A5101403808- Pharmacological Effects and Toxicity Studies
- Trauma and Emergency Care Studies
- Pain Management and Opioid Use
- Histone Deacetylase Inhibitors Research
- Cardiac Arrest and Resuscitation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Blood transfusion and management
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 and healthcare impacts
- Pelvic and Acetabular Injuries
- Pituitary Gland Disorders and Treatments
- Hepatitis C virus research
- Enhanced Recovery After Surgery
- Healthcare Policy and Management
- Disaster Response and Management
- Parathyroid Disorders and Treatments
- Breast Implant and Reconstruction
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury Research
- Sepsis Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Nerve injury and regeneration
- Venous Thromboembolism Diagnosis and Management
Royal Marsden Hospital
2023
University of Michigan–Ann Arbor
2019-2021
Northwestern University
2020-2021
Michigan Medicine
2020-2021
Royal Marsden NHS Foundation Trust
2021
Northwestern Memorial Hospital
2020
University of California Davis Medical Center
2020
David Grant USAF Medical Center
2020
Novem (Netherlands)
2020
Washington University in St. Louis
2020
Purpose Fear of cancer recurrence (FCR) is prevalent, distressing, and long lasting. This study evaluated the impact a theoretically/empirically based intervention (ConquerFear) on FCR. Methods Eligible survivors had curable breast or colorectal melanoma, completed treatment (not including endocrine therapy) 2 months to 5 years previously, were age > 18 years, scores above clinical cutoff FCR Inventory (FCRI) severity subscale at screening. Participants randomly assigned one-to-one ratio...
Hemorrhage is a leading cause of mortality in trauma. Resuscitative endovascular balloon occlusion the aorta (REBOA) can control hemorrhage, but distal ischemia, subsequent reperfusion injury, and need for frequent titration remain problems. Improved device design allow partial REBOA (pREBOA) that may provide hemorrhage while also perfusing distally without significant provider titration.Female Yorkshire swine (N = 10) were subjected to 40% hemorrhagic shock 1 hour (mean arterial pressure...
BACKGROUND Trauma is a leading cause of death, and traumatic brain injury one the hallmark injuries current military conflicts. Valproic acid (VPA) administration in high doses (300–400 mg/kg) improves survival lethal trauma models, but effectiveness lower on unknown. This information essential for properly designing upcoming clinical trials. We, therefore, performed study to determine lowest dose at which VPA model injuries. METHODS Swine were subjected (10-mm cortical impact), 40% blood...
BACKGROUND No agents that are specifically neuroprotective currently approved to emergently treat patients with traumatic brain injury (TBI). The histone deacetylase inhibitor, high-dose valproic acid (VPA) has been shown have cytoprotective potential in models of combined TBI and hemorrhagic shock, but it not tested an isolated model. We hypothesized VPA, administered after TBI, will penetrate the injured brain, attenuate lesion size, activate prosurvival pathways. METHODS Yorkshire swine...
Objectives: To examine the effectiveness of anticoagulation among patients discharged from hospital on warfarin in care general practitioners (GPs). Design and setting: A historical cohort with questionnaires to a major metropolitan teaching their GPs. Participants: Patients between 1 February 1995 31 January 1996 identified pharmacy records as being prescribed warfarin, treating Main outcome measures: Frequency testing levels international normalised ratio prothrombin time (INR) within six...
Traumatic brain injury (TBI) and hemorrhage remain the leading causes of death after trauma. We have previously shown that a dose valproic acid (VPA) at (150 mg/kg) can decrease lesion size hasten neurologic recovery. The current Food Drug Administration-approved VPA is 60 mg/kg. evaluate outcomes single level currently within in swine subjected to TBI hemorrhagic shock.Swine (n = 5/group) were 40% blood volume hemorrhage. Animals remained shock for 2 hours before randomization normal saline...
Trauma is the leading cause of death for young Americans. Nonspecific histone deacetylase inhibitors, such as valproic acid, have been shown to improve survival in preclinical models lethal trauma, hemorrhage, and sepsis. The doses needed achieve a benefit are higher than Food Drug Administration-approved doses, nonspecificity raises concerns about unintended adverse effects. isoform-specific 6 inhibitor, ACY-1083, has found be efficacious acid rodent model hemorrhagic shock. We hypothesized...
BACKGROUND We lack specific treatments for traumatic brain injury (TBI), which remains the leading cause of trauma-related morbidity and mortality. Treatment with valproic acid (VPA) improves outcomes in models severe TBI concurrent hemorrhage. However, it is unknown if VPA will have similar benefits after isolated nonlethal TBI, more common clinical scenario. The goal this study was to evaluate effect treatment a preclinical swine model on neurologic lesion size perform detailed...
Traumatic brain injury (TBI) is a leading cause of trauma-related morbidity and mortality. Valproic acid (VPA) has been shown to attenuate lesion size swelling within the first few hours following TBI. Because injured neurons are sensitive metabolic changes, we hypothesized that VPA treatment would alter profile in perilesional tissues create neuroprotective environment.We subjected swine combined TBI (12-mm cortical impact) hemorrhagic shock (40% blood volume loss 2 hypotension) randomized...
The authors report a case of 7-year-old boy who sustained penetrating injury splinter wood to the knee. Arthroscopic examination, removal visualised foreign material and washout did not alleviate symptoms pain swelling in its entirety. Microbiology cultures also failed determine cause on-going symptoms. Five days later, patient underwent mini arthrotomy through lateral incision, which demonstrated synovitis, remaining embedded body from condyle. Although advocate arthroscopy as surgeon’s...
BACKGROUND Hemorrhage is the leading cause of preventable death in trauma. Future military conflicts are likely to be austere environments, where prolonged damage-control resuscitation (p-DCR) may required for 72 hours before evacuation. There a need demonstrate that p-DCR feasible and optimize its logistics. Dried plasma (DP) practical alternative conventional blood products settings, valproic acid (VPA) improves survival preclinical models trauma hemorrhage. We performed current experiment...
Trauma and sepsis are individually two of the leading causes death worldwide. When combined, mortality is greater than 50%. Thus, it imperative to have a reproducible reliable animal model study effects polytrauma test novel treatment options. Porcine models more translatable humans rodent due similarities in anatomy physiological response. We embarked on develop lethal intra-abdominal sepsis, which was lethal, though potentially salvageable with treatment.Our laboratory has well-established...
Intraosseous (IO) drug delivery may be necessary in emergency situations when intravenous access is unattainable. Valproic acid (VPA) a histone deacetylase inhibitor that has previously been shown to improve survival preclinical models of lethal polytrauma. In this study, we sought compare serum levels intravenously and IO-delivered VPA, analyze the effect VPA.Swine were subjected 40% blood volume hemorrhage, brain injury, femur fracture, rectus crush injury liver laceration. After 1 hour...
Background: Fenofibrate increases renal clearance of uric acid (UA). Relationships between baseline and short-term changes in plasma UA with fenofibrate subsequent cardiovascular risk patients type 2 diabetes (T2D) are unknown. Method: Post hoc analyses the FIELD trial explored relationships CVD events 1) level; 2) change level over 6-week single-blind active run-in. Results: The showed 11% fewer T2D assigned to compared placebo 5 years (HR = 0.89, 95% CI: 0.80-0.99, p 0.035). Baseline...
Chronic Kidney Disease Stage 5 (CKD-5) imparts a 4-fold increase in minimal trauma fracture with substantial mortality following hip fracture. Bone disease CKD is complex, characterised by abnormal levels of PTH, calcium, phosphate, ALP, and vitamin D, manifesting as condition known CKD-Mineral Disorder (CKD-MBD). While bisphosphonates (BPs) are widely used the management osteoporosis, their therapeutic role when end-stage renal function bone co-exist remains unclear. This 15-year...