A5004881434- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Breast Lesions and Carcinomas
- Reconstructive Surgery and Microvascular Techniques
- Global Cancer Incidence and Screening
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- BRCA gene mutations in cancer
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Cardiac Ischemia and Reperfusion
- HER2/EGFR in Cancer Research
- Radiomics and Machine Learning in Medical Imaging
- Body Image and Dysmorphia Studies
- Cancer Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Organ Transplantation Techniques and Outcomes
- Sepsis Diagnosis and Treatment
- AI in cancer detection
- Body Contouring and Surgery
- Liver Disease and Transplantation
- Advances in Oncology and Radiotherapy
- Cardiac, Anesthesia and Surgical Outcomes
- Reconstructive Facial Surgery Techniques
- PARP inhibition in cancer therapy
Royal Marsden Hospital
2017-2024
Royal Marsden NHS Foundation Trust
2017-2024
Institute of Cancer Research
2021-2024
Aretaeio Hospital
2011-2019
National Health Service
2018
Versus Arthritis
2018
Yale University
2017
National and Kapodistrian University of Athens
2008-2016
Imperial College Healthcare NHS Trust
2014-2015
Charing Cross Hospital
2014
Image-guided breast biopsy of a residual imaging abnormality or tumor bed after neoadjuvant chemotherapy (NACT) is increasingly used to assess cancer, facilitate risk-adaptive surgery, and potentially identify exceptional responders in whom local therapy may be de-escalated.To further the accuracy post-NACT image-guided predict cancer breast.This diagnostic study analyzed multicenter patient-level data patients with who were treated NACT underwent before surgery at Royal Marsden Hospital...
The nodal burden of patients with residual isolated tumor cells (ITCs) in the sentinel lymph nodes (SLNs) after neoadjuvant chemotherapy (NAC) (ypN0i+) is unknown, and axillary management not standardized. We investigated rates additional positive (LNs) at node dissection (ALND) oncologic outcomes ypN0i+ treated without ALND.
Hemorrhagic shock and resuscitation is frequently associated with liver ischemia-reperfusion injury. The aim of the study was to investigate whether hypoxemic attenuates injury.Anesthetized, mechanically ventilated New Zealand white rabbits were exsanguinated a mean arterial pressure 30 mmHg for 60 minutes. Resuscitation under normoxemia (Normox-Res group, n = 16, PaO(2) 95-105 mmHg) or hypoxemia (Hypox-Res 15, 35-40 followed, modifying FiO(2). Animals not subjected constituted sham group (n...
We evaluated the role of sildenafil in a rat liver ischemia-reperfusion model. Forty male rats were randomly allocated four groups. The sham group underwent midline laparotomy only. In group, was administered intraperitoneally 60 minutes before laparotomy. (I/R) subjected to 45 hepatic ischemia followed by 120 reperfusion, while sild+I/R similar pattern I/R after administration sildenafil, ischemia. Two hours serum levels alanine aminotransferase (ALT) and aspartate (AST) measured...
Abstract Background Breast angiosarcomas are rare tumours of vascular origin. Secondary angiosarcoma occurs following radiotherapy for breast cancer. Angiosarcomas have high recurrence and poor survival rates. This is concerning owing to the increasing use adjuvant treatment invasive cancer ductal in situ (DCIS), which could explain rising incidence angiosarcoma. Outcome data limited provide a evidence base treatment. paper presents national, trainee-led, retrospective, multicentre study...
Cystic disease of the spleen is an uncommon entity in general population. Most cases result from parasitic infection by Echinococcus granulosus, a form called splenic hydatid (SHD), with reported frequency 0.5-6.0% within abdominal hydatidosis. On contrary, isolated involvement very even endemic regions. Two primary SHD managed open and laparoscopic radical surgery our department are herein. Primary rare non-specific symptoms underlying clinical suspicion physician for prompt diagnosis....
To evaluate whether the level of hypotension during hemorrhagic shock may influence oxidative and inflammatory responses developed post-ischemic resuscitation.Fifteen rabbits were equally allocated into three groups: sham-operated (group sham); bled within 30 minutes to mean arterial pressure (MAP) 40 mmHg shock-40); MAP shock-30). Shock was maintained for 60 min. Resuscitation performed by reinfusing shed blood with two volumes Ringer's lactate sampled estimation serum levels...
Increased levels of cytokines or reactive oxygen species (ROS) in the bronchoalveolar lavage (BAL) fluid are associated with acute lung injury after ischemia/reperfusion. We investigated correlation these markers degree a rabbit model hemorrhagic shock. Rabbits, maintained by mechanical ventilation, were left untreated (control) subjected to shock withdrawing blood (n = 12 for each group). Shock animals re-infused their shed resuscitation. At end experiment, BAL was recovered, which...
The global pandemic COVID-19 has placed healthcare systems under enormous pressures as the number of affected individuals requiring hospital-based care increases daily. Consequently, medical resources for other highly treatable illnesses such cancer are potentially compromised, dynamic, transparent prioritization to maintain non-COVID-19 that is essential and time-critical preserve life but also nationally equitable in publicly funded systems. This particularly relevant breast cancer,...
Hydrodissection (HD) is a method to create subcutaneous and prepectoral plane during mastectomy using mixture of crystalloid solution with local anesthetic epinephrine. The aim this study was evaluate postoperative complications surgical outcomes technique compared standard mastectomy.This retrospective cohort patients who underwent bilateral risk-reducing, nipple-sparing immediate implant-based reconstruction through an inframammary crease incision either electrocautery (control group) or...