A5088685953- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer and Skin Lesions
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- AI in cancer detection
- Wnt/β-catenin signaling in development and cancer
- Cancer Immunotherapy and Biomarkers
- Digital Imaging for Blood Diseases
- Radiomics and Machine Learning in Medical Imaging
- Breast Implant and Reconstruction
- HER2/EGFR in Cancer Research
- Ear and Head Tumors
- Cancer-related gene regulation
- Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Cervical Cancer and HPV Research
- Advanced Radiotherapy Techniques
- Ovarian cancer diagnosis and treatment
- Lung Cancer Diagnosis and Treatment
- Tumors and Oncological Cases
- Kruppel-like factors research
- Medical Imaging Techniques and Applications
- Soft tissue tumor case studies
Memorial Sloan Kettering Cancer Center
2018-2025
CDH1 (E-cadherin) bi-allelic inactivation is the hallmark alteration of breast invasive lobular carcinoma (ILC), resulting in its discohesive phenotype. A subset ILCs, however, lack genetic/epigenetic inactivation, and their genetic underpinning unknown. Through clinical targeted sequencing data reanalysis 364 primary we identified 25 ILCs lacking alterations. promoter methylation was frequent (63%) these cases. Targeted revealed 3 harboring AXIN2 deleterious fusions (n = 2) or...
The nodal burden of patients with residual isolated tumor cells (ITCs) in the sentinel lymph nodes (SLNs) after neoadjuvant chemotherapy (NAC) (ypN0i+) is unknown, and axillary management not standardized. We investigated rates additional positive (LNs) at node dissection (ALND) oncologic outcomes ypN0i+ treated without ALND.
Flat epithelial atypia (FEA) is an alteration of terminal duct lobular units by a proliferation ductal epithelium with low-grade atypia. No consensus exists on whether the diagnosis FEA in core needle biopsy (CNB) requires excision (EXC). We retrospectively identified all in-house CNBs obtained between January 2012 and July 2018 FEA. reviewed CNB slides assessed radiologic-pathologic concordance. An upgrade was defined as invasive carcinoma (IC) and/or situ EXC. The EXC upgraded cases were...
Context.— The Ventana programmed death ligand-1 (PD-L1) SP142 immunohistochemical assay (IHC) is approved by the US Food and Drug Administration as companion diagnostic to identify patients with locally advanced or metastatic triple-negative breast cancer for immunotherapy atezolizumab, a monoclonal antibody targeting PD-L1. Objective.— To determine interobserver variability in PD-L1 IHC interpretation invasive carcinoma. Design.— pathology database was interrogated all diagnosed primary...
Purpose Evaluate the clinical presentation and imaging findings of breast implant-associated anaplastic large cell lymphoma (BIA ALCL) at a US cancer center. Materials Methods HIPAA-compliant IRB approved retrospective study, for which informed consent was waived. The Hospital Information System screened women who underwent implant reconstruction were diagnosed with BIA ALCL between 2010 2016. Two radiologists reviewed images in consensus. Clinical characteristics summarized using means...
Abstract Breast adenoid cystic carcinoma (AdCC) is a rare subtype of triple negative breast cancer. Two morphologic variants are described, namely classic AdCC (C-AdCC) and solid basaloid (SB-AdCC). Recent studies have shown that the SB-AdCC variant has significantly worse prognosis than C-AdCC. Due to rarity SB-AdCC, no standard recommendations available for its management. Data on use benefit chemotherapy in patients with sparse response neoadjuvant not been reported. We present clinical...
False-negative (FN) intraoperative frozen section (FS) results of sentinel lymph nodes (SLN) have been reported to be more common after neoadjuvant chemotherapy (NAC) in the primary surgical setting. We evaluated SLN FS assessment breast cancer patients treated with NAC determine FN rate and histomorphologic factors associated results. Patients who had following from July 2008 2017 were identified. Of 711 cases, 522 negative, 181 positive, 8 deferred. The was 5.4% (28/522). There no...
Immunotherapy for the treatment of programmed death-ligand 1 (PD-L1) positive locally advanced or metastatic triple negative breast cancer may benefit patients with metaplastic (MpBC). Previous study PD-L1 in MpBC scored tumor cells (TCs), different from Food and Drug Administration-approved scoring methods. We sought to define expression MpBCs evaluate concordance 3 assays. Primary, naive treated at our Center 1998 2019 were identified. was assessed using SP142, E1L3n, 73-10. evaluated on...
Some histologic special types of breast carcinoma harbor specific recurrent genetic alterations that are not seen in other (no type), namely adenoid cystic carcinoma, secretory and tall cell with reversed polarity. These tumors have unique morphologic features, triple-negative, is, do express hormone receptors or HER2, generally associated a favorable prognosis. Adenoid like its counterpart organs, shows MYB-NFIB fusion gene is the result t(6;9)(q22-23;p23-24) translocation. Other MYB been...
Aims Radial sclerosing lesions (RSLs) are benign breast composed of glandular and epithelial proliferations with stellate architecture fibro‐elastotic stroma, which can mimic invasive carcinoma on imaging. Surgical management following a core biopsy diagnosis RSLs remains controversial. Methods results We retrospectively identified biopsies without atypia who underwent subsequent surgical excision between 2015 2021. All slides were reviewed to confirm the diagnosis. Imaging was determine...
Microglandular adenosis (MGA)-related lesions, including atypical MGA (AMGA) and carcinoma involving (C-MGA), are characterized by epithelial atypia, negative hormone receptors, HER2 status, can mimic invasive triple breast cancer (TNBC) in core needle biopsies (CNB) resulting selection for treatment with neoadjuvant chemotherapy (NAC). We identified 12 cases of AMGA and/or C-MGA post-NAC excision specimens (EXC) analyzed their morphologic immunohistochemical (IHC) features. All CNBs were...