Jennifer Mitchell
A5013684475- BRCA gene mutations in cancer
- Health Systems, Economic Evaluations, Quality of Life
- Antimicrobial Resistance in Staphylococcus
- Acute Ischemic Stroke Management
- Nutrition, Genetics, and Disease
- Streptococcal Infections and Treatments
- Milk Quality and Mastitis in Dairy Cows
- Infective Endocarditis Diagnosis and Management
- Global Cancer Incidence and Screening
- Maternal and Perinatal Health Interventions
- Cell Adhesion Molecules Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Dental Health and Care Utilization
- Bacterial biofilms and quorum sensing
- Lung Cancer Treatments and Mutations
- Biochemical and Structural Characterization
- Lung Cancer Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Venous Thromboembolism Diagnosis and Management
- Multiple and Secondary Primary Cancers
- Cancer Risks and Factors
- Neonatal Respiratory Health Research
- Breast Cancer Treatment Studies
- Congenital Anomalies and Fetal Surgery
- Oral microbiology and periodontitis research
University of Edinburgh
1995-2025
University of California, San Diego
2024
California State University, Dominguez Hills
2024
University of California, San Francisco
2007-2024
Independent Sector
2024
University College Dublin
2010-2023
Wilkes University
2023
Tarleton State University
2022
Oregon Health & Science University
2012-2021
University of Birmingham
2017-2021
Alpha-defensins are peptides secreted by polymorphonuclear cells and provide antimicrobial protection mediated disruption of the integrity bacterial cell walls. Staphylokinase is an exoprotein produced Staphylococcus aureus, which activates host plasminogen. In this study, we analyzed impact interaction between alpha-defensins staphylokinase on staphylococcal growth. We observed that induced extracellular release from cells. Moreover, a direct binding was shown to result in complex...
Ebp are endocarditis- and biofilm-associated pili of Enterococcus faecalis that also important in experimental urinary tract infections (UTIs). Our analyses, using available genomes, found the ebp locus is unique to enterococci. In E. faecalis, very highly conserved only 1/473 isolates tested lacked ebpABC, while 1.2% had bee pilus locus. No other pilus-encoding operon was identified 55 indicating vast majority strains (unlike faecium streptococci) have a single Surface expression studies...
Headache is the predominant disabler in idiopathic intracranial hypertension (IIH). The aim was to characterise headache and investigate association with pressure.IIH:WT a randomised controlled parallel group multicentre trial United Kingdom investigating weight management methods IIH. Participants active IIH (evidenced by papilloedema) body mass index (BMI) ≥35 kg/m2 were recruited. At baseline, 12 months 24 characteristics quality of life outcome measures collected lumbar puncture...
OBJECTIVES: Iatrogenic withdrawal syndrome (IWS) associated with opioid and sedative use for medical purposes has a reported high prevalence morbidity. This study aimed to determine the prevalence, utilization, characteristics of weaning IWS policies/protocols in adult ICU population. DESIGN: International, multicenter, observational, point study. SETTING: Adult ICUs. PATIENTS: All patients aged 18 years older on date data collection who received parenteral opioids or sedatives previous 24...
Abstract Barriers faced by underrepresented groups in academia have increasingly formed the basis of serious discussion, consideration, and policies, recently (in UK) under mantle equality, diversity, inclusivity (EDI). While such recognition has not solved challenges encountered by, for instance, women ethnic minorities, it at least ensured that consideration issues is becoming a normal part policy practice. One group low socioeconomic status (working class) backgrounds, characteristic...
Summary PblA and PblB are prophage‐encoded proteins of Streptococcus mitis strain SF100 that mediate binding to human platelets. The mechanism for surface expression these has been unknown, as they do not contain signal sequences or cell wall sorting motifs. We therefore assessed whether was linked the lytic cycle prophage. Deletion either holin lysin gene resulted in retention cytoplasm, loss from wall. Flow cytometric analysis revealed induction phage replication produced a subpopulation...
The binding of bacteria to human platelets is a likely central mechanism in the pathogenesis infective endocarditis. We have previously found that platelet by Streptococcus mitis SF100 mediated surface components encoded lysogenic bacteriophage, SM1. now demonstrate SM1-encoded lysin contributes via its direct interaction with fibrinogen. Far Western blotting revealed fibrinogen was major membrane-associated protein bound lysin. Analysis purified vitro confirmed these proteins could bind...
Staphylococcus aureus is an important pathogen associated with both human and veterinary disease a common cause of bovine mastitis. Genomic heterogeneity exists between S. strains has been implicated in the adaptation specific to colonise particular mammalian hosts. Knowledge factors required for host specificity virulence understanding pathogenesis management In this study, panel mastitis-associated isolates (n = 126) was tested resistance antibiotics commonly used treat Over half (52%)...
As a proposed mediator between stigma-related stressors and negative mental health outcomes, HIV-related shame has been predictive of increased rates substance use difficulties adhering to antiretroviral treatment among people with HIV. These downstream manifestations have ultimately impeded progress toward national goals End the HIV Epidemic, in part due limited success conventional psychotherapies addressing shame. In pilot clinical trial (N = 12), receipt psilocybin-assisted group therapy...
The fbl gene of Staphylococcus lugdunensis encodes a protein Fbl that is 58 % identical to the clumping factor A (ClfA) aureus . was present in eight clinical isolates S. When expressed on surface Lactococcus lactis it promoted adherence immobilized fibrinogen and cell solution. Purified recombinant region bound dose-dependent manner inhibited both Fbl-expressing ClfA-expressing strains L. fibrinogen. Adherence + also by rabbit anti-Fbl antibodies anti-ClfA antibodies, as well human...