A5080183722- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- Cancer and Skin Lesions
- BRCA gene mutations in cancer
- Cancer Immunotherapy and Biomarkers
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- AI in cancer detection
- Male Breast Health Studies
- Advanced Breast Cancer Therapies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Treatment and Pharmacology
- DNA Repair Mechanisms
- Metastasis and carcinoma case studies
- Brain Metastases and Treatment
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- Monoclonal and Polyclonal Antibodies Research
- Angiogenesis and VEGF in Cancer
- Multiple and Secondary Primary Cancers
- Immunotherapy and Immune Responses
Memorial Sloan Kettering Cancer Center
2016-2025
Kettering University
2009-2024
Cornell University
2009-2023
Memorial Hospital
2016-2023
University of Turin
2018-2019
University Hospital of Basel
2019
Candiolo Cancer Institute
2019
Institut Curie
2017-2019
University of Basel
2018
University of Bologna
2018
Vascular endothelial growth factor (VEGF) is a heparin-binding, cell-specific mitogen. Previous studies have suggested that VEGF regulator of naturally occurring physiologic and pathologic angiogenesis. In this study we investigated the hypothesis angiogenic potential sufficient to constitute therapeutic effect. The soluble 165-amino acid isoform was administered as single intra-arterial bolus internal iliac artery rabbits in which ipsilateral femoral excised induce severe, unilateral hind...
The classification of breast tumours continues to evolve, with the integration new knowledge from research rapidly being translated into clinical practice. Major changes are shown in Table 1. In this volume World Health Organization (WHO) series’ fifth edition, which is an update fourth-edition published 2012,1 descriptions follow familiar systematic approach previous volumes, content now organised sequence benign epithelial proliferations and precursors, through neoplasms, in-situ invasive...
BACKGROUND Hypoxia and indirect angiogenic factors may stimulate angiogenesis via induction of endothelial cell mitogen(s). To evaluate this hypothesis, we investigated whether low oxygen tension or cytokines known to promote neovascularization in vivo could modulate the expression either vascular growth factor (VEGF) basic fibroblast (bFGF) human smooth muscle cells (SMCs). METHODS AND RESULTS SMCs were treated with platelet-derived BB (PDGF-BB) transforming factor-beta 1 (TGF-beta 1)...
Genome-wide analyses have identified thousands of long noncoding RNAs (lncRNAs). Malat1 ( metastasis-associated lung adenocarcinoma transcript 1 ) is among the most abundant lncRNAs whose expression altered in numerous cancers. Here we report that genetic loss or systemic knockdown using antisense oligonucleotides (ASOs) MMTV mouse mammary tumor virus -PyMT carcinoma model results slower growth accompanied by significant differentiation into cystic tumors and a reduction metastasis....
The microenvironment is known to critically modulate tumor progression, yet its role in regulating treatment response poorly understood. Here we found increased macrophage infiltration and cathepsin protease levels mammary tumors following paclitaxel (Taxol) chemotherapy. Cathepsin-expressing macrophages protected against Taxol-induced cell death coculture, an effect fully reversed by inhibition mediated partially cathepsins B S. Macrophages were also protect induced additional...
Smooth muscle cells, macrophages, glial keratinocytes, and transformed cells have been established as synthesis sites for vascular endothelial growth factor (VEGF). The modulating effects of VEGF are essentially limited to (ECs), the only cell type consistently shown express receptors. has thus considered act exclusively via a paracrine pathway. We sought determine whether role human ECs might, under selected conditions, extend beyond that target involve contingency VEGF. In both...
Obesity is a risk factor for the development of hormone receptor-positive breast cancer in postmenopausal women and has been associated with an increased recurrence reduced survival. In humans, obesity causes subclinical inflammation visceral subcutaneous adipose tissue, characterized by necrotic adipocytes surrounded macrophages forming crown-like structures (CLS). Recently, we found numbers CLS, activation NF-κB transcription factor, elevated aromatase levels activity mammary glands obese...
Purpose While the mortality associated with ductal carcinoma in situ (DCIS) is minimal, risk of ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery (BCS) relatively high. Radiation therapy (RT) and antiestrogen agents reduce IBTR are considered standard treatment options BCS. However, they have never been proven to improve survival, themselves carry rare but serious risks. Individualized estimation would assist decision making regarding various for women DCIS. Patients...
ID genes are required for breast cancer colonization of the lungs, but mechanism remains poorly understood. Here, we show that Id1 expression induces a stem-like phenotype in cells while retaining epithelial properties, contrary to notion properties inextricably linked mesenchymal state. During metastatic colonization, mesenchymal-to-epithelial transition (MET), specifically whose state is dependent on target protein Twist1, not at primary site, where this controlled by zinc finger Snail1....