A5047595060- Organ Transplantation Techniques and Outcomes
- Trauma and Emergency Care Studies
- Liver Disease and Transplantation
- Pharmacological Effects and Toxicity Studies
- Renal Transplantation Outcomes and Treatments
- Histone Deacetylase Inhibitors Research
- Patient Satisfaction in Healthcare
- Telemedicine and Telehealth Implementation
- Mobile Health and mHealth Applications
- COVID-19 and healthcare impacts
- Cardiac Arrest and Resuscitation
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Diversity and Career in Medicine
- Cardiac, Anesthesia and Surgical Outcomes
- Emergency and Acute Care Studies
- Social Media in Health Education
- Renal and Vascular Pathologies
- Innovations in Medical Education
- Hip and Femur Fractures
- Traumatic Brain Injury Research
- Extracellular vesicles in disease
- Disaster Response and Management
Cleveland Clinic
2024-2025
University of Michigan–Ann Arbor
2017-2022
Michigan Medicine
2020-2021
Northwestern University
2020-2021
San Francisco General Hospital
2021
University of Colorado Denver
2021
Health Net
2021
Denver Health Medical Center
2021
Mercy Health
2021
Massachusetts General Hospital
2021
Not Dying Alone When the wife of a severely ill patient with Covid-19 is told she can’t visit him, her anger quickly gives way to pleading — “What if I only spent 5 minutes and left?” How can we ha...
BACKGROUND Early single-dose treatment with human mesenchymal stem cell–derived exosomes promotes neuroprotection and blood-brain barrier integrity in models of traumatic brain injury (TBI) hemorrhagic shock (HS) swine. The impact an early single dose on late survival (7 days), however, remains unknown. We sought to evaluate the exosome neurologic outcomes, lesion size, inflammatory cytokines, apoptotic markers, mediators neural plasticity a 7-day model. METHODS Yorkshire swine were...
<h3>Importance</h3> Rehospitalization after major surgery is common and represents a significant cost to the health care system. Little known regarding causes of these readmissions degree which they may be preventable. <h3>Objective</h3> To evaluate are potentially <h3>Design, Setting, Participants</h3> This retrospective cohort study used weighted sample 1 937 354 patients from 2017 National Readmissions Database all adult inpatient hospitalizations for 7 surgical procedures. Statistical...
Abstract BACKGROUND: Spinal surgery costs vary significantly across hospitals and regions, but there is insufficient understanding of what drives this variation. OBJECTIVE: To examine the factors underlying cost variation for lumbar laminectomy/discectomy fusions. METHODS: We obtained patient information (age, gender, race, severity illness, risk mortality, population county residence, median zipcode income, insurance status, elective vs nonelective admission, length stay) hospital data...
Hemorrhage is a leading cause of mortality in trauma. Resuscitative endovascular balloon occlusion the aorta (REBOA) can control hemorrhage, but distal ischemia, subsequent reperfusion injury, and need for frequent titration remain problems. Improved device design allow partial REBOA (pREBOA) that may provide hemorrhage while also perfusing distally without significant provider titration.Female Yorkshire swine (N = 10) were subjected to 40% hemorrhagic shock 1 hour (mean arterial pressure...
We have shown that administration of mesenchymal stem cell-derived exosomes (single dose given within 1 hour) in models traumatic brain injury (TBI) and hemorrhagic shock is neuroprotective. The precise mechanisms responsible for the neuroprotection are not fully understood. This study was designed to investigate transcriptomic changes associated with this treatment strategy.Yorkshire swine (40-45 kg) were subjected a severe TBI (12-mm cortical impact) (40% estimated total blood volume). One...
Outcome after traumatic injury has typically been limited to the determination at time of discharge or brief follow-up. This study investigates natural history long-term survival trauma.All highest-level activation patients prospectively enrolled in an ongoing cohort from 2005 2012 were selected. To allow for follow-up, had be least 1 year before latest available data National Death Index (NDI, 2013). Time and cause mortality was determined based on death certificates. Survival status by...
The COVID-19 pandemic has resulted in dramatically disproportionate death rates among African American and Latino communities. Although the numbers are alarming, they should not surprise surgeons. There decades of data demonstrating worse surgical outcomes for racial minorities.1 past been an unfortunate predictor how acute shock like would manifest within chronically marginalized communities form delayed access poor outcomes. created a large scale disruption health care delivery as...
Abstract Postoperative patients are at risk of life-threatening complications such as hemodynamic decompensation or arrhythmia. Automated detection with risks via a real-time clinical decision support system may provide opportunities for early and timely interventions that can significantly improve patient outcomes. We utilize multimodal features derived from digital signal processing techniques tensor formation, well the electronic health record (EHR), to create machine learning models...
BACKGROUND No agents that are specifically neuroprotective currently approved to emergently treat patients with traumatic brain injury (TBI). The histone deacetylase inhibitor, high-dose valproic acid (VPA) has been shown have cytoprotective potential in models of combined TBI and hemorrhagic shock, but it not tested an isolated model. We hypothesized VPA, administered after TBI, will penetrate the injured brain, attenuate lesion size, activate prosurvival pathways. METHODS Yorkshire swine...