A5054905807- Immune Cell Function and Interaction
- Immune cells in cancer
- Antimicrobial Resistance in Staphylococcus
- Parasitic Diseases Research and Treatment
- Parasite Biology and Host Interactions
- Sphingolipid Metabolism and Signaling
- Parasites and Host Interactions
- Reproductive System and Pregnancy
- Chronic Lymphocytic Leukemia Research
- RNA regulation and disease
- Bacterial Genetics and Biotechnology
- Ethics in Clinical Research
- RNA Interference and Gene Delivery
- Mosquito-borne diseases and control
- CRISPR and Genetic Engineering
- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Hepatitis C virus research
- Immunodeficiency and Autoimmune Disorders
- HIV Research and Treatment
- Vaccine Coverage and Hesitancy
- Platelet Disorders and Treatments
- Malaria Research and Control
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
Northwestern University
2025
University of Maryland Medical Center
2021
University of Maryland, Baltimore
2020-2021
Columbia University
2019
University of California, Los Angeles
2016-2017
University of California, San Francisco
2014-2016
APLA Health
2015
Abstract Although CD31 expression on human thymocytes has been reported, a detailed analysis of at various stages T cell development in the thymus is missing. In this study, we provide global picture evolution from CD34+ hematopoietic precursor to CD45RA+ mature CD4+ and CD8+ single-positive (SP) cells. Using nine-color flow cytometry, show that highly expressed progenitors stays high until early double-positive stage (CD3−CD4+CD8α+β−). After β-selection, levels become low undetectable. then...
The cytoplasmic human Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3 or A3) cytidine deaminases G and F (A3G A3F) can block the spread of immunodeficiency virus (HIV). HIV counteracts this cell-intrinsic defense through a viral protein called infectivity factor (Vif). Vif causes proteasomal degradation A3G A3F proteins (A3G/F) in HIV-producing cells to ensure virions subsequently released from these cells. Here, we optimized lead compound reported previously boost...
Staphylococcus aureus is the most common cause of skin and soft tissue infections, yet bacterial genetic changes associated with adaptation to human are not well characterized. S. strains isolated from patients chronic colonization intermittent infection were used determine staphylococcal genotypes or phenotypes skin. We demonstrate that polymorphisms in metabolic genes, particularly those involved tricarboxylic acid cycle, fumarate-succinate axis, generation terminal electron transporters,...
In humans, immunity to Plasmodium sp. generally takes the form of protection from symptomatic malaria (i.e., 'clinical immunity') rather than infection ('sterilizing immunity'). contrast, mice infected with develop sterilizing immunity, hindering progress in understanding mechanistic basis clinical immunity. Here we present a novel model which persistently P. chabaudi exhibit limited symptoms despite sustaining patent parasite burdens for many months. Characterization immune responses...
ABSTRACT Minority communities have borne the brunt of COVID-19 disease in United States. Nonwhites contracted most SARS-CoV-2 infections; mortality rates for Black Americans are more than twice those whites. Given this, studying effective ways to prevent and treat these populations should be a research priority, particularly with respect vaccine trials. Federal guidelines from National Institutes Health Food Drug Administration emphasize need inclusion minority groups trials, but none...
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Abstract The innate immune cells mediating macroparasite clearance remain largely undefined. We examined their role in acquired resistance to the parasitic nematode, Nippostrongylus brasiliensis (Nb) hypothesizing that they may mediate markedly accelerated CD4+ cell-independent worm occurring after secondary inoculation. After inoculation, larvae lung are surrounded by macrophages and showed reduced ATP, indicating impaired metabolism. As late as one month Nb macrophages, transferred naïve...
Abstract Sphingosine-1-phosphate receptor 1 (S1P-R1) is essential in mice for homing of lymphoid cells as well egress mature thymocytes from the thymus to periphery. We have recently demonstrated that human thymus, response S1P-R1 its ligand, (S1P), required Herein we demonstrate immune dysregulation accompanying Human Immunodeficiency Virus (HIV) infection alters expression on thymocytes, increasing at both mRNA and protein levels. Moreover, function maintained, assayed by flow cytometry...
Abstract Lack of adequate T cell regeneration in HIV infected individuals is likely due to a defect the entry hematopoietic stem cells (HSC) into and egress naïve from thymus periphery. We studied effect HIV-1 infection on receptors Sphingosine-1-phosphate (S1P), chemotactic sphingolipid mediator, during thymocyte trafficking. Our novel findings show that changes expression patterns S1P-R1 thymocytes about exit thymus. To examine dynamics HSC progenitors infection, mice implanted with human...
Staphylococcus aureus is the most common cause of skin and soft tissue infection, yet genetic changes in these organisms associated with adapation to human are not well characterized. Using S. strains isolated from patients atopic dermatitis (AD) we demonstrate that polymorphisms metabolic genes, particularly those involved tricarboxylic acid (TCA) cycle, fumarate/succinate axis, generation terminal electron transporters unexpectedly common. These AD activated glycolysis, HIF-α, IL-1β IL-18...