A5084890520- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neural Engineering
- Dental Anxiety and Anesthesia Techniques
- Hearing, Cochlea, Tinnitus, Genetics
- Opioid Use Disorder Treatment
- Nicotinic Acetylcholine Receptors Study
- Anesthesia and Pain Management
- Neurobiology and Insect Physiology Research
- Vestibular and auditory disorders
- Tracheal and airway disorders
- Esophageal and GI Pathology
- Dental Implant Techniques and Outcomes
- Orthopedic Infections and Treatments
- Acute Myeloid Leukemia Research
- Eosinophilic Disorders and Syndromes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Electrochemical Analysis and Applications
- Ear Surgery and Otitis Media
- Hearing Loss and Rehabilitation
- Hand Gesture Recognition Systems
- Congenital Diaphragmatic Hernia Studies
- Olfactory and Sensory Function Studies
University of Pittsburgh
2021-2025
University of Pittsburgh Medical Center
2023
Brown University
2017
National Institute of Neurological Disorders and Stroke
2017
National Institutes of Health
2017
Midbrain dopamine neurons recorded in vivo pause their firing response to reward omission and aversive stimuli. While the initiation of pauses typically involves synaptic or modulatory input, intrinsic membrane properties may also enhance limit hyperpolarization, raising question how conductances shape neurons. Using retrograde labeling electrophysiological techniques combined with computational modeling, we examined that evoked by current injections stimulation subpopulations grouped...
Currently, clinical assessment of olfaction is largely reliant on subjective methods that require patient participation. The objective method for measuring olfaction, using electroencephalogram (EEG) readings, can be supplemented with the improved temporal resolution magnetoencephalography (MEG) olfactory measurement delineate cortical and peripheral loss. MEG provides high spatial which enhance our understanding central processing compared to EEG alone.To determine feasibility building an...
Objective: To prospectively analyze pain and medication use following otologic surgery. Study Design: Prospective cohort study with patient reported logs logs. Setting: Tertiary academic hospital. Patients : Sixty adults who underwent outpatient surgeries. Interventions: Surveys detailing postoperative levels, nonopioid analgesic (NOA) use, opioid use. Main Outcome Measures: Self-reported scores, of NOA, medications normalized as milligrams morphine equivalents (MME). Results: Thirty-two...
Polycythemia vera (PV) is a myeloproliferative disease with overproduction of erythrocytes, leukocytes, and platelets causing an increased risk both thrombosis hemorrhage. There are limited reports no established guidelines for managing such patients undergoing reconstructive surgery.
To identify pore domain ligands on Kv7.2 potassium ion channels, we compared wild-type (WT) and W236L mutant channels in a series of assays with previously validated novel agonist chemotypes. Positive controls were retigabine, flupirtine, RL-81, channel activators that significantly shift voltage-dependent activation to more negative potentials (ΔV50) at 5 µM. We identified 6 new compounds exhibited differential enhancing activity between WT channels. Whole cell patch-clamp electrophysiology...