A5009876913- Olfactory and Sensory Function Studies
- Allergic Rhinitis and Sensitization
- Sinusitis and nasal conditions
- Asthma and respiratory diseases
- Influenza Virus Research Studies
- Immune Response and Inflammation
- Advanced Chemical Sensor Technologies
- Emergency and Acute Care Studies
- Hospital Admissions and Outcomes
- Lipid Membrane Structure and Behavior
- Immune Cell Function and Interaction
- Biochemical Analysis and Sensing Techniques
- Voice and Speech Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Surgical Simulation and Training
- Pituitary Gland Disorders and Treatments
- Silk-based biomaterials and applications
- Inflammasome and immune disorders
- Eosinophilic Esophagitis
- Medical History and Innovations
- Air Quality and Health Impacts
- Ear Surgery and Otitis Media
- Barrier Structure and Function Studies
- Obstructive Sleep Apnea Research
- Neurobiology and Insect Physiology Research
Harvard University
2022-2025
Brigham and Women's Hospital
2022-2025
Ministry of Agriculture and Rural Affairs
2025
China Agricultural University
2025
Harbin Veterinary Research Institute
2021-2024
Chinese Academy of Agricultural Sciences
2021-2024
University of California, San Francisco
2022
State Key Laboratory of Veterinary Biotechnology
2021
The H7N9 influenza virus emerged in China 2013, causing more than 1560 human infections, 39% of which were fatal. A 'cytokine storm' the lungs patients has been linked to a poor prognosis and death; however, underlying mechanism that triggers cytokine storm is unknown. Here, we found efficient replication mouse activates gasdermin E (GSDME)-mediated pyroptosis alveolar epithelial cells, released cytosolic contents then trigger storm. Knockout Gsdme switched manner death A549 primary cells...
Influenza virus infection is initiated by the attachment of viral haemagglutinin (HA) protein to sialic acid receptors on host cell surface. Most particles enter cells through clathrin-mediated endocytosis (CME). However, it unclear how binding signals are transmitted plasma membrane triggering CME. Here we found that metabotropic glutamate receptor subtype 2 (mGluR2) and potassium calcium-activated channel subfamily M alpha 1 (KCa1.1) involved in initiation completion CME influenza using an...
Background Thymic stromal lymphopoietin (TSLP) plays an important role in mediating the type-2-inflammatory response. This study examined how TSLP and interleukin (IL)-4 levels patients with chronic rhinosinusitis nasal polyps (CRSwNP) correlated clinical postoperative outcomes. Methods Solid-phase sandwich ELISA was used to analyze IL-4 mucus (n = 47), plasma 17), polyp 30), inferior 25), middle 26) turbinate tissue collected during functional endoscopic sinus surgery (FESS) CRSwNP 76)...
Elevated IL-5, IL-13, IL-33, and CCL2 correlate with lower UPSIT scores in CRS AERD patients. TNF-α, CCL2, CXCL-8 higher SNOT-22
Currently, clinical assessment of olfaction is largely reliant on subjective methods that require patient participation. The objective method for measuring olfaction, using electroencephalogram (EEG) readings, can be supplemented with the improved temporal resolution magnetoencephalography (MEG) olfactory measurement delineate cortical and peripheral loss. MEG provides high spatial which enhance our understanding central processing compared to EEG alone.To determine feasibility building an...
To investigate the impact of SARS-CoV-2 on sinonasal quality life, olfaction, and cognition at different stages viral infection evaluate association between olfaction in this population cohort.While olfactory dysfunction (OD) is a frequently reported symptom COVID-19 (98% prevalence), neurocognitive symptoms are becoming more apparent as patients recover from infection. This study aims to address how [active (positive PCR test, symptomatic) vs. recovered (7 days post-symptoms)] compared...
Key points Decreased overall dietary consumption of micronutrients may be linked to an increased risk olfactory dysfunction (OD) including subjective report OD, phantosmia, and objective OD. Interactions were identified between these micronutrients, suggesting that outcomes vary depending on the mixture taken.
Medical illustration played a crucial, yet often overlooked, role in the evolution of pituitary surgery. From late 1800s to present, many preeminent surgeons, partnership with their surgical illustrator collaborators, developed and then shifted paradigm surgery, from an open procedure high mortality morbidity, endonasal approach success rates that is widely utilized today. This work aims highlight illustrators as partners physician colleagues, creating artistically accessible road maps...
Key Points IL‐5, CCL2, and CXCL8 in sinus mucous are higher patients with AERD relative to aspirin‐tolerant CRS These mediators pleiotropic, leading widescale inflammatory processes contributing is not only a T2 disease but heterogeneous: this may explain the refractory nature of