A5080086897- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Acute Myeloid Leukemia Research
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Hematopoietic Stem Cell Transplantation
- Anorectal Disease Treatments and Outcomes
- S100 Proteins and Annexins
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
- Bacterial Infections and Vaccines
- Reproductive tract infections research
- Immunotherapy and Immune Responses
- Glioma Diagnosis and Treatment
- Diabetes Management and Research
- Monoclonal and Polyclonal Antibodies Research
- Histone Deacetylase Inhibitors Research
- Hepatitis C virus research
- Connective tissue disorders research
- Infant Nutrition and Health
- Reproductive System and Pregnancy
- Spondyloarthritis Studies and Treatments
- Cancer Risks and Factors
- Cancer, Hypoxia, and Metabolism
- Hepatitis B Virus Studies
Columbia University
2020-2024
Mayo Clinic
2024
Broad Center
2021
University of California, San Francisco
2021
New York Stem Cell Foundation
2020
Memorial Sloan Kettering Cancer Center
2012-2017
University of Lausanne
2017
Ludwig Cancer Research
2017
Cancer Genetics (United States)
2011
Stanford University
2008
The microenvironment is known to critically modulate tumor progression, yet its role in regulating treatment response poorly understood. Here we found increased macrophage infiltration and cathepsin protease levels mammary tumors following paclitaxel (Taxol) chemotherapy. Cathepsin-expressing macrophages protected against Taxol-induced cell death coculture, an effect fully reversed by inhibition mediated partially cathepsins B S. Macrophages were also protect induced additional...
Abstract Tumor relapse after chemotherapy-induced regression is a major clinical problem, because it often involves inoperable metastatic disease. Tumor-associated macrophages (TAM) are known to limit the cytotoxic effects of chemotherapy in preclinical models cancer. Here, we report that an alternatively activated (M2) subpopulation TAMs (MRC1+TIE2HiCXCR4Hi) accumulate around blood vessels tumors chemotherapy, where they promote tumor revascularization and relapse, part, via VEGF-A release....
Antimitotic agents, including Taxol, disrupt microtubule dynamics and cause a protracted mitotic arrest subsequent cell death. Despite the broad utility of these drugs in breast cancer other tumor types, clinical response remains variable. Tumor-associated macrophages (TAMs) suppress duration Taxol-induced cells promote earlier slippage. This correlates with decrease phosphorylated form histone H2AX (γH2AX), decreased p53 activation, reduced death interphase. TAMs viability following...
Abstract Perineural invasion (PNI) is an ominous event strongly linked to poor clinical outcome. Cells residing within peripheral nerves collaborate with cancer cells enable PNI, but the contributing conditions tumor microenvironment are not well understood. Here, we show that CCR2-expressing inflammatory monocytes (IM) preferentially recruited sites of where they differentiate into macrophages and potentiate nerve through a cathepsin B–mediated process. A series adoptive transfer...
Obesity-associated inflammation promotes tumor growth and metastatic spread
Development of a successful hepatitis C virus (HCV) vaccine requires the definition neutralization epitopes that are conserved among different HCV genotypes. Five human monoclonal antibodies (HMAbs) described cross-compete with other to cluster overlapping epitopes, previously designated domain B. Each HMAb broadly neutralizes retroviral pseudotype particles expressing E1 and E2 glycoproteins, as well infectious chimeric genotype 1a 2a viruses. Alanine substitutions residues within region...
Deregulated cathepsin proteolysis occurs across numerous cancers, but in vivo substrates mediating tumorigenesis remain ill-defined. Applying 8-plex iTRAQ terminal amine isotopic labeling of (TAILS), a systems-level N-terminome degradomics approach, we identified B, H, L, S, and Z cleavage sites with the use six different knockout genotypes Rip1-Tag2 mouse model pancreatic neuroendocrine tumorigenesis. Among 1,935 proteins 1,114 N termini by TAILS, stable proteolytic products were wild-type...
Hematopoietic stem cells (HSC) and downstream lineage-biased multipotent progenitors (MPP) tailor blood production control myelopoiesis on demand. Recent lineage tracing analyses revealed MPPs to be major functional contributors steady-state hematopoiesis. However, we still lack a precise resolution of myeloid differentiation trajectories cellular heterogeneity in the MPP compartment. Here, found that myeloid-biased MPP3 are functionally molecularly heterogeneous, with distinct subset...
ABSTRACT A challenge in hepatitis C virus (HCV) vaccine development is defining conserved protective epitopes. cluster of these epitopes comprises an immunodominant domain on the E2 glycoprotein, designated B. CBH-2 a neutralizing human monoclonal antibody to B epitope that highly conserved. Alanine scanning demonstrated involves residues G523, G530, and D535 are also contact for binding CD81, coreceptor required entry into cells. However, another residue, located at position 431 thus...
Until a uniform classification system is adopted, it will be hard to compare studies of football injuries. This author believes that the picture not as grim often reported.
An oncogenic splice variant of the transcription factor KLF6 is associated with metastasis and poor survival in node-negative breast cancer patients promotes epithelial-to-mesenchymal transition by regulating Twist.