A5042275901- COVID-19 epidemiological studies
- Soil Geostatistics and Mapping
- Spatial and Panel Data Analysis
- Global Cancer Incidence and Screening
- SARS-CoV-2 and COVID-19 Research
- Advanced Wireless Network Optimization
- Climate Change and Health Impacts
- COVID-19 Clinical Research Studies
- Network Traffic and Congestion Control
- Statistical Methods and Bayesian Inference
- Air Quality and Health Impacts
- Bayesian Methods and Mixture Models
- Data-Driven Disease Surveillance
- Advanced MIMO Systems Optimization
- Peer-to-Peer Network Technologies
- Advanced Queuing Theory Analysis
- Advanced Data Storage Technologies
- COVID-19 and healthcare impacts
- Statistical Methods and Inference
- Colorectal Cancer Screening and Detection
- Caching and Content Delivery
- Salmonella and Campylobacter epidemiology
- Systemic Lupus Erythematosus Research
- SARS-CoV-2 detection and testing
- Vaccine Coverage and Hesitancy
University of Toronto
2016-2025
St. Michael's Hospital
2017-2025
Centre for Global Health Research
2017-2025
St Michaels Hospital
2020-2024
Stantec (Canada)
2024
Orange (France)
2005-2023
Saint Leo University
2023
Saskatchewan Health
2023
McGill University Health Centre
2023
University of Saskatchewan
2023
The World Health Organization call to halve global snakebite deaths by 2030 will require substantial progress in India. We analyzed 2833 from 611,483 verbal autopsies the nationally representative Indian Million Death Study 2001 2014, and conducted a systematic literature review 2000 2019 covering 87,590 snakebites. estimate that India had 1.2 million (average 58,000/year) 2019. Nearly half occurred at ages 30–69 years over quarter children < 15 years. Most home rural areas. About 70%...
India’s national COVID death totals remain undetermined. Using an independent nationally representative survey of 0.14 million (M) adults, we compared mortality during the 2020 and 2021 viral waves to expected all-cause mortality. constituted 29% (95% confidence interval, 28 31%) deaths from June July 2021, corresponding 3.2 M (3.1 3.4) deaths, which 2.7 (2.6 2.9) occurred in April (when doubled mortality). A subsurvey 57,000 adults showed similar temporal increases mortality, with non-COVID...
BACKGROUND: Smoking cessation reduces mortality and morbidity. However, the extent rapidity at which contemporary death rates from smoking-related illnesses remain uncertain. METHODS: We pooled current or former versus never cigarette smoker hazard ratios four national cohorts with linkage to registries in United States, Kingdom, Norway, Canada among adults 20 79 years of age 1974 2018. calculated excess risk differences survival, comparing smokers age-specific fewer than 3, 3 9, 10 more...
Abstract A mutant in the maize (Zea mays) Glycolate Oxidase1 (GO1) gene was characterized to investigate role of photorespiration C4 photosynthesis. An Activator-induced allele GO1 conditioned a seedling lethal phenotype when homozygous and had 5% 10% wild-type GO activity. Growth seedlings high CO2 (1%–5%) sufficient rescue phenotype. Upon transfer normal air, go1 became necrotic within 7 d plants died 15 d. Providing [1-14C]glycolate leaf tissue mutants darkness confirmed that substrate is...
Understanding how plant species coexist in tropical rainforests is one of the biggest challenges community ecology. One prominent hypothesis suggests that rare are at an advantage because trees have lower survival areas high conspecific density due to increased attack by natural enemies, a process known as negative dependence (NDD). A consensus emerging NDD important for plant-species coexistence forests. Most evidence comes from short-term studies, but testing prediction decreases spatial...
1 Interspecific relationships between fundamental demographic rates, often called trade-offs, emerge from constraints within individuals related to morphology, physiology and resource allocation. Plant species that grow fast in high light usually have mortality shade, this well-established relationship part defines a species' successional niche. More generally, represents trade-off ability quickly exploit abundant resources vs. avoiding when are less plentiful, but few studies described with...
Proprotein convertase subtilisin kexin type 9 (PCSK9) promotes the degradation of low-density lipoprotein (LDL) receptor (LDLR), and its deficiency in humans results low plasma LDL cholesterol protection against coronary heart disease. Recent evidence indicates that PCSK9 also modulates metabolism triglyceride-rich apolipoprotein B (apoB) lipoproteins, another important disease risk factor. Here, we studied effects physiological levels on intestinal apoB production elucidated for first time...
Several factors may mitigate the efficacy of repetitive transcranial magnetic stimulation (rTMS) over sham rTMS in patients with treatment-resistant depression (TRD). These include unilateral (i.e., treatment only left dorsolateral prefrontal cortex [DLPFC]), suboptimal methods targeting DLPFC and insufficient intensity (based on coil-to-cortex distance).We recruited TRD between ages 18 85 years from a university hospital, participants were randomized to receive sequential bilateral (600...
Low latency targets for ultra-reliable low communications (URLLC) may be conflicting with their stringent reliability requirements due to the need re-transmissions. We explore, in this paper, different resource allocation schemes transmissions and re-transmissions depending on of underlying service traffic characteristics, focusing Industrial Internet Things. We, namely, consider individual reservation versus a pool contention-based reserved resources. provide novel initial derive...
<h3>Background:</h3> During the first year of COVID-19 pandemic, proportion reported cases among Canadians was under 6%. Although high vaccine coverage achieved in Canada by fall 2021, Omicron variant caused unprecedented numbers infections, overwhelming testing capacity and making it difficult to quantify trajectory population immunity. <h3>Methods:</h3> Using a time-series approach data from more than 900 000 samples collected 7 research studies collaborating with Immunity Task Force...
Summary Recent progress in determining the population structure of Campylobacter jejuni , and discerning associations between genotypes specific niches, has emphasized shortfall our understanding ecology epidemiology this bacterium. We examined natural C. community associated with cattle farmland UK by structured spatiotemporal sampling habitats, including livestock wild animal faeces, environmental water soil, over a 10‐week period within 100 km 2 area. A total 172 isolates were...
Summary Statistical space–time modelling has traditionally been concerned with separable covariance functions, meaning that the function is a product of purely temporal and spatial function. We draw attention to physical dispersion model which could phenomena such as spread an air pollutant. show this non-separable The well suited wide range realistic problems will be poorly fitted by models. operates successively in time: field at time t +1 obtained ‘blurring’ adding random field. first...
This paper briefly describes geostatistical models for Gaussian and non-Gaussian data demonstrates the geostatsp dieasemapping packages performing inference using these models. Making use of R's spatial types, raster objects in particular, makes analyses simple convenient. Examples real are shown data, binomially distributed a logGaussian Cox process, an area-level model case counts.
ABSTRACT Humans are exposed to Campylobacter spp. in a range of sources via both food and environmental pathways. For this study, we explored the frequency distribution thermophilic 10- by 10-km square rural area Cheshire, United Kingdom. The contains approximately 70, mainly dairy, farms is used extensively for outdoor recreational activities. were isolated from samples use systematic sampling grid. Livestock (mainly cattle) wildlife feces water soil cultured, isolates presumptively...
Internet measurements show that a small number of large TCP flows are responsible for the largest amount data transferred, whereas most sessions made up few packets. Several authors have invoked this property to suggest use scheduling algorithms, which favor short jobs, such as LAS (least attained service), differentiate between and long flows. We propose packet level stateless, threshold based mechanism flows, RuN2C. describe an implementation mechanism, has advantage being compatible...
Methods for the statistical analysis of stationary spatial point process data are now well established, methods nonstationary processes less so. One many sources is a case-control study in environmental epidemiology. In that context, consist realization each two representing locations, within specified geographical region, individual cases disease and controls drawn at random from population risk. this article, we extend work by Baddeley, Møller, Waagepetersen (2000, Statistica...
BackgroundThere is controversy about whether adding clinical breast examination (CBE) to mammography improves the accuracy of screening. We compared screening among centers that offered CBE in addition with only mammography.
To evaluate the performance of digital direct radiography (DR) and computed (CR) compared with that screen-film mammography (SFM) in large concurrent cohorts.This study was approved by University Toronto Research Ethics Board did not require informed consent. Concurrent cohorts women aged 50-74 years screened DR (n = 220 520), CR 64 210), or SFM 403 688) between 2008 2009 were identified followed for 12 months. Performance cohorts, as referent cohort. Associations examined using mixed-effect...
Objective Cutaneous neonatal lupus (cNL) occurs in possibly 5%–16% of anti-Ro±anti-La antibody–exposed infants. Data suggest utero exposure to hydroxychloroquine (HCQ) may prevent cardiac NL. The aim was assess whether HCQ decreases the risk cNL and/or delays onset. Methods A multicentre case–control study performed with 122 cases and 434 controls born women a rheumatological disease who had documentation maternal antibodies at pregnancy confirmation medication use child’s outcome. secondary...
Article Abstract Objective: The purpose of this study was to evaluate the effects repetitive transcranial magnetic stimulation (rTMS) on suicidal ideation in patients with treatment-resistant major depression (TRD) (patients who failed clinically respond at least 2 medication trials). Methods: We pooled data from published prospective randomized controlled trials rTMS applied dorsolateral prefrontal cortex TRD. compared effect bilateral, left unilateral, and sham as measured by suicide item...
Recent studies have suggested that prenatal exposure to HCQ reduces the risk of cardiac neonatal lupus. The aim this study is assess if maternal intake antimalarials (AMs) throughout pregnancy lowered and non-cardiac lupus.Consecutive children seen between 1 January 1984 October 2013 born women with a CTD positive anti-Ro and/or anti-La antibodies were eligible for single-centre retrospective cohort study. A total 315 individuals screened 268 participants included. Exposure AMs was defined...