A5058699593- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Liver Diseases and Immunity
- Transplantation: Methods and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Organ Donation and Transplantation
- Viral-associated cancers and disorders
- Inflammatory Bowel Disease
- Pneumocystis jirovecii pneumonia detection and treatment
- Renal Transplantation Outcomes and Treatments
- Nonmelanoma Skin Cancer Studies
- Long-Term Effects of COVID-19
- Esophageal Cancer Research and Treatment
- Pediatric Urology and Nephrology Studies
- Antifungal resistance and susceptibility
- Genetic and Kidney Cyst Diseases
- Lymphoma Diagnosis and Treatment
- Fungal Infections and Studies
- Cutaneous Melanoma Detection and Management
- Eosinophilic Disorders and Syndromes
- Hepatitis Viruses Studies and Epidemiology
Cleveland Clinic
2016-2025
Cleveland Clinic Lerner College of Medicine
2024
Case Western Reserve University
2024
Cleveland Clinic Florida
2018
Shariati Hospital
2009-2011
Tehran University of Medical Sciences
2009-2011
Iran University of Medical Sciences
2006
Objective: Assess cost and complication outcomes after liver transplantation (LT) using normothermic machine perfusion (NMP). Background: End-ischemic NMP is often used to aid logistics, yet its impact on LT remains unclear, as does true costs associated with transplantation. Methods: Deceased donor recipients at 2 centers (January 1, 2019, June 30, 2023) were included. Retransplants, splits, combined grafts excluded. (OrganOx-Metra) was implemented in October 2022 for extended-criteria...
Ex situ normothermic machine perfusion (NMP) helps increase the use of extended criteria donor livers. However, impact an NMP program on waitlist times and mortality has not been evaluated. Adult patients listed for liver transplant (LT) at 2 academic centers from January 1, 2015, to September 2023, were included (n=2773) allow all ≥6 months follow-up listing. Routine was implemented October 14, 2022. Waitlist outcomes compared pre-NMP pre-acuity circles (n=1460), with acuity (n=842),...
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death and sixth most diagnosed malignancy worldwide. Serum alpha-fetoprotein (AFP) traditional, ubiquitous biomarker for HCC. However, there has been an increasing call use multiple biomarkers to optimize care these patients. AFP, AFP-L3, prothrombin induced by vitamin K absence II (DCP) have described clinical utility HCC, but unfortunately, they also well established significant limitations. Circulating tumor DNA...
We describe a novel pre-liver transplant (LT) approach in colorectal liver metastasis, allowing for improved monitoring of tumor biology and reduction disease burden before committing patient to transplantation. Patients undergoing LT metastasis at Cleveland Clinic were included. The described protocol involves intensive locoregional therapy with systemic chemotherapy, aiming reach minimal revealed by positron emission tomography scan carcinoembryonic Ag. no detectable or irreversible...
Background. This study compares selection criteria for liver transplant (LT) hepatocellular carcinoma (HCC) inclusivity and predictive ability to identify the most permissive that maintain patient outcomes. Methods. The Scientific Registry of Transplant Recipients (SRTR) database was queried deceased donor LT’s HCC (2003–2020) with 3-y follow-up; these data were compared a 2-center experience. Milan, University California, San Francisco (UCSF), 5-5-500, Up-to-seven (U7), HALT-HCC,...
Background: Liver transplantation (LT) is a well-established treatment for hepatocellular carcinoma (HCC), but there are ongoing debates regarding outcomes and selection. This study examines the experience of LT HCC at high-volume centre. Methods: A prospectively maintained database was used to identify patients undergoing from 2000 2020 with more than or equal 3-years follow-up. Data were obtained centre electronic medical records. The Metroticket 2.0 HCC-specific 5-year survival scale...
Primary prophylaxis of spontaneous bacterial peritonitis (SBP) may provide a survival advantage in cirrhotic patients with ascites and has become an integral part clinical practice. Rifaximin is poorly absorbable antibiotic broad spectrum antibacterial action low risk introducing resistance.To determine whether rifaximin associated decreasing the SBP improving transplant-free ascites.The medical records all adult liver cirrhosis large justifying paracentesis evaluated our clinic (2003 to...
Background/Aims The American Association for the Study of Liver Diseases recommends ultrasound (US) screening hepatocellular carcinoma (HCC) among cirrhotic patients, regardless body mass index (BMI), every 6 months. We examined US sensitivity diagnosis HCC in obese patients. Methods transplant patients data with explant was used (January 2012-December 2017). All underwent liver within 3 months HCC. Number/size lesions were extracted from radiologic and pathologic reports. Obesity defined as...
Circulating tumor DNA (ctDNA) is emerging as a promising, non-invasive diagnostic and surveillance biomarker in solid organ malignancy. However, its utility before after liver transplant (LT) for patients with primary secondary cancers still underexplored.
SARS-CoV2, first described in December 2019, was declared a pandemic by the World Health Organization March 2020. Various surgical and medical societies promptly published guidelines, based on expert opinion, managing patients with COVID-19, consensus to postpone elective surgeries procedures. We describe case of an orthotopic liver transplantation (OLT) young female who presented acute failure secondary acetaminophen toxicity manage abdominal pain setting positive SARS-CoV2 test. Despite...
The objectives of our study were to examine and compare patient graft survival over a 5-year period across BMI groups, immediate short-term complications post-LT. This was retrospective that examined all liver transplants occurred at institution between January 2015-October 2022. Patients divided into 4 groups (n = 888): normal-overweight (BMI 18.5- 29.9 kg/m2), class I obesity 30–34.9 II 35–39.9 III ≥40 kg/m2) patients. Kaplan Meier curves with the log rank test created assess outcomes...
Current recommended regimens to treat patients with hepatitis C virus (HCV) infection after liver transplantation include the use of ribavirin (RBV). Limited data are available on efficacy RBV-free posttransplant, particularly sofosbuvir (SOF)/ledipasvir (LDV) without RBV in this patient population. We aimed assess and safety SOF/LDV fixed-dose combination HCV recurrence posttransplant.This is a retrospective study 46 posttransplant. was used for 12 weeks early-stage fibrosis (F0-F2) or 24...
Branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) are becoming more prevalent with advanced medical imaging and account for most of pancreatic cystic (PCNs). Most incidental lesions should be surveyed, resection reserved specific, high-risk cases. Solid organ transplantation candidates may high risk before transplant will require systemic immunosuppression after transplant, which has been theorized to alter the natural history IPMN. We aimed describe progression in surveilled...