A5034045594- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
- Advanced Breast Cancer Therapies
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Neuroblastoma Research and Treatments
- Histone Deacetylase Inhibitors Research
- PARP inhibition in cancer therapy
- Epigenetics and DNA Methylation
- Melanoma and MAPK Pathways
- Cancer-related gene regulation
- Computational Drug Discovery Methods
- Circular RNAs in diseases
- Chemical Reactions and Isotopes
- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Biochemical and Molecular Research
- Single-cell and spatial transcriptomics
- Extracellular vesicles in disease
Rockefeller University
2015-2025
Memorial Sloan Kettering Cancer Center
2011-2024
Center for Systems Biology
2014
New York Proton Center
2014
Cancer Genetics (United States)
2008
Harvard University
1997-2005
Boston University
2000
University of Utah
1997
Harvard–MIT Division of Health Sciences and Technology
1997
Post-transcriptional regulators have emerged as robust effectors of metastasis and display deregulated expression through unknown mechanisms. Here, we reveal that the human microRNA-335 locus undergoes genetic deletion epigenetic promoter hypermethylation in every metastatic derivative obtained from independent patients’ malignant cell populations. Genetic miR-335 is a common event breast cancer, enriched for cancer metastases, also correlates with ovarian recurrence. We furthermore identify...
Abstract Individual cells within a tumour can exhibit distinct genetic and molecular features. The impact of such diversification on metastatic potential is unknown. Here we identify clonal human breast cancer subpopulations that display different levels morphological diversity. Highly variable are more proficient at colonization chemotherapeutic survival. Through single-cell RNA-sequencing, inter-cell transcript expression variability identified as defining feature the highly leads to...
Article30 November 2015Open Access PTPRN2 and PLCβ1 promote metastatic breast cancer cell migration through PI(4,5)P2-dependent actin remodeling Caitlin A Sengelaub Laboratory of Systems Cancer Biology, Rockefeller University, New York, NY, USA Search for more papers by this author Kristina Navrazhina Jason B Ross Nils Halberg Sohail F Tavazoie Corresponding Author Information Sengelaub1, Navrazhina1, Ross1, Halberg1 1 1Laboratory *Corresponding author. Tel: +1 212 327 208; Fax: 7209;...