A5085284350- Extracellular vesicles in disease
- Cancer Genomics and Diagnostics
- HIV Research and Treatment
- Single-cell and spatial transcriptomics
- Parasites and Host Interactions
- Vagus Nerve Stimulation Research
- Cardiomyopathy and Myosin Studies
- Parasitic Diseases Research and Treatment
- vaccines and immunoinformatics approaches
- Reconstructive Surgery and Microvascular Techniques
- Dental Education, Practice, Research
- Venous Thromboembolism Diagnosis and Management
- Diversity and Career in Medicine
- interferon and immune responses
- Breast Implant and Reconstruction
- Cardiac Valve Diseases and Treatments
- Reproductive tract infections research
- Congenital Heart Disease Studies
- Cardiac Imaging and Diagnostics
- Parasite Biology and Host Interactions
- Adenosine and Purinergic Signaling
- Viral Infections and Vectors
- Body Contouring and Surgery
- Nicotinic Acetylcholine Receptors Study
- Immune Cell Function and Interaction
University of Alabama at Birmingham
2018-2025
Lenox Hill Hospital
2020-2024
Sanofi (United States)
2022-2024
Emory University
2013-2023
B.J. Medical College
2023
Anand Agricultural University
2022
Northwell Health
2006-2022
Texas Children's Hospital
2021
Baylor College of Medicine
2021
Marietta College
2021
The alpha7 subunit-containing nicotinic acetylcholine receptor (alpha7nAChR) is an essential component in the vagus nerve-based cholinergic anti-inflammatory pathway that regulates levels of TNF, high mobility group box 1 (HMGB1), and other cytokines during inflammation. Choline nutrient, a cell membrane constituent, precursor biosynthesis acetylcholine, selective natural alpha7nAChR agonist. Here, we studied potential choline murine endotoxemia sepsis, role mediating suppressive effect on...
The cholinergic antiinflammatory pathway modulates Inflammatory cytokine production through a mechanism dependent on the vagus nerve and α7 subunit of nicotinic acetylcholine receptor. GTS-21 [3-(2,4-dimethoxybenzylidene) anabaseine], selective agonist, inhibits inflammatory in murine human macrophages several models disease vivo, but to date its efficacy monocytes has not been characterized. We report here our findings that attenuates tumor necrosis factor (TNF) interleukin 1β levels whole...
High Mobility Group Box-1 (HMGB1) is a cytokine implicated in the pathogenesis of rheumatoid arthritis (RA) and other inflammatory diseases. The cholinergic anti-inflammatory pathway, vagus nerve-dependent mechanism, inhibits HMGB1 release experimental disease models. Here, we examine relationship between nerve activity patients with RA. We compared RR interval variability, an index cardiac vagal modulation, hsCRP serum levels, scores thirteen RA eleven age- sex-matched controls. In...
Significance Vaccines are one of the most cost-effective public health tools in history and offer a means to probe human immune system. Recent advances have applied systems biology study responses vaccination humans. Here we describe application this “systems vaccinology” approach studying immunity 14- 24-mo-old children with inactivated influenza vaccine, administered or without MF59 adjuvant. These results reveal important new insights about dynamics innate adaptive population, identify...
Whole-genome sequencing and comparative genomic analysis of immune-related genes Cercocebus atys Macaca mulatta identify candidate genes, such as ICAM2 TLR4, that may explain the AIDS resistance C. atys. Sooty mangabeys are a primate model for non-pathogenic simian immunodeficiency virus (SIV) infection. Guido Silvestri colleagues sequenced genome captive sooty mangabey from Yerkes National Primate Research Center in Atlanta, Georgia. They compared this with sequences other primates suggest...
Abstract. Bruchfeld A, Goldstein RS, Chavan S, Patel NB, Rosas‐Ballina M, Kohn N, Qureshi AR, Tracey KJ. (Karolinska Institute, Stockholm, Sweden; The Feinstein Institute for Medical Research, North Shore University Hospital‐LIJ Health System, Manhasset, NY, USA; and Karolinska Sweden) Whole blood cytokine attenuation by cholinergic agonists ex vivo relationship to vagus nerve activity in rheumatoid arthritis. J Intern Med 2010; 268 :94–101. Objective. central nervous system regulates innate...
A rare subset of HIV-infected individuals, designated viremic non-progressors (VNP), remain asymptomatic and maintain normal levels CD4+ T-cells despite persistently high viremia. To identify mechanisms potentially responsible for the VNP phenotype, we compared VNPs (average >9 years HIV infection) to individuals who have similar T-cell counts viral load, but are likely progress if left untreated ("putative progressors", PP), thus avoiding confounding effect differences related substantial T...
B cells play a critical role in the immune response by producing antibodies, which display remarkable diversity. Here we describe bioinformatic pipeline, BALDR (BCR Assignment of Lineage using De novo Reconstruction) that accurately reconstructs paired heavy and light chain immunoglobulin gene sequences from Illumina single-cell RNA-seq data. was accurate for clonotype identification human rhesus macaque influenza vaccine simian immunodeficiency virus induced vaccine-induced plasmablasts...
West Nile virus (WNV) is a neurotropic mosquito-borne flavivirus of global importance. Neuroinvasive WNV infection results in encephalitis and can lead to prolonged neurological impairment or death. Type I interferon (IFN-I) crucial for promoting antiviral defenses through the induction effectors, which function restrict viral replication spread. However, our understanding response mostly derived from analysis bulk cell populations. It becoming increasingly apparent that substantial...
<b><i>Background:</i></b> Desidustat (ZYAN1) is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) that stimulates erythropoiesis. Stabilizing HIF via PHI developing as a new therapeutic approach to treat anemia secondary chronic kidney disease (CKD). This trial evaluated the safety, tolerability, and efficacy of in adult CKD patients with anemia, who were not on dialysis. <b><i>Methods:</i></b> was Phase 2, randomized,...
We have previously shown that activation of muscle receptors by passive stretch (PS) increases heart rate (HR) with little change in blood pressure (BP). proposed PS selectively inhibits cardiac vagal activity. attempted to test this performing during experimental alterations tone. Large decreases tone were induced using either glycopyrrolate or mild rhythmic exercise. Milder achieved altering carotid baroreceptor input: neck (NP) suction (NS). the triceps surae was tested 14 healthy human...
Aim: This study aimed to validate whether predictive factors can predict difficult laparoscopic cholecystectomy(LC). Method: observational prospective was conducted at GCS Medical College, Hospital & Research Centerover a period of 2 years, from July 2022 2024. The studied were • Age ≥50 years Male sex Body mass index (BMI) > 27.5 kg/m² History hospitalization for acute cholecystitis abdominal surgery Palpable gallbladder (GB) Ultrasound (USG) findings: Pericholecystic fluid presence...