A5063787712- Genetic and Kidney Cyst Diseases
- Microtubule and mitosis dynamics
- Hedgehog Signaling Pathway Studies
- Lymphatic System and Diseases
- Thyroid Disorders and Treatments
- Developmental Biology and Gene Regulation
- RNA modifications and cancer
- ATP Synthase and ATPases Research
- Thyroid Cancer Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- COVID-19 Impact on Reproduction
- Renal and related cancers
Columbia University Irving Medical Center
2018-2024
Columbia University
2021
The coronavirus disease 2019 (COVID-19) pandemic affected people at all ages. Whereas pregnant women seemed to have a worse course of than age-matched non-pregnant women, the risk feto-placental infection is low. Using cohort 66 COVID-19-positive in late pregnancy, we correlated clinical parameters with severity, placental histopathology, and expression viral entry Interferon-induced transmembrane (IFITM) antiviral transcripts. All newborns were negative for SARS-CoV-2. None demographic or...
Cycling cells maintain centriole number at precisely two per cell in part by limiting their duplication to S phase under the control of cycle machinery. In contrast, postmitotic multiciliated (MCCs) uncouple assembly from progression and produce hundreds centrioles absence DNA replication serve as basal bodies for motile cilia. Although some regulators have previously been implicated ciliogenesis, how machinery is employed amplify unclear. We use transgenic mice primary airway epithelial...
Abstract In mice, embryonic dermal lymphatic development is well understood and used to study gene functions in lymphangiogenesis. Notch signaling an evolutionarily conserved pathway that modulates cell fate decisions, which has been shown both inhibit promote Here, we demonstrate distinct roles for Notch4 versus canonical Actively growing lymphatics expressed NOTCH1, NOTCH4, DLL4 correlated with activity. endothelial cells (LECs), activation of induced a subset effectors genes, were...
Purpose: Hepatic vascular lesions (HVLs) are often asymptomatic and diagnosed incidentally. Occasionally, HVLs can cause abdominal pain discomfort, requiring resection. They have been referred by general surgeons hepatologists as "liver hemangiomas". By contrast, specialists in Vascular Anomalies contend that they venous malformations (VMs). To date, there limited studies of HVLs, specifically comparison to true infantile hemangiomas (IHs) VMs. We hypothesize these neither IHs nor VMs, but a...
Abstract The sodium/iodide symporter (NIS) is the essential plasma membrane protein that mediates active iodide (I - ) transport into thyroid gland, first step in biosynthesis of hormones—the master regulators intermediary metabolism. NIS couples inward translocation I against its electrochemical gradient to Na + down gradient. For nearly 50 years before molecular identification, was already molecule at center single most effective internal radiation cancer therapy ever devised: radioiodide...
Abstract In mice, embryonic dermal lymphatic development is well-understood and used to study gene functions in lymphangiogenesis. Notch signaling an evolutionarily conserved pathway that modulates cell fate decisions, which has been shown both inhibit promote Here, we demonstrate distinct roles for Notch4 versus canonical Actively growing lymphatics expressed NOTCH1, NOTCH4 DLL4 correlated with activity. endothelial cells (LECs), activation of induced a subset effectors genes, were...