A5069648214- Reconstructive Surgery and Microvascular Techniques
- Epigenetics and DNA Methylation
- Breast Implant and Reconstruction
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Breast Cancer Treatment Studies
- Organ and Tissue Transplantation Research
- Digital Imaging in Medicine
- Cancer Mechanisms and Therapy
- Lymphatic System and Diseases
- Surgical Sutures and Adhesives
- Laser Applications in Dentistry and Medicine
- Cancer survivorship and care
- S100 Proteins and Annexins
- Mast cells and histamine
- Angiogenesis and VEGF in Cancer
- Reconstructive Facial Surgery Techniques
- Artificial Intelligence in Healthcare and Education
- Mesenchymal stem cell research
- interferon and immune responses
- Electromagnetic Fields and Biological Effects
- Sympathectomy and Hyperhidrosis Treatments
- Nasolacrimal Duct Obstruction Treatments
Brigham and Women's Hospital
2019-2025
Harvard University
2017-2025
Freeman Hospital
2024
University of Arkansas for Medical Sciences
2017-2023
Massachusetts General Hospital
2020
Musculoskeletal Transplant Foundation
2019
Columbia University Irving Medical Center
2013-2018
NewYork–Presbyterian Hospital
2013-2018
Beth Israel Deaconess Medical Center
2017
Rush University
2017
Learning Objectives: After reading this article, the participant should be able to: 1. Understand indications for implant-based breast reconstruction and nipple preservation compared to skin-sparing or skin-reducing patterns. 2. direct-to-implant versus tissue expander/implant advantages disadvantages of total, partial, no muscle coverage. 3. role acellular dermal matrix mesh in reconstruction. 4. Learn different types styles implants develop a postoperative plan care pain management....
Abstract Modulation of the immune system can produce anti-tumor responses in various cancer types, including melanoma. Recently, checkpoint inhibitors (ICI), single agent and combination regimens, have produced durable long-lasting clinical a subset metastatic melanoma patients. These monoclonal antibodies, developed against CTLA-4 PD-1, block immune-inhibitory receptors on activated T-cells, amplifying response. However, even when using anti-CTLA-4 anti-PD-1 combination, approximately half...
Abstract Identifying controlling features of responsiveness to checkpoint blockade therapies is an urgent goal in oncology research. Our group and others have previously shown melanoma tumors resistant display mesenchymal transition, including E-cadherin loss. Here, we present the first vivo evidence that from tumor cells facilitate immune attack, using a B16F10 mouse model which exogenously expressed (B16.Ecad). We find, compared with vector control, B16.Ecad exhibits delayed growth,...
The prevalence of smoking, at-risk alcohol use, overweight/obesity, inadequate fruit and vegetable consumption, physical activity was examined among homeless adults. Desire to change these modifiable health risk factors the association between desire self-rated also were examined.A sample 394 adults completed computer-based questionnaires (read over headphones) that assessed sociodemographic characteristics, factors, address health.Participants primarily men (71.8%) African Americans...
Introduction Up to one-fifth of breast cancer survivors will develop chronic cancer-related lymphoedema (BCRL). To date, complex physical decongestion therapy (CDT) is the gold standard treatment. However, it mainly symptomatic and often ineffective in preventing BCRL progression. Lymphovenous anastomosis (LVA) vascularised lymph node transfer (VLNT) are microsurgical techniques that aim restore lymphatic drainage. This international randomised trial aims evaluate advantages interventions...
Vaccine adjuvants have been reported to induce both mucosal and systemic immunity when applied surfaces this dual response appears important for protection against certain pathogens. Despite the potential advantages, however, no are currently approved human use. Evaluating compounds as is a slow costly process due need lengthy animal immunogenicity studies. We constructed library of 112 intranasal adjuvant candidate formulations consisting oil-in-water nanoemulsions that contain various...
Fifty children who underwent day case herniotomy received either a caudal injection of 1 ml/kg bupivacaine 0.25% or infiltration the wound edges at end surgery with 0.5 0.25%, allocated random. Postoperative pain and demeanour were assessed initially by an observer later use parental questionnaire. Wound local anaesthetic solution provided analgesia which was comparable to that associated block, incidence side effects similar in two groups. offers simple, safe alternative block for provision...
Background: This article discusses the senior author’s (M.T.) experience with nipple-areola complex malposition following nipple-sparing mastectomy, surgical options for treatment, and an analysis of risk factors. Methods: A retrospective review was conducted on a prospectively collected institutional board–approved database mastectomy cases immediate device-based reconstruction performed between July 2006 October 2012. Malposition graded as mild (1 cm), moderate (2 or severe (>3 cm)...
Pulsed electromagnetic fields have been shown to reduce postoperative pain, inflammation, and narcotic requirements after breast reduction augmentation surgical procedures. This study examined whether pulsed field therapy could produce similar results in patients undergoing unilateral transverse rectus abdominis myocutaneous (TRAM) flap reconstruction, a significantly more complex painful procedure.In this double-blind, placebo-controlled, randomized study, 32 TRAM reconstruction received...
T-cell exhaustion in cancer is linked to poor clinical outcomes, where evidence suggests metabolic changes precede functional exhaustion. Direct competition between tumor-infiltrating lymphocytes (TIL) and cells for resources often renders T dysfunctional. Environmental stress produces epigenome remodeling events within TIL resulting from loss of the histone methyltransferase EZH2. Here, we report an epigenetic mechanism contributing development TIL. A multiomics approach revealed a...
Background Three-dimensional (3D) printing has developed as a revolutionary technology with the capacity to design accurate physical models in preoperative planning. We present our experience surgeon-based of 3D models, using home software and for use an adjunct vascularized bone transfer. Methods Home techniques were used execution flap transfers upper extremity. Open source imaging was convert computed tomography scans create models. These printed surgeon's office planned reconstruction....
Glutamatergic synaptic transmission is terminated by members of the excitatory amino acid transporter (EAAT) family proteins that remove glutamate from cleft transporting it into surrounding glial cells. Recent structures a bacterial homolog suggest major motions within transmembrane domain translocate substrate across membrane. However, events leading to this large structural rearrangement are much less clear. Two reentrant loops have been proposed act as extracellular and intracellular...
Traditional free flap reconstruction of complex intraoral defects often uses large lip-splitting incisions. To reduce morbidity and preserve aesthetics, we have adopted a more technically demanding visor technique obviating an incision through the lower lip which resection are performed.A retrospective review was performed patients who underwent over 7 years by single plastic surgeon (C.H.R.) at institution. Patients were included if they from mandible, tongue, or floor mouth followed tissue...
Overexpression of S100B is routinely used for disease-staging and determining prognostic outcomes in patients with malignant melanoma. Intracellular interactions between wild-type (WT)-p53 have been demonstrated to limit the availability free WT-p53 tumor cells, inhibiting apoptotic signaling cascade. Herein, we demonstrate that, while oncogenic overexpression poorly correlated (R < 0.3; p > 0.05) alterations copy number or DNA methylation primary patient samples, transcriptional start...
Orthograde and retrograde endoscopy of the upper lower nasolacrimal system was performed using two prototype ultrathin (0.5 mm 1.1 diameter) fibrescopes on four cadaver heads. Appearances were verified by subsequent dissection. The procedure, which we term 9dacryocystoscopy9 is described. With modifications this technique may have clinical applications in treatment disorders.
Use of vasopressors is controversial in patients undergoing free flap reconstruction. Recent literature has suggested that it safe to administer intraoperatively during these procedures. However studies have not addressed whether this safety extends continuous high dose use. We present two cases who underwent surgery for squamous cell carcinoma the pharyngeal region, requiring laryngopharyngectomy. Both had reconstruction with a anterolateral thigh (ALT) flap. The first required...
Abstract Melanoma brain metastases (MBM) portend a grim prognosis and can occur in up to 40% of melanoma patients. Genomic characterization has been previously carried out identify potential mutational drivers. However, date comprehensive multi-omics approach yet be used analyze metastases. In this case report, we present an unbiased proteogenomics analyses patient’s primary skin cancer three from distinct anatomic locations. We performed molecular profiling comprised targeted DNA panel full...