A5063035887- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- Maternal and Perinatal Health Interventions
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Preterm Birth and Chorioamnionitis
- Assisted Reproductive Technology and Twin Pregnancy
- Neonatal Respiratory Health Research
- Maternal and fetal healthcare
- Genomic variations and chromosomal abnormalities
- Fetal and Pediatric Neurological Disorders
- Pregnancy-related medical research
- Global Maternal and Child Health
- Infant Development and Preterm Care
- Parvovirus B19 Infection Studies
- Congenital Anomalies and Fetal Surgery
- Cardiovascular Issues in Pregnancy
- Maternal Mental Health During Pregnancy and Postpartum
- Ectopic Pregnancy Diagnosis and Management
- Pelvic floor disorders treatments
- Genomics and Rare Diseases
- Bariatric Surgery and Outcomes
- Congenital Heart Disease Studies
- Congenital heart defects research
- Genetic Syndromes and Imprinting
Columbia University
2016-2025
Columbia University Irving Medical Center
2016-2025
National Heart Lung and Blood Institute
2016-2025
University of North Carolina at Chapel Hill
2009-2024
MetroHealth Medical Center
2008-2024
George Washington University
2010-2024
The Ohio State University
2009-2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2012-2024
University of Alabama at Birmingham
2009-2024
University of Utah
2010-2024
Women who were in the 24th to 31st week of gestation and met criteria for mild gestational diabetes mellitus (i.e., an abnormal result on oral glucose-tolerance test but a fasting glucose level below 95 mg per deciliter [5.3 mmol liter]) randomly assigned usual prenatal care (control group) or dietary intervention, self-monitoring blood glucose, insulin therapy, if necessary (treatment group). The primary outcome was composite stillbirth perinatal death neonatal complications, including...
Although repeat cesarean deliveries often are associated with serious morbidity, they account for only a portion of abdominal and overlooked when evaluating morbidity. Our objective was to estimate the magnitude increased maternal morbidity increasing number deliveries.Prospective observational cohort 30,132 women who had delivery without labor in 19 academic centers over 4 years (1999-2002).There were 6,201 first (primary), 15,808 second, 6,324 third, 1,452 fourth, 258 fifth, 89 sixth or...
Women who have had a spontaneous preterm delivery are at greatly increased risk for in subsequent pregnancies. The results of several small trials suggested that 17 alpha-hydroxyprogesterone caproate (17P) may reduce the delivery.
The proportion of women who attempt vaginal delivery after prior cesarean has decreased largely because concern about safety. absolute and relative risks associated with a trial labor in history delivery, as compared elective repeated without labor, are uncertain.
Chromosomal microarray analysis has emerged as a primary diagnostic tool for the evaluation of developmental delay and structural malformations in children. We aimed to evaluate accuracy, efficacy, incremental yield chromosomal compared with karyotyping routine prenatal diagnosis.
To estimate the contributions of biological aging, historical trends, and birth cohort effects on trends in pre-eclampsia United States.Population based retrospective study.National hospital discharge survey datasets, 1980-2010, States.120 million women admitted to for delivery.Temporal changes rates mild severe relation maternal age, year delivery, cohorts. Poisson regression as well multilevel age-period-cohort models with adjustment obesity smoking were incorporated.The rate was 3.4%. The...
The Human Phenotype Ontology (HPO) project, available at http://www.human-phenotype-ontology.org, provides a structured, comprehensive and well-defined set of 10,088 classes (terms) describing human phenotypic abnormalities 13,326 subclass relations between the HPO classes. In addition we have developed logical definitions for 46% all using terms from ontologies anatomy, cell types, function, embryology, pathology other domains. This allows interoperability with several resources, especially...
Because of increased rates respiratory complications, elective cesarean delivery is discouraged before 39 weeks gestation unless there evidence fetal lung maturity. We assessed associations between at term (37 or longer) but and neonatal outcomes.
Cell-free DNA (cfDNA) testing for fetal trisomy is highly effective among high-risk women. However, there have been few direct, well-powered studies comparing cfDNA with standard screening during the first trimester in routine prenatal populations.In this prospective, multicenter, blinded study conducted at 35 international centers, we assigned pregnant women presenting aneuploidy 10 to 14 weeks of gestation undergo both (with measurement nuchal translucency and biochemical analytes)...
Bacterial vaginosis has been associated with preterm birth. In clinical trials, the treatment of bacterial in pregnant women who previously had a delivery reduced risk recurrence.
Research suggests that fetal exposure to magnesium sulfate before preterm birth might reduce the risk of cerebral palsy.
Screening for aneuploid pregnancies is routinely performed after 15 weeks of gestation and has a sensitivity approximately 65 percent, with false positive rate 5 percent. First-trimester markers aneuploidy have been developed, but their use in combination not adequately evaluated clinical practice.We conducted multicenter study screening trisomies 21 18 among patients between 74 97 days gestation, based on maternal age, levels free beta human chorionic gonadotropin pregnancy-associated...
Chorionic villus sampling is a method of prenatal diagnosis in the first trimester pregnancy which tissue for genetic study aspirated from developing placenta by means catheter inserted transcervically under guidance ultrasonography. In this seven-center study, we compared safety and efficacy chorionic 2278 women with those amniocentesis at 16 weeks' gestation 671 women. Both groups were made up primarily well-educated private patients; they recruited had viable pregnancies verified...
Infection with Trichomonas vaginalis during pregnancy has been associated preterm delivery. It is uncertain whether treatment of asymptomatic trichomoniasis in pregnant women reduces the occurrence
In Brief OBJECTIVE: To develop a model based on factors available at the first prenatal visit that predicts chance of successful vaginal birth after cesarean delivery (VBAC) for individual patients who undergo trial labor. METHODS: All women with one prior low transverse underwent labor term vertex singleton gestation were identified from concurrently collected database deliveries 19 academic centers during 4-year period. Using identifiable visit, we analyzed different classification...
Subclinical thyroid disease during pregnancy may be associated with adverse outcomes, including a lower-than-normal IQ in offspring. It is unknown whether levothyroxine treatment of women who are identified as having subclinical hypothyroidism or hypothyroxinemia improves cognitive function their children. We screened singleton before 20 weeks gestation for hypothyroidism, defined thyrotropin level 4.00 mU more per liter and normal free thyroxine (T4) (0.86 to 1.90 ng deciliter [11 24 pmol...
Oxidative stress has been proposed as a mechanism linking the poor placental perfusion characteristic of preeclampsia with clinical manifestations disorder. We assessed effects antioxidant supplementation vitamins C and E, initiated early in pregnancy, on risk serious adverse maternal, fetal, neonatal outcomes related to pregnancy-associated hypertension.
The Perinatal Quality Foundation and the American College of Medical Genetics Genomics, in association with Obstetricians Gynecologists, Society for Maternal-Fetal Medicine, National Genetic Counselors, have collaborated to provide education clinicians laboratories regarding use expanded genetic carrier screening reproductive medicine. This statement does not replace current guidelines, which are published by individual organizations direct practice their constituents. As develop guidelines...
Previous trials have shown that repeat courses of antenatal corticosteroids improve some neonatal outcomes in preterm infants but reduce birth weight and increase the risk intrauterine growth restriction. We report long-term follow-up results children enrolled a randomized trial comparing single corticosteroids. Women at 23 through 31 weeks gestation who remained pregnant 7 days after an initial course were randomly assigned to weekly betamethasone, consisting 12 mg given intramuscularly...