A5071496074- Breast Cancer Treatment Studies
- Cancer, Hypoxia, and Metabolism
- Breast Lesions and Carcinomas
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Breast Implant and Reconstruction
- TGF-β signaling in diseases
- MRI in cancer diagnosis
- HER2/EGFR in Cancer Research
- Cervical Cancer and HPV Research
- Lymphatic System and Diseases
- Cancer and Skin Lesions
- Sarcoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cancer Treatment and Pharmacology
- Radiopharmaceutical Chemistry and Applications
- Estrogen and related hormone effects
- Neuroendocrine Tumor Research Advances
- Advanced MRI Techniques and Applications
- Advanced X-ray Imaging Techniques
- Cancer-related Molecular Pathways
- Lung Cancer Research Studies
- Medical Imaging and Pathology Studies
- Radiomics and Machine Learning in Medical Imaging
- Advanced Breast Cancer Therapies
Kantonsspital Baden
2016-2025
Breast Center
2017-2025
University Hospital of Zurich
2010-2013
Universitäts Frauenklinik
2005-2011
Leipzig University
2004-2009
Yale University
2006
Abstract Hypoxia is now established as a key factor influencing the pathophysiology of malignant growth. Among other effects, hypoxia modulates expression multitude genes through induction hypoxia-inducible transcription factors. This differential gene favors angiogenesis, cell survival, an invasive/metastatic phenotype, and resistance to anticancer therapies. Because benign tumors do not exhibit these traits, one might expect entities be neither hypoxic nor induce genetic response program....
Grating-interferometry-based mammography (GIM) might facilitate breast cancer detection, as several research works have demonstrated in a pre-clinical setting, since it is able to provide attenuation, differential phase contrast, and scattering images simultaneously. In order translate this technique the clinics, has be adapted cover large field-of-view within clinically acceptable exposure time radiation dose.We set up grating interferometer that fits into standard system fulfilled...
We developed tailored axillary surgery (TAS) to reduce the tumor volume in patients with clinically node-positive breast cancer point where radiotherapy can control it. The aim of this study was quantify extent load reduction achieved by TAS.
Importance The role of axillary lymph node dissection (ALND) to determine nodal burden inform systemic therapy recommendations in patients with clinically (cN)–positive breast cancer (BC) is currently unknown. Objective To address the association ALND cN-positive BC upfront surgery setting and after neoadjuvant chemotherapy (NACT). Design, Setting, Participants This was a prospective, observational, cohort study conducted from August 2018 June 2022. preplanned within phase 3 randomized...
Refraction-based x-ray imaging can overcome the fundamental contrast limit of computed tomography (CT), particularly in soft tissue, but so far has been constrained to high-dose ex vivo applications or required highly coherent sources, such as synchrotrons. Here we demonstrate that grating interferometry (GI) is more dose efficient than conventional CT human breast under close-to-clinical conditions. Our system, based on a source and commercial gratings, outperformed for spatial resolutions...
Abstract Background: In patients with micro- and macrometastases in the sentinel lymph node (SLN) after neoadjuvant chemotherapy (NAC), additional positive nodes are found >60% of cases axillary dissection (ALND) is currently considered standard care. The likelihood finding residual isolated tumor cells (ITCs) unknown, benefit ALND unclear. As a consequence, surgical management axilla these not standardized. We sought to evaluate how often found, determine factors associated ALND,...
Non-mass enhancement (NME) in breast MRI is the most common feature of ductal carcinoma situ (DCIS). We sought to evaluate interobserver variability and positive predictive value (PPV) for malignancy NME descriptors using fifth edition BI-RADS lexicon focusing on newly introduced "clustered ring enhancement" pattern.Breast MRIs 129 patients who had undergone MRI-guided vacuum-assisted biopsy (VAB) our institution were reviewed. Studies assessed as classified according by two radiologists....
The nodal burden of patients with residual isolated tumor cells (ITCs) in the sentinel lymph nodes (SLNs) after neoadjuvant chemotherapy (NAC) (ypN0i+) is unknown, and axillary management not standardized. We investigated rates additional positive (LNs) at node dissection (ALND) oncologic outcomes ypN0i+ treated without ALND.
Introduction Up to one-fifth of breast cancer survivors will develop chronic cancer-related lymphoedema (BCRL). To date, complex physical decongestion therapy (CDT) is the gold standard treatment. However, it mainly symptomatic and often ineffective in preventing BCRL progression. Lymphovenous anastomosis (LVA) vascularised lymph node transfer (VLNT) are microsurgical techniques that aim restore lymphatic drainage. This international randomised trial aims evaluate advantages interventions...
Hypoxia inducible factor-1alpha (HIF-1alpha) has been proposed as a candidate endogenous marker of tumor hypoxia and molecular mediator hypoxia-driven malignant progression acquired treatment resistance. In this study, HIF-1alpha expression in 68 biopsies oxygenation measurement tracks from squamous cell carcinomas the uterine cervix 38 patients was assessed. Expression commonly found to increase function distance microvessels, at center aggregations, vicinity necrotic areas. However, there...
Several classification systems are available to assess pathological response neoadjuvant chemotherapy in breast cancer, but reliable biomarkers predict the efficiency of primary systemic therapy (PST) still missing. Deregulation gap junction channel forming connexins (Cx) has been implicated carcinogenesis and tumour progression through loss cell cycle control. In this study we correlated Cx expression proliferation with disease survival cancers using existing systems.The Cx26, Cx32, Cx43,...
Summary: Small cell carcinomas (SmCCs) of the uterine cervix are rare tumors. The knowledge regarding protein expression several checkpoint candidates cycle regulation is limited. Surgically treated SmCCs were selected from our files for immunohistochemical staining (neuroendocrine markers, p53, p16, p14, and cyclin D1). Polymerase chain reaction analysis, using general primers, was performed human papillomavirus analysis. Nine 677 tumors (1.3%) classified as after Grimelius (8/9 positive)...
In Switzerland, the French-speaking region has an organized breast cancer (BC) screening program; in German-speaking region, only opportunistic until recently had been offered. We evaluated factors associated with attendance to these two regions. analyzed data of 50–69 year-old women (n = 2769) from Swiss Health Survey 2012. Factors interest included education level, place residence, nationality, marital status, smoking history, alcohol consumption, physical activity, diet, self-perceived...
Abstract Purpose: Physiologically, hypoxia induces the expression of erythropoietin (Epo) in adult kidney cells. Epo, turn, acts on Epo receptor (EpoR) RBC precursors to stimulate growth and prevent apoptosis. Because plays a major role malignant progression tumors its receptors have also been detected tumors, we investigated EpoR their relationship with hypoxia, proliferation, apoptosis, clinicopathologic variables cervical cancer. Experimental Design: Intratumoral oxygen measurement needle...
Breast cancer is the most common in women worldwide and solid tumor type for which highest number of drugs have been approved to date. This study examines new drug approvals breast by United States Food Drug Administration (FDA) European Medicines Agency (EMA), based on an analysis regulatory documents from both agencies period 1995 2018. Of 29 over this time span, 17 received positive decisions FDA EMA, including all licensed after 2008. Nineteen 25 FDA-approved drugs, but none EMA...
Abstract Objectives Augmented reality (AR), which entails overlay of in situ images onto the anatomy, may be a promising technique for assisting image-guided interventions. The purpose this study was to investigate and compare learning experience performance untrained operators puncture soft tissue lesions, when using AR ultrasound (AR US) compared with standard US (sUS). Methods Forty-four medical students (28 women, 16 men) who had completed basic course, but no US, were asked perform...