A5074585201- Sinusitis and nasal conditions
- Asthma and respiratory diseases
- Head and Neck Surgical Oncology
- Nasal Surgery and Airway Studies
- Allergic Rhinitis and Sensitization
- Olfactory and Sensory Function Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Meningioma and schwannoma management
- Mast cells and histamine
- Oral and Maxillofacial Pathology
- Drug-Induced Adverse Reactions
- IL-33, ST2, and ILC Pathways
- Cell Adhesion Molecules Research
- Biochemical Analysis and Sensing Techniques
- COVID-19 and healthcare impacts
- Occupational exposure and asthma
- Click Chemistry and Applications
- Respiratory and Cough-Related Research
- Mycobacterium research and diagnosis
- Healthcare Policy and Management
- Contact Dermatitis and Allergies
- Ophthalmology and Eye Disorders
- Otolaryngology and Infectious Diseases
- Vascular Malformations Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
Brigham and Women's Hospital
2017-2025
Harvard University
2016-2025
Dana-Farber Brigham Cancer Center
2020
Dana-Farber Cancer Institute
2020
Massachusetts Eye and Ear Infirmary
2016-2017
Albany Medical Center Hospital
2015
National Institute for Occupational Safety and Health
2000
Centers for Disease Control and Prevention
2000
Saint Louis University Hospital
1999
The olfactory neuroepithelium serves as a sensory organ for odors and forms part of the nasal mucosal barrier. Olfactory neurons are surrounded supported by epithelial cells. Among them, microvillous cells (MVCs) strategically positioned at apical surface, but their specific functions enigmatic, relationship to other specialized is unclear. Here, we establish that family MVCs comprises tuft ionocytes in both mice humans. Integrating analysis respiratory epithelia, define distinct receptor...
Objective Periostin is an extracellular matrix protein that elevated in the sinonasal tissues of patients with chronic rhinosinusitis (CRS). The purpose this study was to determine whether serum periostin could serve as a molecular biomarker nasal polyp burden disease. Study Design Prospective cohort study. Setting Academic medical center. Subjects and Methods Serum levels were measured by ELISA on blood samples collected from undergoing sinus surgery for CRS (n = 71), further stratified...
Mast cells (MCs) expressing a distinctive protease phenotype (MCTs) selectively expand within the epithelium of human mucosal tissues during type 2 (T2) inflammation. While MCTs are phenotypically distinct from subepithelial MCs (MCTCs), signals driving MCT differentiation and this subset's contribution to inflammation remain unexplored. Here, we have identified TGF-β as key driver transcriptome in nasal polyps. We found that short-term signaling alters MC cell surface receptor expression...
Objective Antibiotic use and chronic rhinosinusitis (CRS) have been independently associated with microbiome diversity depletion opportunistic infections. This study was undertaken to investigate whether antibiotic may be an unrecognized risk factor for developing CRS. Study Design Case‐control of 1,162 patients referred a tertiary sinus center range sinonasal disorders. Methods Patients diagnosed CRS according established consensus criteria (n = 410) were assigned the case group (273...
To describe cases that illustrate the utility of intraoperative computed tomography (CT) in cochlear implantation patients with difficult temporal bone anatomy.A 2-year-old male congenital X-linked stapes gusher syndrome and a female enlarged vestibular aqueduct underwent successful help CT. In latter case, initial C-arm fluoroscopy suggested malposition electrode, however, was not able to provide details for adjustments. both cases, CT changed insertion technique operating surgeon allowed...
Objectives/Hypothesis To evaluate the increase in access to maxillary sinus (MS) with transnasal endoscopic medial wall transposition (TEMMT), while preserving major structures of nasal cavity. Study Design The study was divided into three parts: anatomical, radiographic, and case series. Methods Three cadaveric dissections (total six sides) confirmed feasibility TEMMT approach. Radiographic measurements using maxillofacial computed tomography scans were taken assess maximal antrostomy....
Objectives This study aims to define the endoscopic anatomy of inferior intraconal space, in terms its neurovascular structures and relationship fixed anatomic landmarks. Design A cadaveric anatomical was conducted. Setting conducted at an academic cranial base center. Participants Cadaveric subjects have been investigated. Main Outcome Measures After dissection number position ophthalmic artery (OA) oculomotor nerve (OMN) branches rectus muscle (IRM) were quantified relative landmark...
Risk factors in adult patients with cystic fibrosis (CF) associated surgical intervention have not been delineated.To identify characteristics of CF and chronic rhinosinusitis that predict endoscopic sinus surgery (ESS).Patients were identified a tertiary center by the International Classification Diseases, Ninth Revision codes 277.00-277.03, which represent CF. Charts reviewed for transmembrane conductance regulator (CFTR) gene mutation, Lund-Mackay score (LMS), 22-item Sino-Nasal Outcome...
Objective/Hypothesis Angiotensin‐converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have been shown to suppress expression of periostin, a matricellular protein that is markedly elevated in nasal polyp tissue. The purpose this study was determine whether use these antihypertensive agents affects the time revision sinus surgery patients with regrowth. Study Design Case series chart review. Setting Academic medical center. Subjects Methods Records were reviewed for...
Abstract Objective Repair of cerebrospinal fluid (CSF) leaks the lateral recess sphenoid (LRS) sinus can be challenging to accomplish via an endoscopic transphenoidal approach. The transpterygoid approach improve surgical access but requires more extensive dissection. We review our experience with LRS CSF leak repair both techniques determine whether preoperative radiologic data help predict most appropriate Methods Electronic medical records patients were retrospectively reviewed at a...
Objective: To determine whether psychological status is an effect modifier of the previously observed low discriminatory capacity Sinonasal Outcome Test‐22 (SNOT‐22) scores for Lund‐Mackay computed tomography (CT) results. Study Design: Observational outcomes study. Setting: Tertiary care center. Subjects and Methods: We assessed patients presenting with chronic sinonasal complaints who underwent CT sinuses within 1 month completing SNOT‐22 instrument. overall domain were calculated, as...
Elevated IL-5, IL-13, IL-33, and CCL2 correlate with lower UPSIT scores in CRS AERD patients. TNF-α, CCL2, CXCL-8 higher SNOT-22
Objective The 22‐item Sinonasal Outcome Test (SNOT‐22) is a trusted measure of symptom severity in chronic rhinosinusitis. European Position Paper on Rhinosinusitis (EPOS) provides widely accepted diagnostic criteria, which include sinonasal symptoms, their duration, and imaging results. Our objective was to compare these approaches assessing symptoms determine if either more indicative radiologic findings, support decisions telehealth. Study Design Observational outcomes study. Setting...
The airway epithelium plays a central role in the pathogenesis of chronic respiratory diseases such as asthma and rhinosinusitis with nasal polyps (CRSwNP), but mechanisms by which epithelial cells (EpCs) maintain inflammation are poorly understood.
Objective To investigate the incidence and degree of contralateral sinus disease following treatment sinonasal malignancy (SNM) using radiological findings as an outcome measure. Study Design Retrospective case series. Setting Tertiary referral academic center. Participants Patients with SNM treated surgical adjuvant radiotherapy or without concurrent chemotherapy. Main Outcome Measures Pre- posttreatment computed tomography magnetic resonance imaging scans, Lund–Mackay (LM) score, date...
This study evaluated a National Institute for Occupational Safety and Health (NIOSH), Centers Disease Control Prevention, Alert concerning the risk prevention of latex allergy among health care workers. It has been estimated that 8-12% workers are sensitized to latex. NIOSH Alerts publications intended educate stakeholders about risks in workplace; this contained four recommendations administrative control measures hospital decision makers could adopt reduce employees. The was mailed random...
The airway epithelium plays a central role in the pathogenesis of chronic respiratory diseases such as asthma and rhinosinusitis with nasal polyps (CRSwNP). We hypothesized that transcriptomic assessment sorted epithelial cells (EpCs) could allow us to define mechanisms by which EpCs perpetuate inflammation.