastatic castration-resistant prostate cancer (mCRPC). Prostate-specific membrane antigen (PSMA), a cell surface overexpressed PC, provides validated target. This dose-escalation study investigated the safety, efficacy, maximum tolerated dose (MTD), and recommended phase II (RP2D) for 225 Ac-J591, anti-PSMA monoclonal antibody J591 radiolabeled with alpha emitter actinium-225. METHODS Following investigational new drug-enabling...
Rare mutations in AβPP, PSEN1, and PSEN2 cause uncommon early onset forms of Alzheimer's disease (AD), common variants MAPT are associated with risk other neurodegenerative disorders. We sought to establish whether genetic variation these genes confer the form AD which occurs later life (>65 years). therefore tested single-nucleotide polymorphisms at loci for association late-onset (LOAD) a large case-control sample consisting 3,940 cases 13,373 controls. Single-marker analysis did not...
The extent to which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection at different points in the pregnancy timeline may affect maternal and fetal outcomes remains unknown. We sought characterize impact of SARS-CoV-2 proximate remote from delivery on placental pathology. performed a secondary analysis pathology prospective cohort universally tested positive women >20 weeks gestation 1 institution. Subjects were categorized as having or nonacute based <14 ≥14 days...
BACKGROUND New York City (NYC) emerged as an epicenter of the COVID‐19 pandemic, and marginalized populations were affected at disproportionate rates. The authors sought to determine impact on cancer treatment, anxiety, financial distress among low‐income patients with gynecologic during peak NYC pandemic. METHODS Medicaid‐insured women who receiving oncology care 2 affiliated centers contacted by telephone interviews between March 15 April 15, 2020. Demographics clinical characteristics...
Prostate-specific membrane antigen (PSMA) imaging has been suggested as highly sensitive modality for detection of metastases in patients with biochemically recurrent or advanced prostate cancer (PCa). PSMA expression is associated grade and stage a relationship androgen receptor signaling. The aim this study was to evaluate the prognostic utility radiographic men metastatic castration-resistant (mCRPC).Patients mCRPC available baseline were studied. Images by planar/single-photon emission...
Background: The COVID-19 pandemic has resulted in unprecedented challenges for people living with cancer, impacting not only physical health but psychological well-being. response affects the individual as well community and can persist long after outbreak. We aim to assess coping strategies employed by women ovarian cancer during pandemic.Methods: Women a current or prior diagnosis of completed an online survey which included query about pandemic. was distributed from March 30th through...
Currently available SARS-CoV-2 therapeutics are targeted toward moderately to severely ill patients and require intravenous infusions, with limited options for exposed or infected no mild symptoms. Although vaccines have demonstrated protective efficacy, vaccine hesitancy logistical distribution challenges will delay their ability end the pandemic. Hence, there is a need rapidly translatable, easy-to-administer-therapeutics that can prevent disease progression, when administered in early...
ObjectivesApproximately 1% of individuals have a hereditary cancer predisposition syndrome, however, the majority are not aware. Collecting family history (CFH) can triage patients to receive genetic testing. To rigorously assess different methods CFH collection, we compared web-based tool (WBT) usual care (clinician collects CFH) in randomized controlled trial.MethodsNew gynecologic oncology (seen 9/2019–9/2021) were one three arms 2:2:1 allocation ratio: 1) clinician 2) WBT completed at...
172 Background: Up to 1/3 of pts develop biochemical relapse following primary therapy. Many are not cured with salvage local therapy, likely because undetectable distant disease. PSMA is expressed on most PC and can be targeted by radiolabeled J591. 177 Lu a predominantly β-emitting radionuclide also has γ emission which allows imaging. 111 In emitter, some auger for Hormonal therapy effective may increase expression radiosensitivity. this DOD-funded study initiated in the pre-PSMA PET AR...