A5023513227- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Pregnancy and preeclampsia studies
- Infant Development and Preterm Care
- Birth, Development, and Health
- COVID-19 Impact on Reproduction
- Neuroscience and Neuropharmacology Research
- Maternal Mental Health During Pregnancy and Postpartum
- Congenital Diaphragmatic Hernia Studies
- Fetal and Pediatric Neurological Disorders
- Neuroendocrine regulation and behavior
- Neuroscience of respiration and sleep
- Photoreceptor and optogenetics research
- COVID-19 and Mental Health
- Retinal Development and Disorders
- Reproductive System and Pregnancy
- Infant Health and Development
- Preterm Birth and Chorioamnionitis
- Assisted Reproductive Technology and Twin Pregnancy
- Molecular Biology Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Pregnancy-related medical research
- Anesthesia and Neurotoxicity Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Autism Spectrum Disorder Research
Morgan Stanley Children's Hospital
2020-2025
Columbia University Irving Medical Center
2020-2025
Columbia University
2020-2024
New York Hospital Queens
2023
NewYork–Presbyterian Hospital
2023
Ben-Gurion University of the Negev
2022
Soroka Medical Center
2022
Universitair Ziekenhuis Leuven
2022
KU Leuven
2022
Lund University
2022
When contacts are first forming in the developing nervous system, many neurons generate spontaneous activity that has been hypothesized to shape appropriately patterned connections. In Mustela putorius furo , monocular intraocular blockade of retinal waves action potentials by cholinergic agents altered subsequent eye-specific lamination pattern lateral geniculate nucleus (LGN). The projection from active retina was greatly expanded into territory normally belonging other eye, and inactive...
<h3>Importance</h3> Limited data on vertical and perinatal transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) health outcomes neonates born to mothers with symptomatic or asymptomatic disease 2019 (COVID-19) are available. Studies needed inform evidence-based infection prevention control (IP&C) policies. <h3>Objective</h3> To describe the SARS-CoV-2 IP&C practices associated these outcomes. <h3>Design, Setting, Participants</h3> This retrospective cohort...
Associations between in utero exposure to maternal SARS-CoV-2 infection and neurodevelopment are speculated, but currently unknown.To examine the associations during pregnancy, being born COVID-19 pandemic regardless of status, at age 6 months.A cohort infants exposed pregnancy unexposed controls was enrolled Mother Baby Outcomes Initiative Columbia University Irving Medical Center New York City. All women who delivered with a were approached. Women approached based on similar gestational...
Physiological data are routinely recorded in intensive care, but their use for rapid assessment of illness severity or long-term morbidity prediction has been limited. We developed a physiological score preterm newborns, akin to an electronic Apgar score, based on standard signals noninvasively admission neonatal care unit. were able accurately and reliably estimate the probability individual infant's risk severe basis noninvasive measurements. This algorithm was with electronically captured...
Compromised placental function or premature loss has been linked to diverse neurodevelopmental disorders. Here we show that placenta allopregnanolone (ALLO), a progesterone-derived GABA-A receptor (GABAAR) modulator, reduction alters neurodevelopment in sex-linked manner. A new conditional mouse model, which the gene encoding ALLO's synthetic enzyme (akr1c14) is specifically deleted trophoblasts, directly demonstrated ALLO insufficiency led cerebellar white matter abnormalities correlated...
Importance Associations between prenatal SARS-CoV-2 exposure and neurodevelopmental outcomes have substantial public health relevance. A previous study found no association infection parent-reported infant outcomes, but standardized observational assessments are needed to confirm this finding. Objective To assess whether mild or asymptomatic maternal vs during pregnancy is associated with differences at ages 5 11 months. Design, Setting, Participants This cohort included infants of mothers...
Neonatal jaundice can represent a benign physiologic process or be the harbinger of serious illness with associated severe neurotoxicity. The neurological manifestations kernicterus, condition resulting from deposition unconjugated bilirubin in central nervous system, are rarely seen modern neonatal care, but jaundice, which reflects elevated serum levels, is one most common findings period.1 More than half all term infants will develop some and at least 6% have concentration above 12.9...
The coronavirus disease 2019 (COVID-19) pandemic affected people at all ages. Whereas pregnant women seemed to have a worse course of than age-matched non-pregnant women, the risk feto-placental infection is low. Using cohort 66 COVID-19-positive in late pregnancy, we correlated clinical parameters with severity, placental histopathology, and expression viral entry Interferon-induced transmembrane (IFITM) antiviral transcripts. All newborns were negative for SARS-CoV-2. None demographic or...
Abstract Prematurity is associated with significantly increased risk of neurobehavioral pathologies, including autism and schizophrenia. A common feature these psychiatric disorders prefrontal cortex (PFC) inhibitory circuit disruption due to GABAergic interneuron alteration. Cortical interneurons are generated migrate throughout late gestation early infancy, making them highly susceptible perinatal insults such as preterm birth. Term PFC pathology specimens were assessed using...
Premature birth lacks a widely accepted classification that unites features of the clinical presentation with placental pathology. To further explore associations between categories preterm and histology, 109 infants gestational age <34 weeks weight <2000 g were selected and, based on electronic records, classified into labor, prelabor premature rupture membranes, preeclampsia, indicated for maternal factors (other than preeclampsia), fetal factors, diagnosis abruption. Corresponding...
✓ A case is reported of severe unilateral hemispheric edema and localized hemorrhage associated with seizures following endarterectomy an ipsilateral high-grade carotid stenosis. Imaging studies including angiography, computerized tomography (CT), magnetic resonance imaging/angiography, xenon-CT, suggested postoperative cerebral hyperperfusion. Cerebral hyperperfusion syndromes caused by a probable failure vascular autoregulation are rare but potentially serious complications after...