A5102946664- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Advanced Breast Cancer Therapies
- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Cancer and Skin Lesions
- Breast Implant and Reconstruction
- Estrogen and related hormone effects
- BRCA gene mutations in cancer
- Cancer Treatment and Pharmacology
- Metastasis and carcinoma case studies
- Ovarian cancer diagnosis and treatment
- Prostate Cancer Treatment and Research
- Soft tissue tumor case studies
- Genetic factors in colorectal cancer
- Medical Imaging Techniques and Applications
- PARP inhibition in cancer therapy
- Radiomics and Machine Learning in Medical Imaging
- Reconstructive Surgery and Microvascular Techniques
- Single-cell and spatial transcriptomics
- Cancer Diagnosis and Treatment
- Endometriosis Research and Treatment
- Peptidase Inhibition and Analysis
- MRI in cancer diagnosis
Heinrich Heine University Düsseldorf
2016-2025
Düsseldorf University Hospital
2016-2025
Klinik für Frauenheilkunde
2008-2024
University Hospital Schleswig-Holstein
2022
University of Lübeck
2022
Universitäts Frauenklinik
2010-2021
Ludwig-Maximilians-Universität München
2016-2019
National Center for Tumor Diseases
2019
University Hospital Heidelberg
2016-2019
University of Oslo
2019
The nodal burden of patients with residual isolated tumor cells (ITCs) in the sentinel lymph nodes (SLNs) after neoadjuvant chemotherapy (NAC) (ypN0i+) is unknown, and axillary management not standardized. We investigated rates additional positive (LNs) at node dissection (ALND) oncologic outcomes ypN0i+ treated without ALND.
Das axilläre Staging bildet einen integralen Bestandteil in der chirurgischen Behandlung des frühen Mammakarzinoms. Hier stellt bei Patientinnen mit initial klinisch und sonographisch unauffälligen Lymphknoten (cN0) die Sentinel-Lymphonodektomie (SLNE) sowohl primär geplanter Operation als auch nach Neoadjuvanz den Goldstandard dar. Nach Publikation ACOSOG-Z011-Studie wird cN0-Patientinnen primärer brusterhaltender Therapie Bestrahlung postoperativ bis zu 2 befallenen Sentinel-Lymphknoten...
Background/Objectives: This single-center analysis evaluated the number of potential candidates for endocrine-based oral maintenance therapy in a real-world setting, focusing on three therapeutic agents, namely, olaparib, abemaciclib, and ribociclib, patients with hormone receptor-positive HER2-negative early breast cancer. Methods: All cancer cases from past 10 years (n = 3230) that underwent treatment at certified Breast Cancer Center Department Gynecology Obstetrics, University Hospital...
The trinational survey project conducted by the Young Forums of German, Austrian, and Swiss Societies for Gynecology Obstetrics aims to assess preferences prospective practicing gynecologists regarding various work-time models, compatibility family career, as well parental leave. Between October 2023 May 2024, a total 1364 participants took part in survey. questionnaire consisted 62 questions covering topics such workplace general, training priorities, team compositions, professional goals....
Abstract Purpose The use of autologous tissues is considered gold standard for patients undergoing breast reconstruction and the preferred method in post-radiation setting. Although latissimus dorsi flap (LDF) has been replaced by abdominal flaps as technique choice, it remains a valuable option several specific clinical situations its regaining popularity recent years. In this work, we present an 18-year retrospective analysis single-institution single-surgeon experience with LDF-based...
Pseudoangiomatous stromal hyperplasia (PASH) is a benign proliferation of mammary stroma mostly described as an incidental microscopic finding. Clinically, it can manifest palpable, well-circumscribed breast mass or in rare cases diffuse bilateral process causing massive enlargement. The most postulated theory for aetiology this condition hormonal stimulation myofibroblasts, particularly by progesterone. A definite diagnosis PASH based on typical pathological findings like and empty...
In recent years, the blood-based analysis of circulating tumour cells (CTCs) and nucleic acids (DNA/RNA), otherwise known as liquid biopsy, has become increasingly important in breast cancer. Numerous trials have already underscored high prognostic significance CTC detection both early metastatic stages. Moreover, changes levels DNA (ctDNA) during course disease correlate with response to treatment. Research currently focuses on liquid-biopsy based therapeutic interventions this context,...
Abstract Purpose In the last 2 decades, optimal management of axilla in breast cancer patients receiving neoadjuvant chemotherapy (NACT) has been one most frequently discussed topics. Little is known about attitudes surgeons/radiologists towards new developments such as targeted axillary dissection. Therefore, NOGGO conducted a survey to evaluate current approach management. Methods A standardized digital questionnaire was sent out > 200 departments Germany between 7/2021 and 5/2022. The...
The question of how to deal with B3 lesions is emerging interest.In the breast diagnostics 192 patients between 2009 and 2016, a minimally invasive biopsy revealed lesion subsequent resection. This study investigates malignancy rate different subgroups risk factors that play role in obtaining malignant finding.The distribution after was as follows: atypical ductal hyperplasia (ADH), 7.3%; flat epithelial atypia (FEA), 7.8%; lobular neoplasia (LN), papilloma (Pa), 49.5%; phylloidal tumour...
Breast cancer (BC) in men represents between 0.5% and 1% of all BC diagnosed each year. We report a case advanced 62-year-old male treated at our interdisciplinary Cancer Center. The patient presented with newly large, symptomatic mass his left breast. Clinical examination showed not movable 16 cm diameter, deforming the whole breast; overlying skin was livid hypervascularized. Enlarged lymph nodes were palpable axillary pit. He had no concomitant diseases time presentation. denied any...
Introduction Invasive breast cancer with neuroendocrine differentiation is a rare subtype of malignancy. Due to frequent changes in the definition these lesions, correct diagnosis, estimation exact prevalence, and clinical behaviour this entity may be challenging. The aim study was evaluate features, outcomes large cohort patients differentiation. Patients Twenty-seven cases have been included analysis. Twenty-one were identified by systematic immunohistochemical re-evaluation 465 specimens...
Abstract Background: Metastatic breast cancer (MBC) is an incurable disease and both the improvement of survival maintenance quality life (QoL) are equally important aims treatment planning. In patients with HER2-positive MBC, taxane-based chemotherapy in combination dual HER2 targeted therapy trastuzumab (T) pertuzumab (P) standard care first line therapy. However, adverse events well-known side effects any cytostatic can seriously impact patients’ QoL. addition, MBC activated estrogen...
Abstract Introduction As early breast cancer might relapse even after complete removal of and lymphnodes, the disease must persist in secondary sites. The detection disseminated tumor cells (DTC) bone marrow (BM) has been described as a surrogate residual disease. Various trials showed an impaired prognosis DTC positive (EBC) patients. PADDY (Pooled Analysis Detection Early Breast Cancer) study is large international pooled analysis that aimed to assess prognostic impact patients with EBC....