A5052887497- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury Research
- Transcranial Magnetic Stimulation Studies
- Advanced MRI Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Dementia and Cognitive Impairment Research
- Fetal and Pediatric Neurological Disorders
- Neurological disorders and treatments
- Neural and Behavioral Psychology Studies
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Neonatal and fetal brain pathology
- Neuroscience and Neuropharmacology Research
- Vestibular and auditory disorders
- Epilepsy research and treatment
- Psychosomatic Disorders and Their Treatments
- Stress Responses and Cortisol
- EEG and Brain-Computer Interfaces
- Cardiac Arrest and Resuscitation
- Neurological Disease Mechanisms and Treatments
- MRI in cancer diagnosis
- Optical Imaging and Spectroscopy Techniques
- Body Image and Dysmorphia Studies
- Migraine and Headache Studies
Monash Alfred Psychiatry Research centre
2016-2025
The Alfred Hospital
2012-2023
Monash University
2014-2023
Australian National University
2006-2023
Austin Health
2023
The University of Sydney
2016-2020
The University of Melbourne
2006-2020
General Electric (Spain)
2020
The Heart Research Institute
2016-2019
Alfred Health
2019
White matter bundle segmentation using diffusion MRI fiber tractography has become the method of choice to identify white pathways in vivo human brains. However, like other analyses complex data, there is considerable variability protocols and techniques. This can result different reconstructions same intended pathways, which directly affects results, quantification, interpretation. In this study, we aim evaluate quantify that arises from for segmentation. Through an open call users...
The dorsolateral prefrontal cortex (DLPFC) has been implicated in the pathophysiology of several psychiatric illnesses including major depressive disorder and schizophrenia. In this regard, DLPFC targeted repetitive transcranial magnetic stimulation (rTMS) studies as a form treatment to those patients who are resistant medications. '5-cm method' '10-20 for positioning (TMS) coil over have scrutinised due poor targeting accuracies attributed inter-subject variability. We evaluated accuracy...
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Background. Previous research has found that depression is a major cause of memory complaints. However, there evidence complaints also weakly predict cognitive decline and dementia. The present study examined range possible determinants complaints, covering psychiatric personality factors, medical history, test performance, biological risk factors for dementia (APOE genotype, hippocampus amygdala volumes, white-matter hyperintensities). Method. A community survey was carried out with 2546...
Abstract Background An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of hippocampus on MR. The aim this study is to concurrent validity HarP toward local protocols, and its major sources variance. Methods Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T 3T following qualified based through standard web‐platform resegmented HarP. five most accurate followed segment 15 ADNI acquired three...
Individuals' cognitive abilities predict functional outcomes following traumatic brain injury (TBI). However, it is not known to what extent concurrent affect the magnitude or rate of recovery. The current study modeled progression outcome as related background, severity, and variables over first year postinjury.This comprised 111 individuals with moderate-to-severe TBI assessed on average at 3, 6, 13 months postinjury. In addition, 79 healthy controls were a single time point. Each...
The hippocampus is a key component of emotional and memory circuits broadly connected throughout the brain. We tracked whole-brain connections white matter fibres from using ultra-high angular resolution diffusion MRI in both single 1150-direction dataset large normal cohort (n = 94; 391-directions). Using connectomic approach, we identified six dominant pathways terms strength, length anatomy, characterised them by their age gender variation. strongest individual connection was to...
<h3>Background:</h3> There is evidence of structural brain alterations in major depressive disorder (MDD), but little known about how these might be affected by age at onset or genetic vulnerability. This study examines whether lifetime episodes MDD are associated with specific grey-matter volume, and those vary according to sex serotonin transporter-linked promoter region (5-HTTLPR) genotype (LL, SL SS). <h3>Methods:</h3> We used MRI acquire anatomic scans from 610 community-dwelling...
Several factors may mitigate the efficacy of repetitive transcranial magnetic stimulation (rTMS) over sham rTMS in patients with treatment-resistant depression (TRD). These include unilateral (i.e., treatment only left dorsolateral prefrontal cortex [DLPFC]), suboptimal methods targeting DLPFC and insufficient intensity (based on coil-to-cortex distance).We recruited TRD between ages 18 85 years from a university hospital, participants were randomized to receive sequential bilateral (600...
Studies of patients with major depression disorder (MDD) have revealed reduced hippocampal volumes, but findings been inconsistent due to sample and measurement differences. The current study sought measure this structure in a large MDD control subjects, using strict protocol, order elucidate morphological-specific volumetric Forty-five subjects treatment-resistant 26 controls underwent psychiatric assessments brain magnetic resonance imaging (MRI). indicate that (1) results volume,...
Background. Moderate-severe traumatic brain injury (TBI) is increasingly being understood as a progressive disorder, with growing evidence of reduced volume and white matter integrity well lesion expansion in the chronic phases injury. The scale these losses has yet to be investigated, pattern change across structures received limited attention. Objectives. To measure (1) proportion moderate-severe TBI patients atrophy from 5 20 mos post-injury, (2) relative vulnerability consistency loss...
Abstract Traumatic brain injury (TBI) in children results damage to the developing brain, particularly severely injured individuals. Little is known, however, of long‐term structural aspects following childhood TBI. This study investigated integrity 10 years post‐TBI using magnetic resonance imaging volumetrics a sample 49 participants with mild, moderate and severe TBI, evaluated against normative 20 individuals from pediatric database comparable age gender distribution. Structural was gray...
There are reports of differences in occipital lobe asymmetry within psychiatric populations when compared with healthy control subjects. Anecdotal evidence and enlarged lateral ventricles suggests that there may also be a different pattern curvature whereby one wraps around the other, termed 'occipital bending'. We investigated prevalence bending 51 patients major depressive disorder (males mean age = 41.96 ± 14.00 years, females 40.71 12.41 years) 48 age- sex-matched subjects 40.29 10.23...