A5073233736- Organ and Tissue Transplantation Research
- Mesenchymal stem cell research
- Burn Injury Management and Outcomes
- Reconstructive Surgery and Microvascular Techniques
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- Organ Donation and Transplantation
- Electrospun Nanofibers in Biomedical Applications
- Transplantation: Methods and Outcomes
- Angiogenesis and VEGF in Cancer
- Hemoglobin structure and function
- Surgical Sutures and Adhesives
- Facial Rejuvenation and Surgery Techniques
- Injury Epidemiology and Prevention
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Nerve injury and regeneration
- Thermal Regulation in Medicine
- Cancer Cells and Metastasis
- Sepsis Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Blood transfusion and management
- Breast Cancer Treatment Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer Diagnosis and Treatment
University Hospital of Zurich
2016-2025
Kantonsspital Aarau
2021-2025
University of Zurich
2012-2025
Paracelsus Medizinische Privatuniversität
2023
Nuremberg Hospital
2023
University of Pittsburgh Medical Center
2015-2020
University of Pittsburgh
2013-2020
McGowan Institute for Regenerative Medicine
2015-2020
Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie
2019
See-Spital
2018
The aim of this study was to compare the effects goal-directed colloid fluid therapy with crystalloid and restricted on healthy perianastomotic colon tissue in a pig model anastomosis surgery.Pigs (n = 27, 9 per group) were anesthetized mechanically ventilated. A hand-sewn performed. animals subsequently randomized one following treatments: R-RL group, 3 ml x kg(-1) h(-1) Ringer lactate (RL); GD-RL RL + bolus 250 RL; GD-C hydroxyethyl starch (HES 6%, 130/0.4). administered when mixed venous...
Bromelain-based Enzymatic Debridement has been introduced as an additional concept to the burn surgeon's armamentarium and is best indicated for mid-to deep dermal burns with mixed patterns. Increasing evidence published focusing on special regions settings well limitations of improve patient care. To better guide in view increasing experience, there a need update formerly consensus guidelines user-orientated recommendations, which were last produced 2017. A multi-professional expert panel...
Eph receptor tyrosine kinases and their ligands (ephrins) are key players during the development of embryonic vasculature; however, role regulation in adult angiogenesis remain to be defined. Both receptors have been shown up-regulated a variety tumors. To address hypothesis that hypoxia is an important regulator Ephs/ephrins expression, we developed mouse skin flap model hypoxia. We demonstrate our truly represents segmental by applying four independent methods: continuous measurement...
In Brief Background Strategies aiming at minimization or elimination of systemic immunosuppression are key immediate goals for clinical expansion vascularized composite allotransplantation (VCA). We compared the in vitro and vivo immunomodulatory efficacy adipose-derived mesenchymal stem cells (AD-MSCs) bone marrow (BM)–derived MSCs a rat VCA model. Methods Both cell types were tested suppressor function using mixed lymphocyte reactivity assays. AD-MSCs BM-MSCs administered intravenously (1...
Vascularized composite allotransplantation opens new possibilities in reconstructive transplantation such as hand or face transplants. Lifelong immunosuppression and its side-effects are the main drawbacks of this procedure. Mesenchymal stem cells (MSCs) have clinically useful immunomodulatory effects may be able to reduce burden chronic immunosuppression. Herein, we assess compare characteristics capacities bone marrow- adipose tissue-derived MSCs isolated from same human individual across...
Stem cell-enriched fat grafting has been proposed as a potential therapy for reconstructive, restorative, or enhancement-related procedures of the breast. Its role in postoncologic breast reconstruction is still emerging, with concerns about safety. The authors investigated dose-dependent interaction between human adipose-derived mesenchymal stromal cells (AD-MSCs) and cancer cell (BCC) lines [MDA-MB-231 (MDA) MCF-7 (MCF)] focusing on tumor microenvironment, growth, metastatic...
Cellular therapies for immunomodulation in vascularized composite allotransplantation (VCA) have gained importance due to their potential minimization of immunosuppression. Adipose-derived (AD) mesenchymal stem cells (MSCs) especially shown encouraging potential. We investigated the influence timing and frequency AD-MSC treatment on immunologic graft survival as well vasculopathy outcomes after VCA.Lewis rats received full-mismatched Brown Norway rat hindlimb transplants. Recipient animals...
Abdominal wall reconstruction represents an ambitious and demanding challenge. This study aimed to illustrate the versatility of anterolateral thigh (ALT) flap in its different designs for complex defects abdominal wall. Charts patients with who underwent a ALT at University Hospital Zurich (2018-2020) were reviewed retrospectively. Patient characteristics flaps used analyzed detail. Ten received total 12 flaps. Free applied upper third abdomen. All harvested fascial component. An iliotibial...
Introduction Up to one-fifth of breast cancer survivors will develop chronic cancer-related lymphoedema (BCRL). To date, complex physical decongestion therapy (CDT) is the gold standard treatment. However, it mainly symptomatic and often ineffective in preventing BCRL progression. Lymphovenous anastomosis (LVA) vascularised lymph node transfer (VLNT) are microsurgical techniques that aim restore lymphatic drainage. This international randomised trial aims evaluate advantages interventions...
Cosmetic surgery tourism characterizes a phenomenon of people traveling abroad for aesthetic treatment. Problems arise when patients return with complications or need follow-up care.To investigate the cosmetic treated at our hospital as well to analyze arising costs health system.Between 2010 and 2014, we retrospectively included all presenting from abroad. We reviewed medical records patients' characteristics including performed operations, complications, Associated cost expenditure...
Face transplantation is a viable reconstructive approach for severe craniofacial defects. Despite the evolution witnessed in field, ethical aspects, clinical and psychosocial implications, public perception, economic sustainability remain subject of debate unanswered questions. Furthermore, poor data reporting sharing, absence standardized metrics outcome evaluation, lack consensus definitions success failure have hampered development "transplantation culture" on global scale. We completed...
Reconstructive transplantation has emerged as clinical reality over the past decade. Utilizing standard immunosuppressive drugs proven feasible in face and hand to achieve long-term graft acceptance. As vascularized composite tissue allotransplantation is not a life-saving procedure compared solid organ alternative protocols with less side effects are even more desirable. Allograft tolerance holy grail of many cell-based concepts recent data field most promising. Immunomodulation mesenchymal...
Local hypoxia, as due to trauma, surgery, or arterial occlusive disease, may severely jeopardize the survival of affected tissue and its wound-healing capacity. Initially developed replace blood transfusions, artificial oxygen carriers have emerged therapeutics in such conditions. The aim this study was target primary wound healing critically ischemic skin by systemic application left-shifted liposomal hemoglobin vesicles (HbVs). This tested bilateral, cranially based dorsal flaps mice...
The immunomodulatory potential of cell therapies using adipose-derived stem cells (ASCs) and bone marrow-derived mesenchymal (BM-MSCs) has been studied in vascularized composite allotransplantation (VCA). Most therapy-based experimental clinical protocols integrate some degree recipient conditioning/induction with antibodies or other immunosuppressive agents. We investigated the susceptibility ASCs BM-MSCs to anti-lymphocyte serum (ALS) tacrolimus. Rat were exposed varying concentrations...