A5087412483- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Ultrasound Imaging and Elastography
- RNA regulation and disease
- Ultrasound and Hyperthermia Applications
- Bone and Joint Diseases
- Peripheral Neuropathies and Disorders
- Brain Tumor Detection and Classification
- Systemic Lupus Erythematosus Research
- Medical Image Segmentation Techniques
- Migraine and Headache Studies
- Polyomavirus and related diseases
- Fetal and Pediatric Neurological Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Vestibular and auditory disorders
- Viral Infections and Immunology Research
- Cell Image Analysis Techniques
- MRI in cancer diagnosis
- Neurogenesis and neuroplasticity mechanisms
- Long-Term Effects of COVID-19
- Amyotrophic Lateral Sclerosis Research
- HIV Research and Treatment
- Neurogenetic and Muscular Disorders Research
University Hospital of Basel
2018-2025
University of Basel
2018-2025
University College London
2024
National Hospital for Neurology and Neurosurgery
2024
Universitat Autònoma de Barcelona
2024
Hospital Base
2020-2024
University Medical Center Freiburg
2024
University of Freiburg
2024
National Institute for Health Research
2024
Université de Lille
2024
Neuro-axonal injury is a key factor in the development of permanent disability multiple sclerosis. Neurofilament light chain peripheral blood has recently emerged as biofluid marker reflecting neuro-axonal damage this disease. We aimed at comparing serum neurofilament levels sclerosis and healthy controls, to determine their association with measures disease activity ability predict future clinical worsening well brain spinal cord volume loss. was measured by single molecule array assay 2183...
Neurofilament light chain (NfL) levels in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients correlate with degree neuronal injury. To date, little is known about NfL concentrations serum relapsing remitting (RRMS) and their relationship CSF magnetic resonance imaging (MRI) measures disease severity. We aimed to validate quantification samples RRMS, as a biofluid source easily accessible for longitudinal studies.A total 31 RRMS underwent sampling. After median time 3.6 years,...
Voxel-based morphometry from conventional T1-weighted images has proved effective to quantify Alzheimer's disease (AD) related brain atrophy and enable fairly accurate automated classification of AD patients, mild cognitive impaired patients (MCI) elderly controls. Little is known, however, about the power volume-based morphometry, where features interest consist a few structure volumes (e.g. hippocampi, lobes, ventricles) as opposed hundreds thousands voxel-wise gray matter concentrations....
White matter bundle segmentation using diffusion MRI fiber tractography has become the method of choice to identify white pathways in vivo human brains. However, like other analyses complex data, there is considerable variability protocols and techniques. This can result different reconstructions same intended pathways, which directly affects results, quantification, interpretation. In this study, we aim evaluate quantify that arises from for segmentation. Through an open call users...
There is a lack of validated biomarkers for disability progression independent relapse activity (PIRA) in multiple sclerosis (MS).
<h3>Importance</h3> The mechanisms driving neurodegeneration and brain atrophy in relapsing multiple sclerosis (RMS) are not completely understood. <h3>Objective</h3> To determine whether disability progression independent of relapse activity (PIRA) patients with RMS is associated accelerated tissue loss. <h3>Design, Setting, Participants</h3> In this observational, longitudinal cohort study median (IQR) follow-up 3.2 years (2.0-4.9), data were acquired from January 2012 to September 2019 a...
Growing evidence links COVID-19 with acute and long-term neurological dysfunction. However, the pathophysiological mechanisms resulting in central nervous system involvement remain unclear, posing both diagnostic therapeutic challenges. Here we show outcomes of a cross-sectional clinical study (NCT04472013) including imaging data corresponding multidimensional characterization immune mediators cerebrospinal fluid (CSF) plasma patients belonging to different Neuro-COVID severity classes. The...
The CD40-CD40L costimulatory pathway regulates adaptive and innate immune responses has been implicated in the pathogenesis of multiple sclerosis. Frexalimab is a second-generation anti-CD40L monoclonal antibody being evaluated for treatment In this phase 2, double-blind, randomized trial, we assigned, 4:4:1:1 ratio, participants with relapsing sclerosis to receive 1200 mg frexalimab administered intravenously every 4 weeks (with an 1800-mg loading dose), 300 subcutaneously 2 600-mg or...
Progression independent of relapse activity (PIRA), a recent concept to formalize disability accrual in multiple sclerosis (MS) relapses, has gained popularity as potential clinical trial outcome. We discuss its shortcomings and appraise the challenges implementing it settings, experimental trials, research. The current definition PIRA assumes that acute inflammation, which can manifest relapse, neurodegeneration, manifesting progressive accrual, be disentangled by introducing specific time...
Spinal cord segmentation is clinically relevant and notably used to compute spinal cross-sectional area (CSA) for the diagnosis monitoring of compression or neurodegenerative diseases such as multiple sclerosis. While several semi automatic methods exist, one key limitation remains: depends on MRI contrast, resulting in different CSA across contrasts. This partly due varying appearance boundary between cerebrospinal fluid that sequence acquisition parameters. contrast-sensitive adds...
To examine morphologic changes in the somatosensory cortex (SSC) of patients with migraine.Cortical thickness SSC migraine was measured vivo and compared age- sex-matched healthy subjects. The cohort composed 24 migraine, subdivided into 12 who had aura, without controls. Group individual analyses were performed shown as average maps significant cortical thickness.Migraineurs on thicker SSCs than control group. most noticed caudal SSC, where trigeminal area, including head face, is...
Background Patients suffering from migraine with aura (MWA) and without (MWoA) show abnormalities in visual motion perception during between attacks. Whether this represents the consequences of structural changes motion-processing networks migraineurs is unknown. Moreover, diagnosis relies on patient's history, finding differences brain might help to contribute basic research aimed at better understanding pathophysiology migraine. Methods Findings To investigate a common potential anatomical...
Migraine has been traditionally considered a nonprogressive, paroxysmal disorder with no brain abnormalities between attacks. We used diffusion tensor imaging to examine interictal properties of the brains migraineurs aura, without aura and matched healthy controls. Areas lower fractional anisotropy were present in along thalamocortical tract. In addition, had ventral trigeminothalamic tract, ventrolateral periaqueductal grey matter. Our results indicate presence permanent changes...
The presence of cortical lesions in multiple sclerosis patients has emerged as an important biomarker the disease. They appear earliest stages illness and have been shown to correlate with severity clinical symptoms. However, are hardly visible conventional magnetic resonance imaging (MRI) at 3T, thus their automated detection so far little explored. In this study, we propose a fully-convolutional deep learning approach, based on 3D U-Net, for segmentation white matter 3T. For purpose,...
To determine if migraine with aura is associated neuroinflammation, which has been suggested by preclinical models of cortical spreading depression (CSD) as well imaging human pain conditions.Thirteen migraineurs and 16 healthy controls received integrated PET/MRI brain scans [11C]PBR28, a radioligand that binds to the 18 kDa translocator protein, marker glial activation. Standardized uptake value ratio (SUVR) was compared between groups, regressed against clinical variables, using region...
Cortical spreading depression (CSD) underlies the neurobiology of migraine with aura (MWA). Animal studies reveal networks microvessels linking brain-meninges-bone marrow. CSD activates trigeminovascular system, evoking a meningeal inflammatory response. Accordingly, this study examines upregulation an marker in extra-axial tissues visual aura.We used simultaneously acquired 11 C-PBR28 positron emission tomography/magnetic resonance imaging data 18kDa translocator protein (an marker) MWA...
Damage to the myelin sheath and neuroaxonal unit is a cardinal feature of multiple sclerosis; however, detailed characterization interaction between axon damage in vivo remains challenging. We applied water multi-shell diffusion imaging quantify relative axons (i) among different lesion types; (ii) normal-appearing tissue; (iii) across sclerosis clinical subtypes healthy controls. also assessed relation focal myelin/axon with disability serum neurofilament light chain as global biological...
<h3>Objective</h3> To assess whether chronic white matter inflammation in patients with multiple sclerosis (MS) as detected vivo by paramagnetic rim MRI lesions (PRLs) is associated higher serum neurofilament light chain (sNfL) levels, a marker of neuroaxonal damage. <h3>Methods</h3> In 118 MS no gadolinium-enhancing or recent relapses, we analyzed 3D-submillimeter phase and sNfL levels. Histopathologic evaluation was performed 25 from 20 additional autopsy cases. <h3>Results</h3>...
The choroid plexus has been shown to play a crucial role in CNS inflammation. Previous studies found larger multiple sclerosis (MS) compared with healthy controls. However, it is not clear whether the similarly involved MS and neuromyelitis optica spectrum disorder (NMOSD). Thus, aim of this study was compare volume NMOSD.In retrospective, cross-sectional study, patients were included by convenience sampling from 4 international centers. lateral ventricles segmented fully automatically on...
Neuropathological studies have shown that multiple sclerosis (MS) lesions are heterogeneous in terms of myelin/axon damage and repair as well iron content. However, it remains a challenge to identify specific chronic lesion types, especially remyelinated lesions, vivo patients with MS.We performed 3 studies: (1) cross-sectional study prospective cohort 115 MS 76 healthy controls, who underwent T magnetic resonance imaging (MRI) for quantitative susceptibility mapping (QSM), myelin water...