A5033978896- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diversity and Career in Medicine
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Dental Education, Practice, Research
- Climate Change and Health Impacts
- Neuroendocrine Tumor Research Advances
- Breast Cancer Treatment Studies
- Gastric Cancer Management and Outcomes
- Breast Lesions and Carcinomas
- Advances in Oncology and Radiotherapy
- Health and Medical Research Impacts
- Hepatocellular Carcinoma Treatment and Prognosis
- Polyomavirus and related diseases
- Healthcare cost, quality, practices
- Colorectal Cancer Screening and Detection
- Antenna Design and Analysis
- Health Systems, Economic Evaluations, Quality of Life
- Gastrointestinal Tumor Research and Treatment
- Liver Disease and Transplantation
- Surgical Simulation and Training
- Cancer, Hypoxia, and Metabolism
- Medical Education and Admissions
- Innovations in Medical Education
Cleveland Clinic
2020-2025
Houston Methodist
2012-2024
Barro Colorado Island
2024
Methodist Hospital
2024
Yale University
2023-2024
Methodist Hospital
2012-2023
Jacobi Medical Center
2021
Loma Linda University Health Care
2019-2021
Loma Linda University
2018-2020
Loma Linda University Medical Center
2020
Abstract Purpose: The heterodimeric transcription factor HIF-2 is arguably the most important driver of clear cell renal carcinoma (ccRCC). Although considered undruggable, structural analyses at University Texas Southwestern Medical Center (UTSW, Dallas, TX) identified a vulnerability in α subunit, which heterodimerizes with HIF1β, ultimately leading to development PT2385, first-in-class inhibitor. PT2385 was safe and active first-in-human phase I clinical trial patients extensively...
Abstract Introduction Minimally invasive Pancreatoduodenectomy (MIPD), or the Whipple procedure, is increasingly utilized. No study has compared laparoscopic (LPD) and robotic (RPD) approaches, impact of learning curve on oncologic, technical, post-operative outcomes remains relatively understudied. Methods The National Cancer Database was queried for patients undergoing LPD RPD from 2010 to 2020 with a diagnosis pancreatic cancer. Outcomes were between approaches using propensity-score...
Abstract Background Immunotherapy is emerging as a promising option for certain locally advanced and metastatic cutaneous malignancies. However, the role of neoadjuvant immunotherapy (NIO) in Merkel cell carcinoma (MCC) with clinically detected regional lymph node metastasis (CDRLNM) has not been fully elucidated. Methods For this study, MCC patients CDRLNM who underwent surgical excision were selected from National Cancer Database (NCDB). Those received NIO propensity-matched those did not,...
Liver metastases occur in about 50% of colorectal cancer cases and drive patient outcomes. Circulating tumor DNA (ctDNA) is emerging as a diagnostic, surveillance, mutational information tool.
Objective: To quantify the rate of progression in surveilled cysts and assess what factors should indicate delayed resection. Background: Side-branch intraductal papillary mucinous neoplasms (SB-IPMNs) are increasingly discovered, making it challenging to identify which patients require resection, thus avoiding inappropriate treatment. Most incidental lesions surveyed, yet consequences that decision remain uncertain. Methods: A prospectively maintained database pancreatic cystic was queried...
Neoadjuvant systemic therapy (NAST) is a treatment option for intrahepatic cholangiocarcinoma (iCCA), though its impact on short-term oncologic outcomes and long-term survival remains relatively unknown.
ABSTRACT Introduction Pancreatic ductal adenocarcinoma (PDAC) of the body/tail is notably different than PDAC in head pancreas. Surgery plus chemotherapy known to improve outcomes for all PDAC. The sequence this therapy well studied cancers yet has never been evaluated systematically relation distal pancreatectomy (DP). Methods Patients receiving DP and who received were included. compared neoadjuvant systemic (NAST) only, adjuvant (AST) both NAST + AST, total (TNT), defined as > 24 weeks...
Cultures of blood and/or cerebrospinal fluid from four 1,013 bone marrow transplant recipients treated at our center between January 1972 and April 1994 were positive for Listeria monocytogenes. The overall occurrence listeriosis was 0.39 case per 100 transplantations. Allograft had received prior treatment with parenteral methylprednisolone, thus supporting an association corticosteroids. Treatment ampicillin (200 mg/[kg · d]) gentamicin is recommended a minimum 3 weeks before oral therapy....
Abstract Introduction A minimum lymph node harvest (LNH) of 12 is the current standard for appropriate nodal staging in resectable rectal cancer. However, rise neoadjuvant chemoradiation (NCRT) and total therapy (TNT) has been associated with decreasing number LNH. We hypothesize that as tumor response to increases, optimum LNH achieve should decrease. Methods Patients clinical stage III adenocarcinoma who underwent NCRT/TNT followed by resection were identified from National Cancer...
Branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) are becoming more prevalent with advanced medical imaging and account for most of pancreatic cystic (PCNs). Most incidental lesions should be surveyed, resection reserved specific, high-risk cases. Solid organ transplantation candidates may high risk before transplant will require systemic immunosuppression after transplant, which has been theorized to alter the natural history IPMN. We aimed describe progression in surveilled...