A5055986727- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Fetal and Pediatric Neurological Disorders
- MRI in cancer diagnosis
- Neonatal and fetal brain pathology
- Autism Spectrum Disorder Research
- Transcranial Magnetic Stimulation Studies
- Bone and Joint Diseases
- Neural dynamics and brain function
- Alzheimer's disease research and treatments
- Prenatal Substance Exposure Effects
- Dementia and Cognitive Impairment Research
- Ubiquitin and proteasome pathways
- Congenital Heart Disease Studies
- Lysosomal Storage Disorders Research
- Intensive Care Unit Cognitive Disorders
- Energy and Environmental Systems
- Traumatic Brain Injury Research
- EEG and Brain-Computer Interfaces
- NMR spectroscopy and applications
- Diet and metabolism studies
- Machine Learning in Healthcare
- Complex Network Analysis Techniques
- Attention Deficit Hyperactivity Disorder
Chang Gung University
2020-2025
Linkou Chang Gung Memorial Hospital
2021-2024
École Polytechnique Fédérale de Lausanne
2023
Florey Institute of Neuroscience and Mental Health
2016-2021
Chang Gung Memorial Hospital
2020-2021
The University of Melbourne
2019-2021
University of Pittsburgh
2021
Neurological Surgery
2021
National Yang Ming Chiao Tung University
2007-2013
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2013
White matter bundle segmentation using diffusion MRI fiber tractography has become the method of choice to identify white pathways in vivo human brains. However, like other analyses complex data, there is considerable variability protocols and techniques. This can result different reconstructions same intended pathways, which directly affects results, quantification, interpretation. In this study, we aim evaluate quantify that arises from for segmentation. Through an open call users...
Abstract The function of the corpus callosum (CC) is to distribute perceptual, motor, cognitive, learned, and voluntary information between two hemispheres brain. Accurate parcellation CC according fiber composition connection upmost important. In this work, population‐based probabilistic topographies CC, in standard Montreal Neurological Institute (MNI) space, are estimated by incorporating anatomical cytoarchitectural with high angular resolution diffusion imaging (HARDI) tractography....
Abstract MRtrix3 is an open-source, cross-platform software package for medical image processing, analysis and visualization, with a particular emphasis on the investigation of brain using diffusion MRI. It implemented fast, modular flexible general-purpose code framework data access manipulation, enabling efficient development new applications, whilst retaining high computational performance consistent command-line interface between applications. In this article, we provide high-level...
Introduction: Neuroinflammation plays a major role in post-stroke neuronal injury. Previous studies applied 18F-THK-5351 tau PET to identify the existence of neuroinflammation after infarction. Meanwhile, microstructural degradation white matter (WM) fibers can be observed using fixel-based analysis (FBA) diffusion MRI (dMRI). We integrate and FBA-dMRI ischemic stroke patients investigate relationship between poststroke process WM fiber alterations. Methods: 33 with lacunar infarcts received...
This article describes the development and application of an integrated, generalized, efficient Monte Carlo simulation system for diffusion magnetic resonance imaging (dMRI), named Diffusion Microscopist Simulator (DMS). DMS comprises a random walk simulator MR image synthesizer. The former has capacity to perform large-scale simulations Brownian dynamics in virtual environments neural tissues at various levels complexity, latter is flexible enough synthesize dMRI datasets from variety...
High-resolution diffusion tensor imaging (DTI) can noninvasively probe the microstructure of cortical gray matter in vivo. In this study, 0.9-mm isotropic whole-brain DTI data were acquired healthy subjects with an efficient multi-band multi-shot echo-planar sequence. A column-based analysis that samples fractional anisotropy (FA) and radiality index (RI) along radially oriented columns was then performed to quantitatively analyze FA RI dependence on depth, region, curvature, thickness...
Abstract White matter bundle segmentation using diffusion MRI fiber tractography has become the method of choice to identify white pathways in vivo human brains. However, like other analyses complex data, there is considerable variability protocols and techniques. This can result different reconstructions same intended pathways, which directly affects results, quantification, interpretation. In this study, we aim evaluate quantify that arises from for segmentation. Through an open call users...
Abstract Background Subjective cognitive decline (SCD) is an early stage of dementia linked to Alzheimer's disease pathology. White matter changes were found in SCD using diffusion tensor imaging, but there are known limitations voxel-wise tensor-based methods. Fixel-based analysis (FBA) can help understand white fibers and how they relate neurodegenerative proteins multidomain behavior data individuals with SCD. Methods Healthy adults normal cognition recruited the Northeastern Taiwan...
Traumatic brain injury (TBI) is one of the leading causes death and disability in children adolescents. Young TBI patients suffer from gross motor deficits, such as postural control which can severely compromise their daily life activities. However, little attention has been devoted to uncovering underlying white matter changes response training TBI. In this study, we used longitudinal fixel-based analysis (FBA), an advanced diffusion imaging technique, investigate effect a balance program...
Changes in connectivity of white matter fibers remote to a stroke lesion, suggestive structural connectional diaschisis, may impact on clinical impairment and recovery after stroke. However, until recently, we have not had tract-specific techniques map changes tracts vivo humans enable investigation potential mechanisms such changes. Our aim was identify quantify that are affected from lesion investigate the associations between reductions impaired touch discrimination function stroke.We...
Neuroimage literature of autism spectrum disorder (ASD) has a moderate-to-high risk bias, partially because those combined with intellectual impairment (II) and/or minimally verbal (MV) status are generally ignored. We aimed to provide more comprehensive insights into white matter alterations ASD, inclusive individuals II (ASD-II-Only) or MV expression (ASD-MV).Sixty-five participants ASD (ASD-Whole; 16.6 ± 5.9 years; comprising 34 intellectually able youth, ASD-IA, and 31 impaired ASD-II,...
Following the published behavioral and cognitive results of this single-blind parallel sham-controlled randomized clinical trial, current study aimed to explore impact intermittent theta burst stimulation (iTBS), a variant excitatory transcranial magnetic stimulation, over bilateral posterior superior temporal sulci (pSTS) on white matter macro/microstructure in intellectually able children adolescents with autism. Participants were blindly received active or sham iTBS for 4 weeks (the...