A5064504177- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Legume Nitrogen Fixing Symbiosis
- Bacterial Genetics and Biotechnology
- Enzyme Production and Characterization
- Machine Learning in Bioinformatics
- Phytase and its Applications
- RNA modifications and cancer
- RNA Research and Splicing
- DNA and Biological Computing
- Gene Regulatory Network Analysis
Johns Hopkins University
2015
Davidson College
2009
University of Chicago
2008
Abstract Background The Hamiltonian Path Problem asks whether there is a route in directed graph from beginning node to an ending node, visiting each exactly once. NP complete, achieving surprising computational complexity with modest increases size. This challenge has inspired researchers broaden the definition of computer. DNA computers have been developed that solve complete problems. Bacterial can be programmed by constructing genetic circuits execute algorithm responsive environment and...
The high-throughput sequencing of nuclease-protected mRNA fragments bound to ribosomes, a technique known as ribosome profiling, quantifies the relative frequencies with which different regions transcripts are translated. This has revealed novel translation initiation sites unprecedented scope and furthered investigations into connections between codon biases rates. Yet location being decoded in footprints is still unknown, been complicated by recent observation non-canonical lengths. Here...
We have experimentally and computationally defined a set of genes that form conserved metabolic module in the α-proteobacterium Caulobacter crescentus used this to illustrate schema for propagation pathway-level annotation across bacterial genera. Applying comprehensive forward reverse genetic methods genome-wide transcriptional analysis, we (1) confirmed presence involved catabolism abundant environmental sugar myo-inositol, (2) an operon encoding ABC-family myo-inositol transmembrane...